Blood-Spinal Cord and Brain Barriers in Health and Disease
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Table of contents
- Cover
- Contentsv
- Contributorsvii
- Forewordix
- Introductionxi
- Prefacexiii
- Acknowledgmentsxvi
- Section I: Basic Aspects: Structure and Functions of Cerebrovascular Barriers1
- Chapter 1. Proteins of the Tight Junction in the Blood–Brain Barrier1
- Chapter 2. Direct Demonstration of Association of the Blood–Brain Barrier Proteins ZO-1 and Occlud11
- Chapter 3. Investigation of Molecular Mechanisms Involved in T Lymphocyte Recruitment across the Blo19
- Section II: Technical and Functional Aspects: Cerebrovascular Barriers In Vitro33
- Chapter 4. Transport and Permeability Characteristics of the Blood–Cerebrospinal Fluid Barrier in33
- Chapter 5. Brain Microvessel Endothelial Cell Cultures as in Vitro Models to Study the Blood–Brain47
- Section III: Physiological Aspects: Transport Mechanisms Across Cerebrovascular Barriers57
- Chapter 6. Brain Influx of Endogenous Peptides Affecting Food Intake57
- Chapter 7. Implications of P-glycoprotein for the Transport and Distribution of Drugs into the Brain63
- Chapter 8. Role of the Blood–Brain Barrier in Communication between the Central Nervous System and73
- Chapter 9. Efflux Mechanisms in the Central Nervous System: A Powerful Influence on Drug Distributio83
- Chapter 10. Mechanisms of Antisense Transport across the Blood–Brain Barrier99
- Chapter 11. Peptides and the Blood–Brain Barrier: Enhancing Peptide Bioavailability to the Brain107
- Section IV: Pharmacological Aspects: Neurochemical Mediators of the Cerebrovascular Barriers117
- Chapter 12. Influence of Serotonin on the Blood–Brain and the Blood–Spinal Cord Barriers117
- Chapter 13. Histamine Influences the Blood–Spinal Cord and Brain Barriers Following Injuries to th159
- Chapter 14. Role of Nitric Oxide on the Blood–Brain and Spinal Cord Barriers191
- Section V: Neuropsychological Aspects: Cerebrovascular Barriers in Stressful Situations231
- Chapter 15. Blood–Brain and Spinal Cord Barriers in Stress231
- Chapter 16. Blood–Central Nervous System Barriers in Morphine Dependence and Withdrawal299
- Chapter 17. The Heat Shock Proteins and Hemeoxygenase Response in Central Nervous System Injuries329
- Section VI: Neurological Aspects: Alterations of Cerebrovascular Barriers in Disease Conditions361
- Chapter 18. Volume Transmission-Mediated Protective Impact of Choroid Plexus–Cerebrospinal Fluid G361
- Chapter 19. Blood–Brain Barrier Changes in Global and Focal Cerebral Ischemia385
- Chapter 20. Transport of Cytokines and Neurotrophins across the Blood–Brain Barrier and Their Regu395
- Chapter 21. Mononuclear Phagocytes at the Blood–Brain Barrier in Multiple Sclerosis409
- Chapter 22. The Blood–Brain Barrier after Traumatic Injury: Vascular and Parenchymal Interactions419
- Chapter 23. Pathophysiology of the Blood–Spinal Cord Barrier in Traumatic Injury437
- Chapter 24. Growth Hormone Permeability Across the Blood–Spinal Cord and Brain Barriers and Its Th519
- Chapter 25. Involvement and Consequences of Blood Brain Barrier Permeability After Minimal Injury in533
- Section VII: Clinical Aspects: Cerebrovascular Barriers in Clinical Conditions547
- Chapter 26. Neural Immunity and Human Immunodeficiency Virus-1-Associated Dementia547
- Chapter 27. The Blood–Brain Barrier in the Human Glioma561
- Index577
Recent research into the anatomy and pathophysiology of the blood-brain and blood-spinal cord barriers suggests that a breakdown in these barriers can result in several diseases affecting the central nervous system (CNS). This book presents new findings in the area of blood-brain barrier research that suggest barriers play important roles in health and disease conditions. It also discusses the development of new drugs that can modulate the barrier function in the CNS and may provide new approaches to treating neurological diseases such as Alzheimer's disease and other motor neuron diseases, as well as spinal cord trauma.
Key Features
* Presents the recent progress made in the research on the blood-brain and spinal cord barrier
* Contains numerous illustrations of light and electron micrographs
* Includes Foreword written by two eminent researchers in the field, Milton Brightman and Jorge Cervos-Navarro
Key Features
* Presents the recent progress made in the research on the blood-brain and spinal cord barrier
* Contains numerous illustrations of light and electron micrographs
* Includes Foreword written by two eminent researchers in the field, Milton Brightman and Jorge Cervos-Navarro