Elsevier S & T

Blood Substitutes, Present and Future Perspectives

Tsuchida, E.

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Table of contents
  • Cover
  • Table of Contentsvii
  • Chapter 1. Perspectives of Blood Substitutes1
  • Chapter 2. The Role of Blood Substitutes in Emerging Healthcare Systems15
  • Chapter 3. Red Cell Substitutes: Evolution of Approaches for Demonstrating Efficacy33
  • Chapter 4. The Clinical Utility of Human Polymerized Hemoglobins as a Blood Substitute Following Acu41
  • Chapter 5. Recent Progress in the Development of Recombinant Human Hemoglobin (rHbl.1) as an Oxygen55
  • Chapter 6. Overview of the Effects of Diaspirin Crosslinked Hemoglobin (DCLHb) on Oxygenation, Perfu75
  • Chapter 7. Update on Perfluorocarbon-Based Oxygen Delivery Systems91
  • Chapter 8. Red Cell Substitutes: Past Problems, Current Dilemmas103
  • Chapter 9. Round Table Discussion: "The Target and Assessment of Clinical Tests"111
  • Chapter 10. Biophysical Criteria for Microcirculatory Efficacy of Blood Substitutes125
  • Chapter 11. Experimental and Mathematical Simulation of Oxygen Transport by Hemoglobin-based Blood S135
  • Chapter 12. Tissue Oxygen Delivery and Tissue Distribution of Liposome Encapsulated Hemoglobin147
  • Chapter 13. Polymeric Biodegradable Hemoglobin Nanocapsule as a New Red Blood Cell Substitute161
  • Chapter 14. Evaluation of the Oxygen Transporting Capability of Hemoglobin Vesicles171
  • Chapter 15. Microvascular Responses to Hemodilution with Hb-Vesicles: Importance of Resistance Arter185
  • Chapter 16. Hemoglobin-based Blood Substitutes and Mechanisms of Toxicity201
  • Chapter 17. in vivo Oxygenation of Deoxy-Hemolink’ Following Exchange Transfusions of 50% or 90% t211
  • Chapter 18. Safety and Efficacy of Hemoglobin Modified by Cross-linking or Polymerization225
  • Chapter 19. The Heme Oxygenase System In Liver Microcirculation: A Key Mechanism for Hemoglobin Degr241
  • Chapter 20. Vascular Activities of Hemoglobin-Based Oxygen Carriers251
  • Chapter 21. Zero-link Polymerization: a New Class of Polymeric Hemoglobins265
  • Chapter 22. Recombinant Hemoglobins with Low Oxygen Affinity and High Cooperativity281
  • Chapter 23. Properties of Poly(ethylene glycol)-conjugated Red Blood Cells297
  • Chapter 24. Oxygen-Transport Albumin: A New Hemoprotein Incorporating Lipidheme as a Red Cell Substi315
  • Chapter 25. Fluorocarbon Emulsions as Blood Substitutes327
  • Chapter 26. Heparin-like New Molecules with Blood339
  • Chapter 27. Recent Developments and Future Perspectives for Preserved Platelets and Platelet Substit359
  • Chapter 28. Development and Clinical Implications of Platelet Substitutes373
  • Chapter 29. Impact on the Appearance of Blood Substitutes Replacing Blood in Transfusion Medicine383
Book details
  • Vendor Elsevier S & T
  • SKU 9780444205247
  • ISBN-13 9780080528212
  • Author Tsuchida, E.
  • Category Medical
  • Subject Pharmacology

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Description eBook delivery & access Reviews
This book contains the selected papers presented at the seventh International Symposium on Blood Substitutes (7th ISBS) held at the International Conference Center of Waseda University in Tokyo on 7-10 September 1997. In keeping with the scientific design of the 7th ISBS Symposium, chapters have been carefully selected and organized to showcase the advancements in recent research. This book includes up-to-date clinical results of leading companies which are manufacturing hemoglobin-based or fluorocarbon-based blood substitutes, and covers issues of hemoglobin toxicity and side effects such as vasoconstriction in more detail using carefully designed in vivo and ex vivo techniques. This book is also a collection of various new types of red cell substitutes such as recombinant Hbs, recombinant albumine-lipidheme complex, modified red blood cells, and perfluorochemicals using material science and molecular engineering.