Cell Surface Proteases
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Table of contents
- Copyright Pageiv
- Contentsv
- Dedicationxi
- Contributorsxiii
- Prefacexv
- Forewordxvii
- Introductionxix
- Chapter 1. Membrane Type-Matrix Metalloproteinases (MT-MMP)1
- I. Introduction2
- II. Secreted MMPs3
- III. Membrane Type-Matrix Metalloproteinases (MT-MMPs)7
- IV. Summary and Concluding Remarks52
- References53
- Chapter 2. Surface Association of Secreted Matrix Metalloproteinases75
- I. Introduction75
- II. Surface Binding of MMP-978
- III. Surface Binding of the Soluble Interstitial Collagenases (MMP-1 and MMP-13)84
- IV. Surface Binding of MMP-789
- V. Surface Binding of MMP-1991
- VI. Concluding Remarks. Surface Binding: A Balance between Positive and Negative Effects on Pericell92
- References94
- Chapter 3. Biochemical Properties and Functions of Membrane-Anchored Metalloprotease-Disintegrin Pro101
- I. Introduction101
- II. Structural Chemistry and Biochemistry103
- III. Expression in Different Tissues and Regulation of Gene Expression109
- IV. Interactions of ADAMs with Other Extracellular and Intracellular Proteins110
- V. Roles in Embryogenesis and Development113
- VI. Roles in Disease114
- VII. Concluding Comments and Future Directions115
- References116
- Chapter 4. Shedding of Plasma Membrane Proteins125
- I. Introduction125
- II. Functional Consequences of Ectodomain Shedding126
- III. Proteases Involved in Ectodomain Shedding131
- IV. How are Substrates Selected?134
- V. Regulation136
- References138
- Chapter 5. Expression of Meprins in Health and Disease145
- I. Introduction145
- II. Expression and Proposed Functions of Astacin Family Members150
- III. Meprin Expression in Cancer155
- IV. Meprins in Inflammatory Diseases158
- V. Summary, Concluding Remarks, Future Directions161
- References161
- Chapter 6. Type II Transmembrane Serine Proteases167
- I. Introduction168
- II. General Features of Type II Transmembrane Serine Proteases169
- III. Corin173
- IV. Enteropeptidase178
- V. Hepsin181
- VI. Matriptase185
- VII. Transmembrane Protease, Serine 2 (TMPRSS2)190
- VIII. Transmembrane Protease, Serine 3 (TMPRSS3)192
- IX. Transmembrane Protease, Serine 4 (TMPRSS4)193
- X. Other Transmembrane Serine Proteases194
- XI. Perspective196
- References197
- Chapter 7. DPPIV, Seprase, and Related Serine Peptidases in Multiple Cellular Functions207
- I. Introduction207
- II. Structural Chemistry and Biochemistry of SIMP210
- III. Biologic and Pathologic Roles219
- IV. Conclusions and Future Directions226
- References227
- Chapter 8. The Secretases of Alzheimer’s Disease233
- I. The Amyloid Hypothesis of Alzheimer’s Disease233
- II. β-Secretase236
- III. γ -Secretase240
- IV. α-Secretase249
- V. Concluding Remarks251
- References252
- Chapter 9. Plasminogen Activation at the Cell Surface263
- I. Introduction263
- II. Structural Chemistry/Biochemistry266
- III. Cellular Binding Sites and the Regulation of the Plasminogen Activation System279
- IV. uPAR as a Regulator of Cell Migration286
- V. Biological and Pathological Roles291
- VI. Concluding Remarks297
- References300
- Chapter 10. Cell-Surface Cathepsin B: Understanding Its Functional Significance313
- I. Introduction313
- II. Cathepsin B Expression and Cancer315
- III. Compartmentalization of Cathepsin B318
- IV. Association of Cathepsin B with the Cell Surface323
- V. Functional Significance of Cell-Surface Cathepsin B328
- VI. Conclusions333
- References333
- Chapter 11. Protease-Activated Receptors343
- I. Introduction and General Overview343
- II. Structural Biochemistry and Classification345
- III. PAR Molecular and Developmental Genetics353
- IV. PARs In Disease and Pathological Processes357
- V. Development and Application of PAR Inhibitors361
- VI. Concluding Remarks362
- References363
- Chapter 12. Emmprin (CD147), a Cell Surface Regulator of Matrix Metalloproteinase Production and Fun371
- I. Introduction371
- II. Regulation of MMP Production by Emmprin372
- III. Emmprin Binding Partners376
- IV. Role of Emmprin in Tumor Progression378
- V. Diverse Cellular Functions of Emmprin and Its Homologs in Physiology and Pathology381
- VI. Concluding Remarks383
- References383
- Chapter 13. The Evolving Roles of Cell Surface Proteases in Health and Disease: Implications for Dev391
- I. Introduction391
- II. Development391
- III. Normal Homeostasis and Adaptive Responses396
- IV. Inflammation and Repair399
- V. Neoplastic Processes403
- VI. Conclusions405
- References405
- Chapter 14. Shed Membrane Vesicles and Clustering of Membrane-Bound Proteolytic Enzymes411
- I. Introduction411
- II. Membrane Vesicle Release417
- III. Role of Shed Vesicles in Cell–Cell Interactions420
- IV. Role of Shed Vesicles in Cell Matrix Interactions422
- V. Fate of Shed Membrane Vesicles426
- VI. Concluding Remarks and Perspective427
- References427
- Index433
- Contents of Previous Volumes447
Cell Surface Proteases provides a comprehensive overview of these important enzymes that catalyze the hydrolysis of a protein as it degrades to a simpler substance. In the 1990s, an explosion of new discoveries shed light on the role of cell surface proteases and extended it beyond degradation of extracellular matrix components to include its influence on growth factors, cell signaling, and other cellular events. This volume unites the scientific literature from across disciplines and teases out unified themes of interactions between cell surface proteases and interconnecting cell surface-related systems -- including integrins and other adhesion molecules. Scientists and students involved in developmental biology, cell biology and disease processes will find this an indispensable resource.
* Provides an overview of the entire field of cell surface proteases in a single volume
* Presents major issues and astonishing discoveries at the forefront of modern developmental biology and developmental medicine
* A thematic volume in the longest-running forum for contemporary issues in developmental biology with over 30 years of coverage
* Provides an overview of the entire field of cell surface proteases in a single volume
* Presents major issues and astonishing discoveries at the forefront of modern developmental biology and developmental medicine
* A thematic volume in the longest-running forum for contemporary issues in developmental biology with over 30 years of coverage