Cell Surface Receptors
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Table of contents
- Contentsv
- Prefacexi
- Chapter 1. Structure and Function of the Epidermal Growth Factor (EGF/ErbB) Family of Receptors1
- I. Introduction1
- II. The EGF and EGFR Families3
- III. Association of ErbB Receptors with Human Disease6
- IV. Structure of Individual ErbB Receptor Domains7
- V. Structure of Entire ErbB Receptor Ectodomains9
- VI. HER215
- VII. Therapeutic Anti-HER2 Antibodies18
- VIII. Remaining Questions20
- References22
- Chapter 2. The Three-Dimensional Structure of Integrins and Their Ligands, and Conformational Regula29
- I. Introduction30
- II. Conformational Regulation of Integrin Structure and Function31
- III. Integrin/Ligand Interactions47
- References57
- Chapter 3. Structures of Axon Guidance Molecules and Their Neuronal Receptors65
- I. Introduction65
- II. Eph Receptors and Ephrins66
- III. Semaphorins, Neuropilins, and Plexins82
- IV. Myelin-Associated Inhibitors of Axonal Regeneration90
- V. Conclusion and Perspectives98
- References99
- Chapter 4. Shared Cytokine Signaling Receptors: Structural Insights from the gp130 System107
- I. Cross-Reactive Signaling Receptors in Biology108
- II. Cytokines and Receptors109
- III. The Growth Hormone Paradigm: Generalities and Limitations110
- IV. Shared Signaling Receptors for Hematopoietic Cytokines113
- V. gp130 Family of Cytokines and Receptors118
- VI. A Structural Basis of gp130 Cross Reactivity: Site II128
- VII. Thermodynamic Basis for a Universal Binding Solution130
- VIII. Cross-Reactivity of the gp130 IGD with Cytokine Site III132
- IX. Predicting the Higher-Order Assemblies of the Asymmetric Complexes (gp130/LIFR)135
- X. Translating Ligand Recognition into Signaling137
- References139
- Chapter 5. The Structural Basis for Biological Signaling, Regulation, and Specificity in the Growth147
- I. Structural Basis for Receptor Homodimerization149
- II. Hormone Receptor Binding Sites152
- III. Hormone-Receptor Binding Energetics: The Binding ‘‘Hot-Spot’’ Concept155
- IV. Stereoselectivity of the Prolactin Receptor (hPRLR)158
- V. Comparison of the hGH Site1 and Site2 Binding Energy Epitopes in the hGH-hGHR Ternary Complex159
- VI. Protein Engineering to Create New Properties160
- VII. Allosteric Effects, A Big Surprise161
- VIII. Biological Implications of Transient Receptor Dimerization164
- IX. Mechanism of ECD2 Binding, the Regulation Step in Biological Signaling165
- X. Future Directions165
- References166
- Chapter 6. Structural Analysis of IL-10 and Type I Interferon Family Members and Their Complexes wit171
- I. Introduction171
- II. Structures of the HCIIs177
- III. Structures of the Class 2 Homology Region (C2HR)195
- IV. Structure of the High-Affinity HCII/C2HR Interfaces204
- V. Concluding Remarks215
- References215
- Chapter 7. Assembly of Post-Receptor Singnaling Complexes for the Tumor Necrosis Factor Receptor Sup225
- I. Introduction226
- II. Domain and Oligomeric Structures of TRAFs234
- III. TRAF2-Receptor Interactions: Establishment of the Paradigm241
- IV. TRAF3-Receptor Interactions: Similarities and Differences with TRAF2248
- V. TRAF6-Receptor Interactions: Distinct Specificity251
- VI. Thermodynamics of TRAF-Receptor Interactions254
- VII. TRAF2-TRADD Interaction: A Novel Mode of TRAF Signaling256
- VIII. TRAF Signaling Inhibitors261
- IX. DD and DD-DD Interactions262
- X. Conclusion: Emerging Principles of Post-Receptor Signal Transduction265
- References271
- Chapter 8. NKG2D and Related Immunoreceptors281
- I. T Cell Receptors and MHC Class I Proteins: Paradigms of Immunological Recognition282
- II. NK Cells and Receptors284
- III. NKG2x NK Cell Receptors288
- IV. HuNKG2D Ligands: MIC-A/B291
- V. HuNKG2D Ligands: ULBPs293
- VI. MuNKG2D Ligands: RAE-1s, H60, and MULT1294
- VII. NKG2D–Ligand Complexation295
- VIII. NKG2D–Ligand Recognition Degeneracy: ‘‘Rigid Adaptation’’ Rather Than ‘‘Induced-299
- IX. NKG2D: Open Questions303
- X. NKG2D: Implications for NKG2x–CD94 Recognition304
- XI. MIC and yd TCRs306
- References307
- Chapter 9. Ionotropic Glutamate Receptor Recognition and Activation313
- I. Introduction314
- II. Beginnings of Structure: Cloning, Mutagenesis, Transmembrane Topology, and Homology Models315
- III. The Amino Terminal Domain (ATD)318
- IV. Structure and Dynamics of the Glutamate-Binding Domain319
- V. Structure of the Ion Channel329
- VI. The C-Terminal Domain331
- VII. Relating Structure, Function, and Dynamics: Channel Gating and Desensitization332
- VIII. Evolution of Glutamate Receptors339
- IX. Summary341
- References341
- Chapter 10. Chemokine-Receptor Interactions: GPCRs, Glycosaminoglycans and Viral Chemokine Binding P351
- I. Introduction352
- II. The Chemokine Superfamily354
- III. Interaction of Chemokines and Glycosaminoglycans367
- IV. Viral Chemokines and Receptors, Chemokine Mimics, and Chemokine Binding Proteins373
- V. Chemokines and Disease378
- References381
- Chapter 11. Chemotaxis Receptors and Signaling393
- I. Introduction to Chemotaxis394
- II. Signal Transduction Events396
- III. G Protein-Coupled Receptors400
- IV. Conserved Elements of GPCR Structure402
- V. Rhodopsin Structure407
- VI. Proposed GPCR Activation Mechanisms408
- VII. Activation Mechanisms of Specific Chemotaxis GPCRs413
- VIII. Receptor Oligomerization426
- IX. Conclusions429
- References432
- Author Index445
- Subject Index487
- Color Plate SectionColor Plate1
Cell Surface Receptors contains an extensive discussion of cell surface receptors in 11 chapters by experts in their field. As cell surface receptors are involved in almost every aspect of signaling throughout the body, the topic has been of high interest in the community in recent years.
Selected Contents:
-Structures of Axon Guidance Molecules and Their Neuronal Receptors
-Shared Cytokine Signaling Receptor
-NKG2D and Related Immunoreceptors
-Inonotropic Glutamat Receptor Recognition and Activation
-Chemotaxis Receptors and Signaling
Selected Contents:
-Structures of Axon Guidance Molecules and Their Neuronal Receptors
-Shared Cytokine Signaling Receptor
-NKG2D and Related Immunoreceptors
-Inonotropic Glutamat Receptor Recognition and Activation
-Chemotaxis Receptors and Signaling