Elsevier S & T

Cofactor Biosynthesis: A Mechanistic Perspective: A Mechanistic Perspective

Litwack, Gerald

In stock
No reviews
79.500 KD inc. VAT
License
Table of contents
  • Cover
  • Contentsvii
  • Prefacexi
  • Chapter 1. Biosynthesis of Riboflavin1
  • I. Introduction2
  • II. An Overview of the Riboflavin Biosynthetic Pathway3
  • III. Riboflavin Is Formed from a Purine Precursor via Diaminopyrimidine Intermediates8
  • IV. GTP Cyclohydrolase II9
  • V. Reductase and Deaminase11
  • VI. An Elusive Phosphatase12
  • VII. 3,4-Dihydroxy-2-butanone 4-Phosphate Synthase12
  • VIII. Lumazine Synthase16
  • IX. Riboflavin Synthase20
  • X. Riboflavin Synthase Paralogs in Bioluminescence23
  • XI. Riboflavin Synthase of Archaebacteria24
  • XII. The Lumazine Synthase/Riboflavin Synthase Complex of Bacillaceae25
  • XIII. Flavokinase and FAD Synthetase25
  • XIV. Riboflavin Production by Fermentation26
  • XV. Inhibitors of Riboflavin Biosynthesis27
  • XVI. Biosynthesis of Riboflavin in Plants29
  • XVII. Regulation of Riboflavin Biosynthesis in Bacillus subtilis29
  • XVIII. Biosynthesis of 5-Deaza-7,8-didemethyl-8-hydroxyriboflavin29
  • XIX. Biosynthesis of Molybdopterin31
  • XX. Conclusion33
  • References37
  • Chapter 2. Biosynthesis of Biotin and Lipoic Acid51
  • I. Biosynthesis of Biotin52
  • II. Biosynthesis of Lipoic Acid85
  • III. Conclusion90
  • References91
  • Chapter 3. The Biosynthesis of Nicotinamide Adenine Dinucleotides in Bacteria103
  • I. Introduction104
  • II. The NAD(P) Biosynthetic Pathway in Bacteria104
  • III. The Biosynthetic Enzymes104
  • IV. The Enzymes of NAD(P) Recycling and Salvage112
  • V. Regulation of NAD(P) Biosynthesis114
  • VI. NAD(P) Biosynthesis in Eukaryotes114
  • VII. NAD(P) in Human Nutrition115
  • VIII. Summary and Conclusions116
  • References116
  • Chapter 4. Biosynthesis of Vitamin B6 and Structurally Related Derivatives121
  • I. Introduction121
  • II. Biosynthesis of Vitamin B6 in Escherichia coli123
  • III. Biosynthesis of Ginkgotoxin in Ginkgo biloba146
  • IV. Conclusions149
  • References149
  • Chapter 5. The Biosynthesis of Coenzyme A in Bacteria157
  • I. Introduction158
  • II. The Coenzyme A Biosynthetic Pathway in Bacteria158
  • III. Regulation of Coenzyme A Biosynthesis in Escherichia coli166
  • IV. Coenzyme A Biosynthesis in Saccharomyces cerevisiae166
  • V. Coenzyme A in Human Nutrition166
  • VI. Summary and Conclusions167
  • References168
  • Chapter 6. Biosynthesis of Menaquinone (Vitamin K2) and Ubiquinone (Coenzyme Q): A Perspective on En173
  • I. Introduction174
  • II. Menaquinone Biosynthesis177
  • III. Ubiquinone Biosynthesis191
  • IV. Biosynthesis of the Polyprenyl Side Chain199
  • V. Comparison of Coenzyme Q Biosynthesis in Yeast and Escherichia coli205
  • VI. Conclusions208
  • References210
  • Chapter 7. Mechanisms of Biosynthesis of Protein-Derived Redox Cofactors219
  • I. Introduction219
  • II. Biological Significance221
  • III. Discoveries of Protein-Derived Redox Cofactors222
  • IV. Biogenesis of Trihydroxyphenylalanine Quinone223
  • V. Biogenesis of Tryptophan Tryptophylquinone228
  • VI. Biogenesis of Lysine Tyrosyl Quinone231
  • VII. Biogenesis of the Cofactor in Galactose Oxidase231
  • VIII. General Mechanistic Considerations234
  • IX. Conclusion236
  • References236
  • Chapter 8. L-Ascorbic Acid Biosynthesis241
  • I. Introduction242
  • II. The Biosynthetic Pathway of Ascorbate in Mammals244
  • III. The Biosynthetic Pathway of Ascorbate in Higher Plants252
  • IV. D-Erythroascorbate Synthesis in Yeast258
  • V. Evolution of Ascorbate Biosynthesis259
  • VI. Conclusions260
  • References261
  • Chapter 9. Multiple Biosynthetic Pathways for Vitamin B12: Variations on a Central Theme267
  • I. Introduction267
  • II. The Genes and Enzymes Required for the Biosynthesis of Cobalamin from Aminolevulinic Acid269
  • III. Are There Other Variations in the Route to Vitamin B12?291
  • IV. Conclusions293
  • References293
  • Chapter 10. Biosynthesis of the Methanogenic Cofactors299
  • I. Introduction299
  • II. Biosynthesis of Methanopterin300
  • III. Biosynthesis of Coenzyme B311
  • IV. Biosynthesis of Methanofuran315
  • V. Biosynthesis of Coenzyme F420324
  • VI. Biosynthesis of Coenzyme M330
  • References330
  • Appendixes339
  • A.1 The Biosynthesis of Thiamin Pyrophosphate in Escherichia coli340
  • A.2 The Biosynthesis of Tocopherol (Vitamin E)343
  • A.3 The Biosynthesis of Retinal345
  • A.4 The Biosynthesis of Calcitriol (Dihydroxy Vitamin D3)346
  • A.5 The Biosynthesis of Pyrroloquinoline Quinone348
  • A.6 The Biosynthesis of Folate349
  • A.7 The Biosynthesis of Molybdopterin Guanine Dinucleotide352
  • Index355
Book details
  • Vendor Elsevier S & T
  • SKU 9780127098616
  • ISBN-13 9780080544533
  • Author Litwack, Gerald
  • Category Medical
  • Subject Endocrinology & Metabolism

Do you have questions about this book?

Ask an expert!

Description eBook delivery & access Reviews
The longest running serial published by Academic Press continues its well-respected run with Volume 61, a special volume in which a guest editor has come on board and has assembled some well-known contributors who are international authorities in the field. Together they tackle some of the latest topics in the field such as riboflavin and folate biosynthesis, biotin and lipoic acid biosynthesis, nicotinamide adenine dinucleotide biosynthesis, biosynthesis of vitamin B6 and structurally related derivatives, pantothenic acid and coenzyme A biosynthesis, mechanistic biosynthesis of protein-derived redox cofactors, ascorbic acid biosynthesis, biosynthesis of menaquinone and ubiquinone - Vitamin B12 biosynthesis, biosynthesis of the methanogenic cofactors, and thiamin biosynthesis.