Combinatorial Chemistry, Part B
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Table of contents
- Table of Contentsv
- Contributors to Volume 369ix
- Prefacexiii
- Volumes in Seriesxv
- Section I: Analytical Techniques1
- Chapter 1. High-Throughput Parallel LC/UV/MS Analysis of Combinatorial Libraries3
- Chapter 2. Qualitative Colorimetric Tests for Solid Phase Synthesis21
- Section II: Directed Sorting Split-and-Pool Combinatorial Synthesis37
- Chapter 3. A Review of Solid-Phase Organic Synthesis on SynPhase’ Lanterns and SynPhase’ Crowns39
- Chapter 4. Directed Sorting Approach for the Synthesis of Large Combinatorial Libraries of Discrete75
- Chapter 5. Split-Mix Synthesis Using Macroscopic Solid Support Units99
- Chapter 6. The Encore Technique: A Novel Approach to Directed Split-and-Pool Combinatorial Synthesis112
- Section III: Linkers and Their Applications125
- Chapter 7. Multifunctional Linkers as an Efficient Tool for the Synthesis of Diverse Small Molecule127
- Chapter 8. The Development and Application of Tetrafluorophenol-Activated Resins for Rapid Amine Der151
- Chapter 9. The Traceless Solid-Phase Synthesis of Organic Molecules164
- Chapter 10. Unnatural Diamino Acid Derivatives as Scaffolds for Creating Diversity and as Linkers fo182
- Section IV: Microwave-Assisted Synthesis195
- Chapter 11. Building Dihydropyrimidine Libraries via Microwave-Assisted Biginelli Multicomponent Rea197
- Chapter 12. Microwave-Assisted Solid-Phase Organic Synthesis (MA-SPOS) of Oxazolidinone Antimicrobia223
- Section V: Oligosaccharide Chemistry233
- Chapter 13. Automated Synthesis of Polysaccharides235
- Chapter 14. Solid-Phase Oligosaccharide Chemistry and Its Application to Library Synthesis248
- Section VI: Peptide Synthesis and Screening269
- Chapter 15. Design, Synthesis, Screening, and Decoding of Encoded One-Bead One-Compound Peptidomimet271
- Chapter 16. Intelligent Design in Combinatorial Chemistry: Use of Designed Peptide Libraries to Expl288
- Chapter 17. Synthesis and Screening of ‘‘One-Bead One- Compound’’ Combinatorial Peptide Libr298
- Chapter 18. Synthetic Combinatorial Libraries as an Alternative Strategy for the Development of Nove322
- Section VII: Polymer-Assisted Approaches345
- Chapter 19. Advances in the Applications of Polymer- Supported Reagents for Organic Synthesis347
- Chapter 20. Advanced Polymer Reagents Based on Activated Reactants and Reactive Intermediates: Power366
- Chapter 21. Scavenger Resins in Solution-Phase CombiChem391
- Section VIII: Small Molecule and Heterocycle Synthesis413
- Chapter 22. Cyclative Cleavage Strategies for the Solid- Phase Synthesis of Heterocycles and Natural415
- Chapter 23. Derivatization Reactions of Heterocyclic Scaffolds on Solid Phase: Tools for the Synthes435
- Chapter 24. Library Generation via Post condensation Modifications of Isocyanide-Based Multicomponen469
- Chapter 25. Mixture-Based Combinatorial Libraries: From Peptides and Peptidomimetics to Small Molecu496
- Chapter 26. New Strategies for the Solid-Phase Synthesis of Highly Functionalized, Small Molecules:517
- Author Index529
- Subject Index559
Combinatorial Chemistry encompasses both the design of compounds for specific pharmacological use and the screening of molecules in high throughput automated tests to find active agents with specific functions.
*Analytical techniques
*Direct sorting split and pool combinatorial synthesis
*Linkers and their applications
*Microwave assisted synthesis
*Oligosaccharide chemistry
*Peptide Synthesis and Screening
*Polymer assisted approaches
*Small molecule and heterocycle synthesis
*Analytical techniques
*Direct sorting split and pool combinatorial synthesis
*Linkers and their applications
*Microwave assisted synthesis
*Oligosaccharide chemistry
*Peptide Synthesis and Screening
*Polymer assisted approaches
*Small molecule and heterocycle synthesis