Computational Neuroscience: Theoretical Insights into Brain Function: Theoretical Insights into Brain Function

Cisek, Paul; Drew, Trevor; Kalaska, John

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Table of contents
  • Cover
  • Contentsxi
  • List of Contributorsv
  • Prefaceix
  • Chapter 1. The neuronal transfer function: contributions from voltage- and time-dependent mechanisms1
  • The neuronal input/output function1
  • Using a white-noise input to reveal the neuronal input/output function2
  • The LN model3
  • The LN model accounts for the dendrite-to-soma input/output function4
  • Gain but not filtering adapts to the input variance4
  • Voltage- and time-dependent properties that underlie neuronal bandpass filtering6
  • Discussion9
  • Acknowledgments10
  • References10
  • Chapter 2. A simple growth model constructs critical avalanche networks13
  • Introduction13
  • The model15
  • Results16
  • Discussion18
  • Acknowledgments19
  • References19
  • Chapter 3. The dynamics of visual responses in the primary visual cortex21
  • Introduction21
  • Theories of orientation selectivity21
  • Models with cortical inhibition and excitation23
  • Cortical orientation dynamics25
  • Discussion: inhibition and selectivity28
  • Orientation selectivity and cortical circuits30
  • Acknowledgments30
  • References30
  • Chapter 4. A quantitative theory of immediate visual recognition33
  • Introduction33
  • A quantitative framework for the ventral stream35
  • Comparison with physiological observations40
  • Performance on natural images47
  • Discussion50
  • Acknowledgments54
  • References54
  • Chapter 5. Attention in hierarchical models of object recognition57
  • Introduction57
  • Hierarchical models of object recognition58
  • A unifying framework for attention and object recognition (UNI)61
  • Mechanisms of attention65
  • Sharing features between object detection and top-down attention70
  • Conclusions75
  • Acknowledgments75
  • References75
  • Chapter 6. Towards a unified theory of neocortex: laminar cortical circuits for vision and cognition79
  • Introduction80
  • Complementary Computing and Laminar Computing80
  • Laminar computing by visual cortex: unifying adaptive filtering, grouping, and attention82
  • A new way to compute: feedforward and feedback, speed and uncertainty, digital and analog84
  • Linking stable development to synchrony85
  • Attention arises from top-down cooperative-competitive matching86
  • The preattentive–attentive interface and object-based attention86
  • Stable development and learning through adaptive resonance89
  • The link between attention and learning90
  • View-invariant object category learning: coordinating object attention and surface-based spatial att90
  • Learning without attention: the preattentive grouping is its own attentional prime92
  • Balanced excitatory and inhibitory circuits as a cortical design principle93
  • A synthesis of 3D vision, attention, and grouping94
  • Habituation, development, reset, and bistability98
  • Towards a unified theory of laminar neocortex: from vision to cognition99
  • Acknowledgments100
  • References100
  • Chapter 7. Real-time neural coding of memory105
  • Introduction: seeking the neural code105
  • Brief history of memory research107
  • In search of memory traces108
  • Visualizing network-level memory traces109
  • Identification of neural cliques as real-time memory-coding units113
  • Hierarchical and categorical organization of memory-encoding neural clique assemblies113
  • Universal activation codes for the brain’s real-time neural representations across individuals and117
  • Acknowledgments120
  • References120
  • Chapter 8. Beyond timing in the auditory brainstem: intensity coding in the avian cochlear nucleus a123
  • Introduction123
  • Morphological and physiological characteristics of the neurons of the cochlear nuclei125
  • Synaptic mechanisms in NA mediate parallel processing of intensity and timing information125
  • Functional roles for NA in coding sound intensity: a multi-faceted nucleus130
  • Conclusions131
  • Abbreviations131
  • Acknowledgment131
  • References131
  • Chapter 9. Neural strategies for optimal processing of sensory signals135
  • Introduction135
  • Structure of the ELL (Fig. 3)141
  • Physiology of the ELL143
  • Summary150
  • Acknowledgments150
  • References151
  • Chapter 10. Coordinate transformations and sensory integration in the detection of spatial orientati155
  • Introduction155
  • Conclusions from behavioral studies157
  • Theory159
  • Model description161
  • Model predictions163
  • Comparison with experimentally observed neural responses172
  • Discussion175
  • References178
  • Chapter 11. Sensorimotor optimization in higher dimensions181
  • Noncommutativity in the brain182
  • Optimizing gaze control in three dimensions184
  • The motor side of depth vision186
  • Conclusion189
  • Acknowledgments189
  • References190
  • Chapter 12. How tightly tuned are network parameters? Insight from computational and experimental st193
  • Compensating conductances in a two-cell network193
  • Building models to capture the dynamics of real neurons195
  • Biological variability in synaptic and intrinsic conductances196
  • Constructing model families197
  • Acknowledgments199
  • References199
  • Chapter 13. Spatial organization and state-dependent mechanisms for respiratory rhythm and pattern g201
  • Introduction202
  • Experimental studies204
  • Computational modeling of the brainstem respiratory network206
  • Discussion213
  • Acknowledgments215
  • References218
  • Chapter 14. Modeling a vertebrate motor system: pattern generation, steering and control of body ori221
  • Introduction221
  • Modeling of the segmental CPG223
  • Modeling of intersegmental coordination225
  • Steering228
  • Control of body orientation230
  • Sensory feedback helps compensate for perturbations231
  • Concluding remarks231
  • Acknowledgments232
  • References232
  • Chapter 15. Modeling the mammalian locomotor CPG: insights from mistakes and perturbations235
  • Introduction235
  • The role of intrinsic neuronal properties and reciprocal inhibition in rhythm generation236
  • Structure and operation of the locomotor model241
  • Control of cycle period and phase duration243
  • Insights into CPG organization from deletions of motoneuron activity during fictive locomotion245
  • Afferent control of the CPG at the PF and RG levels247
  • Conclusions250
  • Acknowledgments251
  • References251
  • Chapter 16. The neuromechanical tuning hypothesis255
  • Introduction: historical development and overview255
  • Sensory inputs in mammals257
  • Locomotor stretch reflexes257
  • Phase switching with If–Then sensory rules increases stability258
  • Control of locomotor phase durations within the CPG260
  • Sensory control of phase durations during locomotion261
  • Conclusions: general propositions263
  • Epilogue263
  • Acknowledgments263
  • References263
  • Chapter 17. Threshold position control and the principle of minimal interaction in motor actions267
  • Introduction267
  • Physiological origin of threshold position control269
  • Neural basis for other forms of threshold position control271
  • Experimental identification of task-specific referent body configurations and other tests276
  • Conclusions279
  • Abbreviations279
  • Acknowledgments279
  • Appendix A. Supplementary data279
  • References279
  • Chapter 18. Modeling sensorimotor control of human upright stance283
  • Introduction283
  • Sensors and sensory interaction principles in spatially oriented behavior284
  • Sensor fusions in the sensorimotor control model285
  • Embodiment of control principles into humanoid289
  • Control engineering approach290
  • Artificial vestibular system291
  • Discussion292
  • Acknowledgments296
  • References296
  • Chapter 19. Dimensional reduction in sensorimotor systems: a framework for understanding muscle coor299
  • Degrees of freedom problem300
  • Hierarchal feedback model of postural control307
  • Abbreviations316
  • Acknowledgments317
  • References317
  • Chapter 20. Primitives, premotor drives, and pattern generation: a combined computational and neuroe323
  • Introduction323
  • Modularity from a neuroethological perspective323
  • Degrees of freedom problem and evolution324
  • Forms of Modularity in the motor system325
  • Force-field primitives, premotor drives, and reflex effects: a computational framework326
  • Relations among primitives and pattern generators331
  • Detecting primitives and pattern generators in EMG behaviors333
  • Rhythmic motor patterns in rat locomotion333
  • Detecting oscillator interactions and timing336
  • Discussion340
  • Conclusions343
  • Acknowledgments343
  • References343
  • Chapter 21. A multi-level approach to understanding upper limb function347
  • Introduction347
  • Section 1: Global features of upper limb mechanics348
  • Section 2: Task-related activity of upper limb muscles351
  • Section 3: Relation to motor cortical processing355
  • Summary and interpretation357
  • Abbreviations360
  • Acknowledgments360
  • References360
  • Chapter 22. How is somatosensory information used to adapt to changes in the mechanical environment?363
  • Introduction363
  • Methods365
  • Results366
  • Discussion370
  • Acknowledgments372
  • References372
  • Chapter 23. Trial-by-trial motor adaptation: a window into elemental neural computation373
  • Introduction373
  • Motor learning of external dynamics373
  • Experience-dependent flexibility of error generalization375
  • Discussion378
  • References380
  • Chapter 24. Towards a computational neuropsychology of action383
  • Introduction383
  • Seeking rewards and observing the consequences of action384
  • What motivated HM to learn the reach adaptation task?386
  • Learning sensory consequences of motor commands vs. learning optimum control policies387
  • Apraxia and the case of patient BG388
  • Acknowledgments392
  • References392
  • Chapter 25. Motor control in a meta-network with attractor dynamics395
  • Introduction395
  • Methods397
  • Results405
  • Discussion407
  • Acknowledgments409
  • References409
  • Chapter 26. Computing movement geometry: a step in sensory-motor transformations411
  • Introduction411
  • Background412
  • Implementing the model412
  • Computing the gradient413
  • The gradient method414
  • Generalization of the model416
  • Fitting the model to experimental data417
  • Error correction419
  • Experimental tests420
  • The model and the brain421
  • Conclusions423
  • References423
  • Chapter 27. Dynamics systems vs. optimal control „ a unifying view425
  • Introduction425
  • Discrete and rhythmic movement - are they the same?428
  • Discrete and rhythmic movement: a computational model434
  • Discussion441
  • Acknowledgments443
  • References443
  • Chapter 28. The place of ’codes’ in nonlinear neurodynamics447
  • Introduction447
  • The neurodynamical paradigm449
  • The network approach: information processing and linear causality450
  • The field approach: the action-perception cycle451
  • Circular causality453
  • The continuity of circular causality across all levels455
  • From sensation to perception to conception; from goal to plan to action456
  • First intention and second intention458
  • Conclusions459
  • References461
  • Chapter 29. From a representation of behavior to the concept of cognitive syntax: a theoretical fram463
  • Task description464
  • Model description465
  • Possible correspondence between executive units and brain structures468
  • Comparison with other models470
  • Task representation and its emergence471
  • Abbreviations473
  • Acknowledgments473
  • References473
  • Chapter 30. A parallel framework for interactive behavior475
  • Do neural systems classify into perception, cognition, and action?475
  • A parallel framework for interactive behavior477
  • A computational model of simple decisions480
  • Model simulations482
  • Discussion488
  • Acknowledgments489
  • References489
  • Chapter 31. Statistical models for neural encoding, decoding, and optimal stimulus design493
  • Introduction493
  • Neural encoding models494
  • Optimal model-based spike train decoding499
  • Optimal model-based closed-loop stimulus design503
  • Conclusion506
  • Acknowledgments506
  • References506
  • Chapter 32. Probabilistic population codes and the exponential family of distributions509
  • Introduction509
  • Probabilistic Population Codes511
  • Discussion517
  • References519
  • Chapter 33. On the challenge of learning complex functions521
  • Introduction521
  • The problem with shallow architectures524
  • The problem with template matching and local kernels525
  • Learning abstractions one on top of the other530
  • What is needed531
  • Conclusion532
  • Acknowledgments533
  • References533
  • Chapter 34. To recognize shapes, first learn to generate images535
  • Five strategies for learning multilayer networks535
  • Learning feature detectors with no supervision538
  • Learning one layer of feature detectors539
  • A greedy learning algorithm for multiple hidden layers540
  • Using backpropagation for discriminative fine-tuning541
  • Using contrastive wake-sleep for generative fine-tuning543
  • Acknowledgments546
  • References546
Book details
  • Vendor Elsevier S & T
  • SKU 9780444528230
  • ISBN-13 9780080555027
  • Author Cisek, Paul; Drew, Trevor; Kalaska, John
  • Category Medical
  • Subject Neuroscience

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Computational neuroscience is a relatively new but rapidly expanding area of research which is becoming increasingly influential in shaping the way scientists think about the brain. Computational approaches have been applied at all levels of analysis, from detailed models of single-channel function, transmembrane currents, single-cell electrical activity, and neural signaling to broad theories of sensory perception, memory, and cognition. This book provides a snapshot of this exciting new field by bringing together chapters on a diversity of topics from some of its most important contributors. This includes chapters on neural coding in single cells, in small networks, and across the entire cerebral cortex, visual processing from the retina to object recognition, neural processing of auditory, vestibular, and electromagnetic stimuli, pattern generation, voluntary movement and posture, motor learning, decision-making and cognition, and algorithms for pattern recognition. Each chapter provides a bridge between a body of data on neural function and a mathematical approach used to interpret and explain that data. These contributions demonstrate how computational approaches have become an essential tool which is integral in many aspects of brain science, from the interpretation of data to the design of new experiments, and to the growth of our understanding of neural function.

• Includes contributions by some of the most influential people in the field of computational neuroscience
• Demonstrates how computational approaches are being used today to interpret experimental data
• Covers a wide range of topics from single neurons, to neural systems, to abstract models of learning