Elsevier S & T

Current Topics in Cellular Regulation

Stadtman, Earl R.

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Table of contents
  • CURRENT TOPICS IN Cellular Regulationiii
  • Copyright Pageiv
  • Contentsv
  • Chapter 1. Regulation of Iron Metabolism in Eukaryotes1
  • I. Need for Regulation of Iron Metabolism1
  • II. Translational Regulation of the Iron Sequestration Protein Ferritin2
  • III. Expression of TfR Regulated by Intracellular Iron Levels3
  • IV. IREs as Binding Sites for IRP3
  • V. Steric Hindrance Model to Account for Function of IRP1 in Regulation4
  • VI. Iron-Sulfur Cluster of IRP1 as Key to Sensing of the Iron Levels5
  • VII. Residues in Active Site Cleft Essential in IRE Binding6
  • VIII. Role of IRP1 in Vivo8
  • IX. Assembly and Disassembly of Iron-Sulfur Cluster of IRP18
  • X. IRP2 as Ubiquitous IRE Binding Protein Regulated by Degradation When Iron Levels Are High9
  • XI. Cysteines Indispensable to Function of Degradation Domain10
  • XII. IRPs Expressed in Cells: Redundant Function or Undefined Unique Roles11
  • XIII. Differences in IRE Binding Sites of IRP1 and IRP2 Permit IRPs to Bind Unique Targets12
  • XIV. Role for IRE Mutations in Human Disease13
  • XV. Speculations on Evolution of IRPs13
  • XVI. Other Genes That May Be Regulated by IRE-IRP Regulatory System14
  • XVII. Summary and Conclusions16
  • References16
  • Chapter 2. Structure, Mechanism, and Specificity of Protein-Tyrosine Phosphatases21
  • I. Introduction21
  • II. Structural Characterization25
  • III. Catalytic Mechanism30
  • IV. Substrate Specificity48
  • V. Conclusion and Perspective62
  • References63
  • Chapter 3. Regulation of Fas-Mediated Apoptosis69
  • I. Introduction69
  • II. Regulatory Factors72
  • III. Regulation of Fas-Mediated Apoptosis86
  • IV. Conclusion92
  • References92
  • Chapter 4. Aging and Regulation of Apoptosis107
  • I. Introduction107
  • II. Genes Involved in Apoptosis108
  • III. Cell Senescence and Apoptosis110
  • IV. Immunological Aging and Apoptosis112
  • V. Caloric Restriction and Apoptosis114
  • VI. Neurodegenerative Disease and Apoptosis115
  • VII. Summary117
  • References119
  • Chapter 5. Gene Regulation by Reactive Oxygen Species123
  • I. Introduction123
  • II. Sensitivity of Transcription Factors to Intracellular Redox Changes124
  • III. Effects of Redox Changes on Regulation of Gene Expression134
  • IV. ROS and Extracellular Signal Transduction139
  • V. Concluding Remarks143
  • References144
  • Chapter 6. Regulation of NF-kB and Disease Control: Identification of a Novel Serine Kinase and Thio149
  • I. Introduction149
  • II. Transcription Factor NF-kB and Its Activation Pathways150
  • III. Involvement of NF-kB in Disease Processes153
  • IV. Screening Strategy for Anti-NF-kB Compounds157
  • V. Summary157
  • References158
  • Chapter 7. Regulation of Bacterial Responses to Oxidative Stress163
  • I. Introduction163
  • II. Regulators of Escherichia coli Responses to Oxidative Stress164
  • III. Oxidative Stress Responses in Salmonella, Haemophilus, Mycobacterium, and Bacillus169
  • IV. Concluding Remarks174
  • References175
  • Chapter 8. Mechanism and Regulation of Bone Resorption by Osteoclasts179
  • I. Historical Background and Future Prospects179
  • II. Suppression of Bone Resorption by Cathepsin L Family Inhibitors180
  • III. Functional Differentiation of Osteoclasts and Macrophages with Respect to Cathepsins L and B183
  • IV. Mechanism and Regulation of Procathepsin L Secretion from Osteoclasts184
  • V. Cathepsin L Secreted from Osteoclasts as Precursor Form and Processed by Cysteine Proteinase(s) i187
  • VI. Inhibitory Mechanisms of H+-ATPase, Carbonic Anhydrase II, and Monensin on Pit-Forming Assay188
  • VII. Suppression of Bone Resorption by Cathepsin L Family Inhibitors in Vivo189
  • VIII. Possible Strategies for New Drug Design to Protect Bone Resorption190
  • References191
  • Index193
Book details
  • Vendor Elsevier S & T
  • SKU 9780121528355
  • ISBN-13 9780080530161
  • Author Stadtman, Earl R.
  • Category Science
  • Subject Research & Methodology

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This informative publication brings together knowledge of various aspects of cellular regulation. Current Topics in Cellular Regulation reviews the progress being made in those specialized areas of study that have undergone substantial development. It also publishes provocative new theories and concepts and serves as a forum for the discussion of general principles. Researchers in cellular regulation as well as biochemists, molecular and cell biologists, microbiologists, and biophysicists will find Current Topics in Cellular Regulation a useful source of up-to-date information.

Key Features
* Regulation of Iron Metabolism in Eukaryotes
* Regulation of Fas-Mediated Apoptosis
* Aging and Regulation of Apoptosis
* Regulation of Bacterial Responses of Oxidaditive Stress
* Regulation of NF-(B and Disease Control
* Mechanism and Regulation of Bone Resorption
* Gene Regulation by Reactive Oxygen Species
* Structure, Mechanism, and Specificity of Protein-Tyrosine Phosphatases