Elsevier S & T

Current Topics in Developmental Biology

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Table of contents
  • Contentsv
  • Contributorsix
  • Prefacexi
  • Chapter 1. Early Events in the DNA Damage Response1
  • I. Introduction1
  • II. Formation of Multiprotein Complexes4
  • III. Concluding Remarks21
  • Acknowledgments22
  • References22
  • Chapter 2. Afrotherian Origins and Interrelationships: New Views and Future Prospects37
  • I. Introduction37
  • II. Morphological and Molecular Evidence40
  • III. Continental Drift, Cladistic Biogeography, and Afrotherian Origins44
  • IV. Rare Genomic Changes49
  • V. Conclusions52
  • References54
  • Chapter 3. The Role of Antisense Transcription in the Regulation of X-Inactivation61
  • I. Introduction61
  • II. Early Signs of Antisense Transcription within Xist66
  • III. Is There One Xist Antisense Transcript or Several?68
  • IV. Tsix Is Involved in Imprinted X-Inactivation69
  • V. Tsix Is Involved in Neither Counting nor Silencing71
  • VI. Is Tsix Involved in Choice?72
  • VII. A Role for Tsix in Xist Metabolism74
  • VIII. Mechanistic Insights into Tsix Function76
  • IX. Regulation of Tsix Transcription80
  • X. Is Tsix Functional Only in the Mouse?82
  • XI. Concluding Remarks82
  • References85
  • Chapter 4. The Genetics of Hiding the Corpse: Engulfment and Degradation of Apoptotic Cells in C. el91
  • I. Introduction91
  • II. Studies of Cell Corpse Engulfment in C. elegans94
  • III. The Degradation of Nuclear DNA During Programmed Cell Death in C. elegans121
  • IV. Study of Engulfment and DNA Degradation in Drosophila126
  • V. Concluding Remarks135
  • Acknowledgments136
  • References136
  • Chapter 5. Beginning and Ending an Actin Filament: Control at the Barbed End145
  • I. Introduction146
  • II. Locally Create a Free Barbed End148
  • III. Enhance Barbed-End Elongation167
  • IV. Capping Barbed Ends168
  • V. Replenish G-Actin Pool by Pointed-End Depolymerization of F-Actin175
  • VI. New Directions176
  • References177
  • Chapter 6. Life Extension in the Dwarf Mouse189
  • I. Introduction190
  • II. Origin and Phenotypic Characteristics of Mutant, Knockout, and Transgenic Dwarf Mice191
  • III. Longevity of Different Types of Dwarf Mice196
  • IV. Suspected Mechanisms of Prolonged Longevity200
  • V. Why Are Dwarf Mice Long-Lived? Single versus Multiple Mechanisms208
  • VI. How Do the Findings in Long-Lived Mutant Mice Fit into the ‘‘Big Picture’’? What Can Be210
  • VII. Breeding and Husbandry of Long-Lived Mutant Mice214
  • Reference215
  • Index227
  • Contents of Previous Volumes237
Book details
  • Vendor Elsevier S & T
  • SKU 9780121531638
  • ISBN-13 9780080494364

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Current Topics in Developmental Biology provides a comprehensive survey of the major topics in the field of developmental biology. The volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology.

This volume contains six important contributions from leading minds in developmental biology.

* Presents major contemporary issues and astonishing discoveries at the forefront of modern developmental biology, stem cells, cloning, and regenerative medicine
* Series Editor Gerald Schatten is one of the leading minds in reproductive and developmental science
* The longest-running forum for current issues in developmental biology with over 30 years of coverage