Elsevier S & T

Current Topics in Developmental Biology

Schatten, Gerald P.

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Table of contents
  • Contentsv
  • Contributorsix
  • Prefacexi
  • Chapter 1. Stem/Progenitor Cells in Lung Morphogenesis, Repair, and Regeneration1
  • I. Introduction1
  • II. Background3
  • III. Symposium Presentations and Discussion7
  • IV. Summary and Conclusions10
  • References11
  • Chapter 2. Lessons from a Canine Model of Compensatory Lung Growth17
  • I. Structure–Function Considerations during Compensation18
  • II. Dysanaptic Lung Growth23
  • III. Signals for Compensatory Lung Growth26
  • IV. Application to Human Lung Growth29
  • Acknowledgments29
  • References30
  • Chapter 3. Airway Glandular Development and Stem Cells33
  • I. Introduction and Scope34
  • II. Airway Submucosal Gland Structure/Function and Its Relationship to Human Diseases35
  • III. Species-Specific Differences in Conducting Surface Airway Epithelial Cell Types and Submucosal37
  • IV. Evidence for Human Adult Proximal Airway Stem Cells Capable of Developing Submucosal Glands41
  • V. Mouse Tracheal Injury Models Suggest Submucosal Gland Ducts Are a Niche for Proximal Airway Stem45
  • VI. Developmental Molecular Markers of Glandular Stem Cell Phenotypes46
  • VII. Concluding Remarks and Future Challenges51
  • Acknowledgments52
  • References52
  • Chapter 4. Gene Expression Studies in Lung Development and Lung Stem Cell Biology57
  • I. Introduction57
  • II. Verifying and Challenging Old Concepts59
  • III. Establishing New Concepts61
  • IV. A Model for Lung Alveogenesis62
  • V. Development and Stem Cells63
  • VI. Applying Developmental Transcriptional Modules to Adult Disease65
  • VII. Lung Cancer65
  • VIII. Conclusion66
  • Acknowledgments67
  • References67
  • Chapter 5. Mechanisms and Regulation of Lung Vascular Development73
  • I. Introduction73
  • II. Overview of Pulmonary Vessel Formation74
  • III. Regulation of Lung Vasculature Formation77
  • IV. Epithelial–Mesenchymal Interactions during Lung Vascular Development85
  • V. Specification of Arterio-Venous Identity86
  • VI. Endothelial Stem Cells in Lung Regeneration and Repair90
  • VII. Conclusions91
  • Acknowledgments92
  • References92
  • Chapter 6. The Engineering of Tissues Using Progenitor Cells101
  • I. The Parenchyma: An Interactive Cell Population102
  • II. A Working Hypothesis for Understanding Parenchymal Cell Interaction and Response103
  • III. The Epidermis105
  • IV. The Liver116
  • V. The Pancreas and Generation of Pancreatic Islets125
  • VI. Conclusions and Future Directions130
  • References131
  • Chapter 7. Adult Bone Marrow-Derived Hemangioblasts, Endothelial Cell Progenitors, and EPCs141
  • I. Introduction142
  • II. Stem and Progenitor Cells143
  • III. Embryonic Hemangioblasts145
  • IV. Adult Angioblasts148
  • V. Adult Hemangioblasts152
  • VI. Physiological Significance of Bone Marrow-Derived Endothelium154
  • VII. Endothelial Cell Progenitors156
  • VIII. Mobilization160
  • IX. Bone Marrow-Induced Functional Improvements in Ischemic Tissue163
  • X. Are We Ready for Human Trials?165
  • XI. Looking to the Future167
  • Acknowledgments168
  • References168
  • Chapter 8. Synthetic Extracellular Matrices for Tissue Engineering and Regeneration181
  • I. Introduction182
  • II. Inductive and Cell Transplantation Strategies187
  • III. Engineering Vascular Structures191
  • IV. Bone Regeneration196
  • V. Conclusions and Future Directions199
  • Acknowledgments200
  • References200
  • Chapter 9. Integrins and Angiogenesis207
  • I. Introduction208
  • II. Endothelial Cell Integrins209
  • III. Initiation of Angiogenesis214
  • IV. Alterations in Integrin–ECM Interactions During Angiogenesis218
  • V. Integrin Antagonists Effects versus the Phenotype of Knockout Animals227
  • VI. Perspective and Conclusions228
  • References230
  • Index239
  • Contents of Previous Volumes249
Book details
  • Vendor Elsevier S & T
  • SKU 9780121531645
  • ISBN-13 9780080494371
  • Author Schatten, Gerald P.
  • Category Science
  • Subject Developmental Biology

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Current Topics in Developmental Biology provides a comprehensive survey of the major topics in the field of developmental biology. The volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology.

This volume contains nine important contributions from leading minds in developmental biology.

* Presents major contemporary issues and astonishing discoveries at the forefront of modern developmental biology, stem cells, cloning, and regenerative medicine
* Series Editor Gerald Schatten is one of the leading minds in reproductive and developmental science
* The longest-running forum for current issues in developmental biology with over 30 years of coverage