Current Topics in Developmental Biology
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Table of contents
- Contentsv
- Contributorsix
- Chapter 1: The Development of Synovial Joints1
- I. Introduction2
- A. Joint Morphogenesis: Overview4
- II. Specification and Patterning of the Joint5
- A. The Limb Field and Joints5
- B. Formation of the Joint Interzone9
- III. Joint Cavitation and the Role of Mechanical Stimuli13
- IV. Cell-Matrix Interactions During Joint Formation19
- V. The Development of Articular Cartilage: Overview22
- VI. Aspects of Postnatal Joint Biology23
- References28
- Chapter 2: Development of a Sexually Differentiated Behavior and Its Underlying CNS Arousal Function37
- I. Introduction38
- II. Sexual Differentiation of Brain Mechanisms Producing Lordosis Behavior41
- A. Mechanisms42
- III. Development of Brain Mechanisms Underlying Arousal53
- IV. Outlook for New Work on Sexually Differentiated Behaviors54
- References56
- Chapter 3: Phosphodiesterases Regulate Airway Smooth Muscle Function in Health and Disease61
- I. Introduction61
- II. Developmental and Physiological Responses Regulated by PDEs65
- III. PDEs and Airway Smooth Muscle Function67
- A. PDE and ASM Tone and Contractility67
- B. PDE and ASM Growth and Migration68
- IV. Cytokine and Chemokine Secretion by ASM: A Role for PDEs69
- V. Conclusions70
- Acknowledgments70
- References71
- Chapter 4: Role of Astrocytes in Matching Blood Flow to Neuronal Activity75
- I. Introduction76
- II. Neurovascular Unit76
- III. Neuron-Astrocyte Interactions and Regulation of Synaptic Transmission in the Brain78
- A. Ca2+ Signaling in Astrocytes78
- B. Astrocyte Release of Glutamate and Modulation of Synaptic Transmission80
- C. Neurometabolic Coupling81
- IV. Neurovascular Coupling: Role of Astrocytes82
- A. Role of Astrocytic Ca2+ Elevations in Coupling Neuronal Activity to the Vasculature82
- B. Vasoactive Mediators of Neurovascular Coupling84
- V. Summary89
- References90
- Chapter 5: Elastin-Elastases and Inflamm-Aging99
- I. Introduction100
- A. The MMPs: Cytokines Interplay in Inflammation101
- B. MMPs as Matrix "Decryptases"102
- C. Elastic Fibers Fragmentation and Aging103
- II. Elastic Fibers: Formation and Degradation103
- A. Synthesis and Association (Coacervation) of Tropoelastin Molecules103
- B. Development of Elastic Fibers105
- C. Elastases in Human106
- D. Mechanism of Elastin Degradation by Elastases110
- III. Biological Activities of Elastin Peptides (EPs): The "Elastin Receptor System"111
- A. EPs as Modifiers of Cell Behavior111
- B. The S-Gal Complex114
- C. Cell Signaling Pathways Mediated by S-Gal Occupancy115
- IV. Elastolysis, Aging, and AAAs117
- A. Elastase(s)-Driven Elastin Fragmentation in Arterial Diseases: General Considerations117
- B. Proangiogenic Effect of EPs118
- C. Influence of EPs on T-Lymphocytes Polarization124
- V. The Elastin Connection in Melanoma127
- A. Aging, Fibroblasts Senescence, and Cancer Progression127
- B. EPs as Modifiers of the Dermal Stroma128
- C. EPs and Melanoma Progression129
- D. EPs-Mediated Angiogenic Phenotype131
- E. EPs and Inflamm-Aging in Melanoma133
- VI. Concluding Remarks135
- References138
- Chapter 6: A Phylogenetic Approach to Mapping Cell Fate157
- I. Development158
- II. Fate Maps159
- A. Fate Maps from Direct Observation159
- B. Mapping Development with Interspecies Chimeras159
- C. Tracing Cell Lineage Through Cell Marking159
- D. Cell Marking with Genetic Markers161
- III. Limited Information from Cell Marking165
- IV. Stochastic Nature of Development in Higher Organisms168
- V. A New Approach: Phylogenetic Fate Mapping171
- A. Introduction to Phylogenetics171
- B. Somatic Mutations173
- C. Tests in Cell Culture174
- D. Mapping Lineages in Whole Organisms176
- VI. Challenges Dealing with Randomness in Development177
- VII. Extended Applications of Phylogenetic Fate Mapping179
- Acknowledgments180
- References180
- Index185
This serial provides a comprehensive survey of the major topics in the field of developmental biology. These volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology.
* Includes many descriptive figures
* Topics covered include the the development of synovial joints, sexually differentiated behavior, mapping cell fate, and more
* Latest volume in the series that covers six reviews in more than 220 pages
* Includes many descriptive figures
* Topics covered include the the development of synovial joints, sexually differentiated behavior, mapping cell fate, and more
* Latest volume in the series that covers six reviews in more than 220 pages