Current Topics in Developmental Biology
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Table of contents
- Copyright Pageiv
- Contentsv
- Contributorsix
- Chapter 1. Selfishness in Moderation: Evolutionary Success of the Yeast Plasmid1
- I. Introduction2
- II. The Origins and Evolution of Selfishness2
- III. Selfish Nucleic Acids in Prokaryotes and Eukaryotes3
- IV. The Yeast Plasmids5
- V. Organization and Regulation of the 2-µm Circle Genome5
- VI. The Plasmid Partitioning and Amplification Systems6
- VII. Regulation of Plasmid Gene Expression7
- VIII. The Yeast Cohesin Complex Interacts Specifically with the Rep–STB System15
- IX. Models for Cohesin-Mediated Plasmid Segregation17
- X. Summary and Perspectives18
- XI. Open Questions for Future Research19
- References21
- Chapter 2. Nongenomic Actions of Androgen in Sertoli Cells25
- I. Introduction26
- II. Hormonal Regulation of Spermatogenesis27
- III. Nongenomic Actions of Androgen30
- IV. The Regulation of Female and Male Germ Cell Development by Nongenomic Actions of Androgen38
- V. Summary46
- Acknowledgments46
- References46
- Chapter 3. Regulation of Chromatin Structure and Gene Activity by Poly(ADP-Ribose) Polymerases55
- I. Introduction56
- II. Background56
- III. Mechanism of Action63
- IV. Poly(ADP-Ribose) Polymerase and Transcription66
- V. Multiple Routes to Poly(ADP-Ribose) Polymerase Activation70
- VI. Specificity of Transcriptional Activation72
- VII. Poly(ADP-Ribose) Polymerase and Other Chromatin Processes73
- VIII. Concluding Thoughts75
- Acknowledgments76
- References76
- Chapter 4. Centrosomes and Kinetochores, Who Needs ’Em? The Role of Noncentromeric Chromatin in Sp85
- I. Introduction85
- II. Role of Centrosomes and Kinetochores in Spindle Assembly86
- III. Role of Chromatin in Spindle Assembly88
- IV. How Does Chromatin Stabilize Microtubules?91
- V. Chromatin-Associated Kinases and Microtubules91
- VI. Chromatin-Associated Phosphatases and Microtubule Dynamics94
- VII. The Elusive Chromatin Signal: RanGTP95
- VIII. RCC1, the Chromatin Regulator of Microtubules96
- IX. The RanGTP Gradient97
- X. Ran and Microtubule Stabilization and Organization98
- XI. Ran and Microtubule Nucleation101
- XII. Ran and Chromosome Condensation102
- XIII. Chromatin-Associated Microtubule-Based Motor Proteins and Spindle Assembly102
- XIV. Centrosomes and Kinetochores Revisited105
- XV. Conclusions106
- Acknowledgments107
- References107
- Chapter 5. Modeling Cardiogenesis: The Challenges and Promises of 3D Reconstruction115
- I. Introduction115
- II. Embryonic Heart Development in Mammals117
- III. Reconstruction and Modeling Techniques118
- IV. The Embryonic Human Heart128
- V. Recent Developments132
- VI. Summary and Future Directions138
- References140
- Chapter 6. Plasmid and Chromosome Traffic Control: How ParA and ParB Drive Partition145
- I. Introduction: Chromosome Dynamics in Bacterial Cells145
- II. P1 ParA and ParB146
- III. Other Plasmid Partition Systems163
- IV. Bacterial ParA and ParB Proteins168
- V. Concluding Remarks173
- Acknowledgments174
- References174
- Index181
- Contents of Previous Volumes197
Together with other volumes in this series, Volume 56 presents thoughtful and forward-looking articles on developmental biology and developmental medicine.
Reviews include:
* Selfishness in moderation: evolutionary success of the yeast plasmid
* Nongenomic actions of androgen in sertoli cells
* Regulation of chromatin structure and gene activity by Poly(ADP-ribose) polymerases
* Centromeres and Kinetochores, Who Needs 'Em? The Role of Non-centromeric Chromatin in Spindle Assembly
* Modeling Cardiogenesis: The Challenges and Promises of 3D Reconstruction
* Plasmid and Chromosome Traffic Control: How ParA and ParB Drive Partition
The exceptional reviews in this volume of Current Topics in Developmental Biology will be valuable to both clinical and fundamental researchers, as well as students and other professionals who want an introduction to current topics in cellular and molecular approaches to developmental biology and clinical problems of aberrant development.
* Series Editor Gerald Schatten is one of the leading minds in reproductive and developmental science
* Presents major issues and astonishing discoveries at the forefront of modern developmental biology and developmental medicine
* The longest-running forum for contemporary issues in developmental biology with over 30 years of coverage
Reviews include:
* Selfishness in moderation: evolutionary success of the yeast plasmid
* Nongenomic actions of androgen in sertoli cells
* Regulation of chromatin structure and gene activity by Poly(ADP-ribose) polymerases
* Centromeres and Kinetochores, Who Needs 'Em? The Role of Non-centromeric Chromatin in Spindle Assembly
* Modeling Cardiogenesis: The Challenges and Promises of 3D Reconstruction
* Plasmid and Chromosome Traffic Control: How ParA and ParB Drive Partition
The exceptional reviews in this volume of Current Topics in Developmental Biology will be valuable to both clinical and fundamental researchers, as well as students and other professionals who want an introduction to current topics in cellular and molecular approaches to developmental biology and clinical problems of aberrant development.
* Series Editor Gerald Schatten is one of the leading minds in reproductive and developmental science
* Presents major issues and astonishing discoveries at the forefront of modern developmental biology and developmental medicine
* The longest-running forum for contemporary issues in developmental biology with over 30 years of coverage