Elsevier S & T

Cytokines

Mire-Sluis, Anthony R.; Thorpe, Robin

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Table of contents

Cover
Contentsv
Contributorsxvii
Prefacexxiii
Chapter 1. Interleukin 11
1. Introduction1
2. The Cytokine Gene2
3. Proteins6
4. Cellular Sources and Production8
5. Biological Activities8
6. Receptors and Signal Transduction10
7. Transduction Pathways11
8. Mouse IL-112
9. IL-1 Receptor Antagonist (IL-1Ra)12
10. Clinical Implications13
11. References13
Chapter 2. Interleukin-219
1. Introduction19
2. The IL-2 Gene20
3. The IL-2 Protein
4. Cellular Sources and Production
5. Biological Activity
6. The IL-2 Receptor
7. Receptor Expression and Signal Transduction
8. IL-2-IL-2R Involvement in Disease
9. IL-2 Therapy
10. Acknowledgments
11. References
Chapter 3. Interleukin-335
1. Introduction35
2. The Cytokine Gene36
3. The Protein37
4. Cellular Sources and Production38
5. Biological Activity38
6. The Receptor42
7. Signal Transduction43
8. Murine Cytokine43
9. IL-3 in Disease and Therapy45
10. References46
Chapter 4. Interleukin-453
1. Introduction53
2. The Cytokine Gene53
3. The Protein55
4. Cellular Sources and Production55
5. Biological Activity56
6. IL-4 Receptor57
7. Signal Transduction59
8. Murine IL-459
9. IL-4 in Disease and Therapy60
10. References61
Chapter 5. Interleukin-569
1. Introduction69
2. Gene Structure and Expression70
3. Protein Structure71
4. Cellular Sources73
5. Biological Activities74
6. IL-5 Receptor76
7. Signal Transduction Pathway79
8. Clinical Implications79
9. References80
Chapter 6. Interleukin-687
1. Introduction87
2. The IL-6 Gene88
3. The IL-6 Protein90
4. Cellular Sources and Production92
5. Biological Activities of IL-692
6. Receptors95
7. Signal Transduction and Gene Regulation97
8. Murine IL-6, Transgenics and Knockouts98
9. Clinical Implications99
10. References100
Chapter 7. Interleukin-7109
1. Introduction109
2. The IL-7 Gene110
3. IL-7 Protein112
4. Cellular Sources113
5. Biological Activities113
6. IL-7 Receptors116
7. IL-7 Signal Transduction118
8. Clinical Applications118
9. References119
Chapter 8. Interleukin-8125
1. Introduction125
2. The Cytokine Gene126
3. The Protein126
4. Cellular Sources and Production129
5. Biological Activities130
6. The IL-8 Receptors131
7. Signal Transduction133
8. Clinical Implications134
9. References134
Chapter 9. Interleukin-9141
1. Introduction141
2. The IL-9 Gene: Structure and Expression142
3. Characterization of the IL-9 Protein142
4. Cellular Sources and Regulation of IL-9 Expression143
5. Biological Activities of IL-9144
6. The IL-9 Receptor145
7. Signal Transduction145
8. Murine IL-9146
9. Putative Involvement of IL-9 in Pathology147
10. References148
Chapter 10. InterIeukin-10151
1. Introduction151
2. The Cytokine Gene152
3. The Protein153
4. Cellular Sources and Production154
5. Biological Activities155
6. The Receptor158
7. Signal Transduction159
8. Murine IL-10159
9. Cytokine in Disease and Therapy160
10. References161
Chapter 11. Interleukin-l l169
1. Introduction169
2. The IL-11 Gene170
3. The IL-11 Protein170
4. Cellular Sources of IL-11172
5. In vitro Effects of IL-11173
6. The IL-11 Receptor177
7. IL-11 Signal Transduction177
8. Clinical Implications178
9. Summary179
10. References179
Chapter 12. Interleukin-12183
1. Introduction183
2. The IL-12 Genes184
3. The Protein186
4. Sources of IL-12189
5. Biological Activities189
6. IL-12 Receptor193
7. Clinical Implications195
8. References198
Chapter 13. Interleukin-13205
1. Introduction205
2. The Cytokine Gene206
3. The Protein206
4. Cellular Sources and Production208
5. Biological Activity208
6. IL-13 Receptor209
7. Signal Transduction211
8. Murine IL-13211
9. IL-13 in Disease and Therapy211
10. References212
Chapter 14. Interleukin-14217
Preface217
1. Introduction217
2. The Cytokine Gene217
3. The Protein218
4. The Receptor219
5. References219
Chapter 15. Interleukin-15221
1. Introduction221
2. The Cytokine Gene221
3. The Protein222
4. Cellular Sources and Production222
5. Biological Activities222
6. The Receptor223
7. Signal Transduction224
8. Cytokine in Disease and Therapy225
9. References225
Chapter 16. Interleukin-16227
Chapter 17. Granulocyte Colony-stimulating Factor231
1. Introduction231
2. The Cytokine Gene232
3. The Protein234
4. Cellular Sources and Production237
5. Biological Activities237
6. Receptors238
7. Signal Transduction238
8. Clinical Applications239
9. References241
Chapter 18. Macrophage Colony-stimulating Factor245
1. Introduction245
2. The Cytokine Gene246
3. The Protein246
4. Cellular Sources and Production249
5. Cellular and Animal Biological Activity249
6. M-CSF Receptors252
7. Signal Transduction252
8. MurineM-CSF253
9. M-CSF in Therapy253
10. Summary255
11. References255
Chapter 19. Granulocyte-Macrophage Colony-stimulating Factor261
1. Introduction261
2. The Cytokine Gene261
3. The GM-CSF Protein263
4. Cellular Sources and Production264
5. Biological Activities264
6. The GM-CSF Receptor266
7. Signal Transduction268
8. Murine GM-CSF268
9. GM-CSF in Disease and Therapy269
10. References270
Chapter 20. Leukemia lnhibitory Factor277
1. Introduction277
2. The Cytokine Gene278
3. The Protein278
4. Cellular Sources and Production280
5. Biological Activity281
6. The Receptor284
7. Signal Transduction286
8. Murine Cytokine287
9. Cytokine in Disease and Therapy287
10. Acknowledgments288
11. References288
Chapter 21. The Steel Factor/kit Ligand/Stem Cell Factor297
1. Introduction297
2. The Gene298
3. The Protein300
4. Cellular Sources and Production301
5. Biological Activities303
6. The c-kit Receptor309
7. Signal Transduction through the c-kit Receptor310
8. Steel Factor from Other Sources311
9. Clinical Implications312
10. Acknowledgments312
11. References312
Chapter 22. flt3 Ligand321
1. Introduction321
2. The Cytokine Gene321
3. The Protein322
4. Cellular Sources323
5. Biological Activities323
6. The Receptor324
7. Cytokine in Disease and Therapy325
8. References325
Chapter 23. Thrombopoietin327
1. Introduction327
2. The Cytokine Gene328
3. The Protein329
4. Cellular Sources330
5. Biological Activities330
6. The Receptor331
7. Signal Transduction331
8. Cytokine in Disease and Therapy332
9. References332
Chapter 24. Tumor Necrosis Factor and Lymphotoxin335
1. Introduction335
2. The TNF and LT Genes336
3. Protein Structure338
4. Cellular Sources and Production340
5. Biological Activities341
6. Receptors345
7. Signal Transduction347
8. Murine TNF and Murine LT348
9. TNF in Disease and Therapy348
10. Acknowledgments351
11. References351
Chapter 25. Interferons Alpha, Beta, and Omega361
1. Introduction361
2. IFN Genes363
3. IFN Proteins367
4. Cellular Sources and Production369
5. Biological Activities Associated with IFN-α/β/ω370
6. Receptors372
7. Signal Transduction375
8. Mouse IFN-α and IFN-β376
9. Clinical Uses of IFNs378
10. References380
Chapter 26. Interferon-Gamma391
1. Introduction391
2. The Cytokine Gene392
3. The Protein392
4. Cellular Sources and Production393
5. Biological Activity394
6. The Receptor395
7. Signal Transduction396
8. The Murine Cytokine397
9. Interferon-γ in Disease and Therapy398
10. Acknowledgments398
11. References398
Chapter 27. Oncostatin M401
1. Introduction401
2. The Cytokine Gene402
3. The Protein402
4. Cellular Sources and Production404
5. Biological Activity404
6. OM Receptors407
7. Signal Transduction408
8. Mouse OM410
9. OM in Disease and Therapy410
10. Notes Added in Proof411
11. References411
Chapter 28. Transforming Growth Factor β415
1. Introduction415
2. The Cytokine Gene Family416
3. The Protein416
4. Cellular Sources and Production417
5. Biological Activity: Multifunctional Regulation419
6. The Receptors420
7. Signal Transduction420
8. Murine TGF-β423
9. TGF-β in Disease and Therapy424
10. References426
Chapter 29. RANTES433
1. Introduction434
2. The RANTES Gene434
3. The RANTES Protein436
4. Cellular Sources of RANTES437
5. Biological Activities439
6. RANTES Receptors441
7. Signal Transduction443
8. Murine RANTES443
9. RANTES in Disease and Therapy444
10. References445
Chapter 30. NAP-2/ENA-78449
1. Introduction449
2. The Cytokine Gene450
3. The Protein452
4. Cellular Sources and Production454
5. Biological Activities456
6. The Receptors458
7. Signal Transduction459
8. Cytokine in Disease and Therapy459
9. Acknowledgments461
10. References461
Chapter 31. Macrophage Inflammatory Protein 1-α467
1. Introduction467
2. The MIP-1α Gene468
3. The MIP-1α Protein469
4. Cellular Sources and Production473
5. Biological Activities474
6. Receptors476
7. Signal Transduction479
8. MIP-1α in Disease and Therapeutic Implications480
9. Summary482
10. References482
Chapter 32. Monocyte Chemotactic Proteins 1, 2 and 3489
1. Introduction489
2. The MCP Gene Sequences and Structure490
3. The MCP Proteins492
4. Cellular Sources and Production494
5. Biological Activities495
6. MCP Receptors498
7. Signal Transduction Pathways499
8. Murine MCPs500
9. MCPs in Disease501
10. Acknowledgments502
11. References502
Chapter 33. GRO/MGSA507
1. Introduction507
2. The Cytokine Gene508
3. The Protein511
4. Cellular Sources of GRO mRNAs and Proteins513
5. Functions of GRO Proteins516
6. GRO Receptors517
7. Signal Transduction by GRO518
8. Animal Models for the Study of GRO Function518
9. Acknowledgments519
10. References519
Summary Tables525
Glossary547
Key to Illustrations557
Index563

Book details

Vendor Elsevier S & T
SKU 9780124983403
ISBN-13 9780080530215
Author Mire-Sluis, Anthony R.; Thorpe, Robin
Category Medical
Subject Immunology

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This book provides comprehensive coverage of the cytokines from a pharmacological approach. The chapters are presented in a consistent format allowing easy cross-reference, with sample diagrams and a summary table of essential facts for each chapter at the end of the book.
Cytokines is unique in stressing cytokine biology and the application of research data to provide disease therapy. With 33 detailed and up-to-date chapters about individual cytokines, this comprehensive reference will provide both clinicians and researchers in immunology and pharmacology with invaluable information.

Key Features
* Genetic information and sequences
* Protein structure
* Cell sources and production
* Biological activity
* Cytokine receptor structure and signal transduction
* Discussion of the role of cytokines in disease and the potential for therapy
* Summary table of essential facts
* Comprehensive bibliography

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