Development of Auditory and Vestibular Systems-3: Molecular Development of the Inner Ear: Molecular Development of the Inner Ear
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Table of contents
- Copyright Pageiv
- Contentsv
- Contributorsxiii
- Forewordxv
- Introductionxvii
- Chapter 1. Molecular Conservation and Novelties in Vertebrate Ear Development1
- I. Introduction2
- II. Overview of Ideas Related to Ear Evolution4
- III. Making the Ear: Implementing and Expanding Genes for Ear Morphogenesis6
- IV. Evolution of the Ear: Molecular Origin of Mechanosensory Cells Predates Formation of the Ear11
- V. Developmental Molecular Biology of Hair Cell and Sensory Neuron Formation13
- VI. Evolution of Sensory Neurons: Heterochronic Alteration of HLH Gene Regulation22
- VII. Guidance of Afferent Fibers: The Role of Hair Cells and Other Mechanisms Revisited23
- VIII. Survival of Afferents: Evolving a Novel Mechanism and Expanding it to Fit the Increasing Compl29
- IX. Splitting Hair Cell and Neuron Populations: Coevolving Sensory Epithelia and Their Innervation33
- X. Summary and Conclusions: Evolving Developmental Mechanisms34
- Acknowledgments35
- References35
- Chapter 2. Use of Mouse Genetics for Studying Inner Ear Development45
- I. Introduction: The Genetic Revolution46
- II. Early Morphogenesis of the Inner Ear50
- III. Development of the Neuroepithelium55
- IV. Concluding Remarks75
- References75
- Chapter 3. Formation of the Outer and Middle Ear, Molecular Mechanisms85
- I. Introduction85
- II. Basic Anatomical and Embryological Overview86
- III. Genetic Determinants of Outer and Middle Ear Development89
- IV. Concluding Remarks107
- References108
- Chapter 4. Molecular Basis of Inner Ear Induction115
- I. Introduction116
- II. Inner Ear Induction in Fish118
- III. Inner Ear Induction in Amphibians127
- IV. Inner Ear Induction in Birds128
- V. Inner Ear Induction in Mammals131
- VI. Perspectives on Inner Ear Induction135
- VII. Conclusions141
- Acknowledgments142
- References142
- Chapter 5. Molecular Basis of Otic Commitment and Morphogenesis: A Role for Homeodomain-Containing T151
- I. Introduction152
- II. Patterning of the Inner Ear Anlagen152
- III. Transcription Factors and Diffusible Signals: A Complex Network162
- IV. Patterning and Morphogenesis165
- V. Conclusions170
- Acknowledgments171
- References171
- Chapter 6. Growth Factors and Early Development of Otic Neurons: Interactions between Intrinsic and177
- I. Introduction178
- II. Early Development of Cochlear (Auditory) and Vestibular Neurons179
- III. Extrinsic Factors in Inner Ear Neurogenesis: Fibroblast Growth Factor, Nerve Growth Factor, and187
- IV. Conclusions197
- Acknowledgments197
- References197
- Chapter 7. Neurotrophic Factors during Inner Ear Development207
- I. Neurotrophic Factors208
- II. The Neurotrophin System208
- III. The Glial Cell Line–Derived Neurotrophic Factor Family217
- IV. Conclusions219
- Acknowledgment219
- References219
- Chapter 8. FGF Signaling in Ear Development and Innervation225
- I. Introduction225
- II. Fibroblast Growth Factor Signaling in Ear Development232
- III. Conclusions and Future Directions251
- Acknowledgments252
- References252
- Chapter 9. The Roles of Retinoic Acid during Inner Ear Development261
- I. Introduction262
- II. Metabolism of Retinoids and Their Receptors263
- III. Expression of Retinoic Acid Metabolic Enzymes and Receptors in the Developing Inner Ear265
- IV. Is Retinoic Acid Involved in Otic Placode Induction?269
- V. Retinoids as Morphogens during Early Embryogenesis271
- VI. Retinoic Acid and Patterning Genes during Inner Ear Development278
- VII. Retinoic Acid and Hair Cell Differentiation280
- VIII. Concluding Remarks282
- Acknowledgment283
- References283
- Chapter 10. Hair Cell Development in Higher Vertebrates293
- I. Morphogenesis of the Mammalian Inner Ear294
- II. Control of Hair Cell Differentiation by Specific Genes294
- III. Production and Regeneration of New Hair Cells in Mature Inner Ears310
- IV. Conclusion312
- Acknowledgments315
- References315
- Chapter 11. Cell Adhesion Molecules during Inner Ear and Hair Cell Development, Including Notch and321
- I. Introduction322
- II. Adhesion Molecules323
- III. Adhesion Molecules and Development of the Inner Ear330
- IV. Summary345
- Acknowledgments346
- References346
- Chapter 12. Genes Controlling the Development of the Zebrafish Inner Ear and Hair Cells357
- I. Introduction358
- II. General Course of Zebrafish Otic Development359
- III. Otic Induction359
- IV. Patterning of the Placode and Early Vesicle367
- V. Development of Sensory Epithelia373
- VI. Auditory and Vestibular Function378
- VII. Conclusions and Prospects380
- References381
- Chapter 13. Functional Development of Hair Cells389
- I. Introduction390
- II. Maturation of Function390
- III. Development of Mechanoelectrical Transduction395
- IV. Developmental Acquisition of Basolateral Ion Channels406
- V. Outer Hair Cell Electromotility425
- VI. Interactions between Developing Hair Cells and Innervating Nerve Fibers427
- VII. Summary and Concluding Remarks433
- Acknowledgments434
- References434
- Chapter 14. The Cell Cycle and the Development and Regeneration of Hair Cells449
- I. Introduction449
- II. The Cell Cycle and the Regulation of Cell Proliferation450
- III. Hair Cell Development and Regeneration453
- IV. Cell Cycle Events during Hair Cell Development455
- V. The Cell Cycle during Hair Cell Regeneration459
- VI. Conclusions462
- Acknowledgments462
- References463
- Index467
- Contents of Previous Volumes483
- Color Plate SectionPlate1
Thanks to advances in genetics and genomics, research on inner ear development has flourished. Better approaches and experimental models have shed light on the function of a variety of vertebrate genes and their related proteins. This latest volume of Current Topics in Developmental Biology delves into this new research to show how the discovery of more genes involved in the development of the inner ear leads to the generation of new models that examine a wealth of issues -- from the origins of human deafness to the roles of genes during inner ear induction, development and differentiation. The wide variety of experimental approaches will help readers to understand the broad range of issues related to inner ear morphogenesis and other concepts from complementary areas of investigation. This state-of-the-art overview will be essential reading for researchers, clinicians and students alike.
* Scores of high-quality, full- color figures
* Detailed schemes on the structure and timing of ear development
* Current Topics in Developmental Biology is the longest-running forum for contemporary issues in developmental biology
* Scores of high-quality, full- color figures
* Detailed schemes on the structure and timing of ear development
* Current Topics in Developmental Biology is the longest-running forum for contemporary issues in developmental biology