Elsevier S & T

Developmental Vascular Biology

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Table of contents
  • Contentsv
  • Contributorsxi
  • Prefacexiii
  • Chapter 1. Blood Vessel Signals During Development and Beyond1
  • I. Introduction2
  • II. Vascular Development2
  • III. Vascular Cell–Cell Interactions3
  • IV. Cell Biology of ECs4
  • V. Heterogeneity of ECs8
  • VI. EC Interactions During Development9
  • VII. EC Interactions in Adult Tissues21
  • VIII. Evidence Against a Requirement for Endothelial Signals26
  • IX. Conclusions and Perspectives27
  • References29
  • Chapter 2. HIFs, Hypoxia, and Vascular Development37
  • I. Introduction37
  • II. Oxygen-Regulated Gene Expression38
  • III. HIF in Developmental O2 Homeostasis42
  • IV. HIF and Disease44
  • V. Conclusion47
  • References47
  • Chapter 3. Blood Vessel Patterning at the Embryonic Midline55
  • I. Introduction56
  • II. Vascular Development and Patterning56
  • III. Signaling Pathways Implicated in Vascular Patterning61
  • IV. Axial Structures Implicated in Vascular Patterning67
  • V. Conclusions and Future Directions75
  • References77
  • Chapter 4. Wiring the Vascular Circuitry: From Growth Factors to Guidance Cues87
  • I. Introduction87
  • II. Basic Signaling Pathways Required for Forming Blood Vessels88
  • III. The Formation of Arterial and Venous Networks90
  • IV. Effects of Local Cues on Arterial–Venous Identity95
  • V. Genetic Evidence for Vascular Guidance96
  • VI. Vascular Endothelial Growth Factors Are Attractive Guidance Cues98
  • VII. Guidance as a Balance of Attractive and Repulsive Cues100
  • VIII. Neural Guidance Pathways100
  • IX. Neural and Vascular Guidance Mechanisms Share Common Signaling Pathways104
  • X. Neuro-Vascular Development as Interdependent Processes108
  • XI. Independent Versus Interdependent Guidance of Vessels and Nerves112
  • XII. Future Directions in Vascular Guidance113
  • XIII. Summary113
  • References114
  • Chapter 5. Vascular Endothelial Growth Factor and Its Receptors in Embryonic Zebrafish Blood Vessel127
  • I. Introduction128
  • II. Vascular Growth Factors128
  • III. Blood Vessel Development129
  • IV. Advantages of the Zebrafish Model for Vascular Research130
  • V. Methods for Analyzing the Zebrafish Vasculature132
  • VI. Vascular Endothelial Growth Factor136
  • VII. VEGF Receptors138
  • VIII. Neuropilins139
  • IX. Semaphorins142
  • X. Future Perspectives143
  • References144
  • Chapter 6. Vascular Extracellular Matrix and Aortic Development153
  • I. Introduction154
  • II. Vessel Wall Formation and Structure155
  • III. The Vascular Extracellular Matrix156
  • IV. Collagens158
  • V. The Elastic Fiber162
  • VI. Fibulins166
  • VII. EMILIN/Multimerin Family168
  • VIII. Fibronectin169
  • IX. The Basement Membrane169
  • X. Proteoglycans172
  • XI. Matricellular Proteins175
  • XII. Correlation of Matrix Gene Expression Profile with Cytoskeletal Markers179
  • XIII. Conclusions180
  • References180
  • Chapter 7. Genetics in Zebrafish, Mice, and Humans to Dissect Congenital Heart Disease: Insights in189
  • I. Conserved Body Plan Architecture in Vertebrates190
  • II. Vascular Malformations194
  • III. Genetic Causes of CHDs and Vascular Anomalies195
  • IV. The Use of Animal Models198
  • V. Role of VEGF in Cardiovascular Development201
  • VI. Expression Patterns of VEGF in Mice Reveal Other Distinct Biological Functions203
  • VII. The Role of VEGF During Heart Septation204
  • VIII. VEGF: a Connector Between the Developing Vascular and Neuronal System205
  • IX. A Role for VEGF in Arterial EC Specification207
  • X. Normal Ontogenesis but Abnormal Remodeling of PAAs in Mice Lacking VEGF164207
  • XI. Association of VEGF Gene Variations with Cardiovascular Defects in DGS214
  • XII. Conclusion215
  • References215
  • Chapter 8. Development of Coronary Vessels225
  • I. Introduction225
  • II. Formation of the Proepicardium226
  • III. Formation of the Epicardium228
  • IV. Vasculogenesis in the Subepicardium231
  • V. Role of Growth Factors in Coronary Vasculogenesis233
  • VI. Epicardial to Mesenchymal Transformation (EMT)234
  • VII. Epicardial EMT Leads to Changes in Gene Expression237
  • VIII. Bidirectional Epicardial-Myocardial Signaling239
  • IX. Establishment of a Coronary Circulation: Making Connections to the Aorta241
  • X. Maturation of Coronary Vessels and Formation of a Tunica Media243
  • XI. Development of the Coronary Lymphatic Vessels246
  • XII. Coronary Vessel Anomalies247
  • XIII. Coronary Development and Disease249
  • References250
  • Chapter 9. Identifying Early Vascular Genes Through Gene Trapping in Mouse Embryonic Stem Cells261
  • I. Introduction261
  • II. Gene Discovery Through Mutagenesis Screens: Chemical Mutagenesis Versus Gene Trap Mutagenesis262
  • III. Entrapment Vectors263
  • IV. Gene Trap Screens266
  • V. ES Cell In Vitro Differentiation as a Model System to Identify Trapped Genes Expressed in Vascula269
  • VI. Designs of Cardiovascular Entrapment Screens272
  • VII. Conclusions and Future Directions276
  • References277
  • Index283
  • Contents of Previous Volumes295
Book details
  • Vendor Elsevier S & T
  • SKU 9780121531621
  • ISBN-13 9780080494357

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Current Topics in Developmental Biology provides a comprehensive survey of the major topics in the field of developmental biology. The volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology.

This volume contains ten important contributions from leading minds in developmental biology.

* Series Editor Gerald Schatten is one of the leading minds in reproductive and developmental science
* Presents major contemporary issues and astonishing discoveries at the forefront of modern developmental biology, stem cells and cloning, and regenerative medicine
* The longest-running forum for current issues in developmental biology with over 30 years of coverage