Digestive Involvement in Systemic Autoimmune Diseases
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Table of contents
- Cover
- Dedicationv
- Forewordvii
- List of Contributorsix
- Contentsxiii
- Part I: Introduction1
- Chapter 1. Digestive System and Autoimmunity3
- 1. The digestive system and gut-associated immunity3
- 2. Self-tolerance and autoimmunity6
- 3. Tolerance mechanisms for autoreactive B cells in the bone marrow6
- 4. Tolerance mechanisms for autoreactive T cells in the thymus7
- 5. Clonal anergy and tuning7
- 6. Extrinsic controls of self-reactive lymphocytes8
- 7. Limitation of costimuli8
- 8. Regulation of self-reactive lymphocytes in follicles9
- 9. Tolerance at the effector phase9
- 10. Conclusions9
- References10
- Chapter 2. Imaging Techniques in Digestive Diseases15
- 1. Introduction15
- 2. Imaging modalities15
- 3. Future prospects26
- References26
- Part II: Systemic Autoimmune Diseases29
- Chapter 3. Systemic Lupus Erythematosus31
- 1. Introduction31
- 2. General symptoms31
- 3. Oral cavity, oesophagus, and gastric abnormalities31
- 4. Main gastrointestinal syndromes32
- 5. Lupus-associated pancreatitis37
- References37
- Chapter 4. Antiphospholipid Syndrome39
- 1. Introduction39
- 2. Digestive involvement in APS40
- 3. Gastrointestinal involvement40
- 4. Hepatic involvement42
- 5. Splenic involvement45
- 6. Pancreatic involvement46
- References46
- Chapter 5. Gastrointestinal Involvement in Systemic Sclerosis51
- 1. Pathogenesis of GIT dysmotility51
- 2. Esophagus52
- 3. Stomach55
- 4. Small bowel56
- 5. Colon and anorectal disorders58
- 6. Patient-reported outcome measure59
- 7. Conclusion59
- Acknowledgment60
- References60
- Chapter 6. Inflammatory Myopathies63
- 1. Introduction63
- 2. Oral cavity64
- 3. Dysphagia65
- 4. Bowel66
- 5. Liver66
- 6. Juvenile dermatomyositis67
- 7. Summary67
- References67
- Chapter 7. Digestive Involvement in Primary Sjögren’s Syndrome71
- 1. Esophageal involvement72
- 2. Gastric involvement72
- 3. Intestinal involvement73
- 4. Pancreatic involvement74
- 5. Liver involvement75
- References78
- Chapter 8. Gastrointestinal Involvement in Systemic Vasculitis83
- 1. Introduction83
- 2. Large-vessel vasculitis84
- 3. Takayasu’s arteritis84
- 4. Giant cell arteritis85
- 5. Chronic periaortitis (Index case)87
- 6. Medium-sized vessel vasculitis89
- 7. Small-sized vessels vasculitis90
- 8. Mixed cryoglobulinemia, HCV infection and gastrointestinal involvement92
- References96
- Chapter 9. Mixed Connective Tissue Disease101
- 1. Are gastrointestinal features a common manifestation of mixed connective tissue disease?101
- 2. Oral manifestations102
- 3. Esophageal dysfunction103
- 4. Bowel manifestations104
- 5. Other conditions104
- 6. Therapeutic considerations105
- 7. Discussion105
- 8. Summary106
- References106
- Chapter 10. Gastrointestinal Manifestations of Rheumatoid Arthritis109
- 1. Manifestations directly due to rheumatoid arthritis109
- 2. Gastrointestinal disease resulting from rheumatoid arthritis therapeutics111
- 3. Mimics of gastrointestinal disease in rheumatoid arthritis112
- 4. Summary and conclusions114
- References114
- Part III: Autoimmune Liver Diseases119
- Chapter 11. Immunopathogenesis of Autoimmune Liver Damage121
- 1. Disturbances in antigen recognition122
- 2. Deficiencies in regulatory networks124
- 3. Genetic and gender predispositions128
- 4. Summary134
- References134
- Chapter 12. Primary Biliary Cirrhosis141
- 1. Introduction141
- 2. Epidemiological highlights141
- 3. Pathophysiological insights142
- 4. Clinical presentations145
- 5. Natural history and prognostic considerations146
- 6. Treatment considerations147
- 7. Conclusion148
- References148
- Chapter 13. Autoimmune Hepatitis153
- 1. Definition153
- 2. History and epidemiology153
- 3. Clinical features154
- 4. Diagnosis and laboratory findings154
- 5. Pathophysiology158
- 6. Management and prognosis162
- 7. Recurrence of AIH after transplant163
- 8. De novo AIH after transplant163
- 9. Conclusion164
- References164
- Chapter 14. Primary Sclerosing Cholangitis169
- 1. Aetiology169
- 2. Diagnosis175
- 3. Small duct PSC175
- 4. Autoimmune pancreatitis (AIP)175
- 5. Prognosis175
- 6. Conclusion184
- References184
- Part IV: Autoimmunity and Viral Hepatitis189
- Chapter 15. Systemic and Autoimmune Manifestations of Hepatitis B Virus Infection191
- 1. Introduction191
- 2. Hepatitis B virus infection192
- 3. Extra-hepatic manifestations of HBV infection194
- References205
- Chapter 16. Extrahepatic Manifestations in Patients with Chronic Hepatitis C Virus Infection209
- 1. Introduction209
- 2. Autoantibodies and HCV209
- 3. Organ-specific autoimmune diseases and HCV210
- 4. Systemic autoimmune diseases and HCV211
- 5. Hematological diseases and HCV218
- 6. Therapeutic management of extrahepatic features220
- References222
- Part V: Other Conditions229
- Chapter 17. Autoantibodies in Gastrointestinal Autoimmune Diseases231
- 1. Antibodies in inflammatory bowel diseases231
- 2. Antibodies in celiac disease234
- 3. Antibodies in autoimmune liver diseases236
- References240
- Chapter 18. Gastrointestinal Complications of Anti-Rheumatic Drugs243
- 1. Introduction243
- 2. The clinical setting243
- 3. Gastrointestinal reactions in autoimmune arthropathies246
- 4. Coxibs versus non-selective NSAIDs251
- 5. Potential for impact of arthritic disease254
- 6. GI symptomatic adverse drug reactions255
- 7. Enter the second-generation coxibs255
- 8. Strategies to minimise or eliminate gastrointestinal complications256
- 9. Discussion and conclusions266
- References266
- Subject Index277
- Colour Plate Section297
The Digestive System in Systemic Autoimmune Diseases represents the state-of-the-art in the field of digestive disorders in the most common systemic autoimmune diseases.
The volume consists of an introductory chapter on imaging techniques in digestive diseases, followed by eight chapters on digestive manifestations in specific systemic autoimmune diseases. The final five chapters deal with digestive diseases with an autoimmune pathogenesis and systemic manifestations.
International in scope, the table of contents reads like a Who's who in clinical research on systemic autoimmune diseases. More than 20 contributors from the European Union, the United States, Mexico and South Africa share their knowledge in this detailed volume.
*One book of leading international clinical and scientific experts on autoimmune and digestive diseases
*A practical guide to the identification, diagnosis and treatment of digestive involvement in patients with autoimmune diseases that will be useful for all medical specialties
*Several diseases and conditions not included in other text books are included, some of which are of recent emergence
*Each chapter is designed to serve as a “Guide to Clinical Practice for each disease
The volume consists of an introductory chapter on imaging techniques in digestive diseases, followed by eight chapters on digestive manifestations in specific systemic autoimmune diseases. The final five chapters deal with digestive diseases with an autoimmune pathogenesis and systemic manifestations.
International in scope, the table of contents reads like a Who's who in clinical research on systemic autoimmune diseases. More than 20 contributors from the European Union, the United States, Mexico and South Africa share their knowledge in this detailed volume.
*One book of leading international clinical and scientific experts on autoimmune and digestive diseases
*A practical guide to the identification, diagnosis and treatment of digestive involvement in patients with autoimmune diseases that will be useful for all medical specialties
*Several diseases and conditions not included in other text books are included, some of which are of recent emergence
*Each chapter is designed to serve as a “Guide to Clinical Practice for each disease