Elsevier S & T

DNA Repair and Replication

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Table of contents
  • DNA Repair and Replicationiii
  • Copyright Pageiv
  • CONTENTSv
  • PREFACEix
  • Chapter 1. Base Excision Repair1
  • I. Introduction1
  • II. Types of Damage Repaired by BER5
  • III. DNA Glycosylases7
  • IV. Downstream BER Enzymes18
  • V. Mammalian BER23
  • VI. Roles of BER Enzymes in Other Processes27
  • References28
  • Chapter 2. Nucleotide Excision Repair in E. Coli and Man43
  • I. Introduction43
  • II. Damage Recognition45
  • III. Mechanism of Excision Repair48
  • IV. Transcription-Coupled Repair56
  • V. Repair of Chromatin59
  • VI. Conclusion63
  • References65
  • Chapter 3. Photolyase and Cryptochrome Blue-Light Photoreceptors73
  • I. Introduction73
  • II. Phylogenetics74
  • III. Structure of Photolyase77
  • IV. Reaction Mechanism of Photolyase79
  • V. (6–4) Photolyase86
  • VI. Cryptochrome90
  • VII. Conclusion96
  • References96
  • Chapter 4. Coordination of Repair, Checkpoint, and Cell Death Responses to DNA Damage101
  • I. Introduction101
  • II. Overview of Biological Responses to DNA Damage104
  • III. Molecular Components for the Initiation of DNA Damage Responses109
  • IV. Apoptotic Effectors in DNA Damage Response115
  • V. DNA Repair Proteins in Damage Signaling120
  • VI. Alternative Models for the Temporal Coordination of DNA Damage Responses123
  • VII. Future Prospects127
  • References128
  • Chapter 5. Functions of DNA Polymerases137
  • I. DNA Polymerase Families137
  • II. Structures and Compositions of DNA Polymerases139
  • III. Functions of DNA Polymerases141
  • IV. Polymerases for DNA Repair141
  • V. Polymerases for Replicating Undamaged DNA150
  • VI. Polymerases for Sister Chromatid Cohesion151
  • VII. Mitochondrial DNA Replication.152
  • VIII. Polymerases for Replicating Damaged DNA.152
  • IX. Polymerases and Cell-Cycle Checkpoints155
  • X. Polymerases for Replication Restart and Homologous Recombination155
  • XI. Polymerases for DNA Mismatch Repair156
  • XII. Polymerases in the Development of the Immune System156
  • XIII. Biological Consequences of Polymerase Dysfunction157
  • XIV. Closing Comments158
  • References159
  • Chapter 6. Cellular Functions of DNA Polymerase and Rev1 Protein167
  • I. Introduction167
  • II. Enzymological Studies With Polζ and Rev1p172
  • III. Genetic Analysis178
  • IV. Processes Other than General Translesion Replication that Employ Pol and Rev1p182
  • V. Regulation of Polζ and Rev1p and Interactions with other Proteins186
  • VI. Conclusions and Speculations190
  • References195
  • Chapter 7. DNA Polymerasesη and ι205
  • I. Historical Perspective205
  • II. Identification of RAD30 and its Orthologs206
  • III. Biochemical Properties of Polη and Polι207
  • IV. Translesion Synthesis by Polη and Polι210
  • V. Structure of the Catalytic Core of S. cerevisiae Polη212
  • VI. Regulation and Localization of Polη and Polι215
  • VII. Mutations in Polcη in XP Variants217
  • VIII. Polsη and ι and the Polymerase Switch: Interactions with PCNA and Rev1219
  • IX. Protection from Cellular Effects of DNA Damage220
  • X. Roles of Polη and Polι in Somatic Hypermutation221
  • References222
  • Chapter 8. Properties and Functions of Escherichia Coli : Pol IV and Pol V229
  • I. DNA Pol IV, the dinB Gene Product230
  • II. DNA Polymerase V, the umuDC Gene Product248
  • References257
  • Chapter 9. Mammalian Pol κ: Regulation of Its Expression and Lesion Substrates265
  • I. Structures of the Genes and Proteins265
  • II. Enzymatic Properties of Polκ271
  • III. Possible Mechanisms of TLS by Polκ In Vivo274
  • References275
  • Chapter 10. DNA Postreplication Repair Modulated by Ubiquitination and Sumoylation279
  • I. Introduction279
  • II. DNA Postreplication Repair Prokaryotes280
  • III. DNA Postreplication Repair in Eukaryotes281
  • IV. Ubiquitination283
  • V. Protein Conjugation in PRR286
  • VI. Postreplication Repair via Covalent Modifications of PCNA292
  • VII. Functional Conservation of Eukaryotic Postreplication Repair295
  • VIII. Future Directions297
  • IX. Conclusions300
  • References301
  • Chapter 11. Somatic Hypermutation: A Mutational Panacea307
  • I. Generation of Antibody Diversity307
  • II. Somatic Hypermutation313
  • III. Apobec Protein Family323
  • IV. Biochemical Perspective326
  • References327
  • Author Index337
  • Subject Index369
Book details
  • Vendor Elsevier S & T
  • SKU 9780120342693
  • ISBN-13 9780080522425

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DNA Repair and Replication contains an up-to-date review of general principles of DNA replication and an overview of the multiple pathways involved in DNA repair. Specific DNA repair pathways, including base-excision repair, light-dependent direct reversal of UV-damage, nucleotide-excision repair, transcription-coupled repair, double-strand break repair, and mismatch repair, are each discussed in separate chapters.

Selected Contents:
-Base Excision Repair
-Eukaryotic DNA Mismatch Repair
-Double Strand Break Repair
-Functions of DNA Polymerases
-Somatic Hypermutation: A Mutational Panacea