Energetics of Biological Macromolecules, Part C
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Table of contents
- Table of Contentsvii
- Contributors to Volumexi
- Prefacexv
- Volumes in Seriesxvii
- Chapter 1. Quantitative Dissection of Transcriptional Control System: N-Dependent Antitermination Co1
- Chapter 2. Problems and Prospects in Microcalorimetry of Biological Macromolecules31
- Chapter 3. Probing Stability of Helical Transmembrane Proteins63
- Chapter 4. Energetics of Vinca Alkaloid Interactions with Tubulin77
- Chapter 5. Kinetics and Thermodynamics of Conformational Equilibria in Native Proteins by Hydrogen E104
- Chapter 6. Mathematical Modeling of Cooperative Interactions in Hemoglobin124
- Chapter 7. Deriving Complex Ligand-Binding Formulas155
- Chapter 8. Calculation of Entropy Changes in Biological Processes. Folding, Binding, and Oligomeriza167
- Chapter 9. Evaluating Energetics of Erythropoietin Ligand Binding to Homodimerized Receptor Extracel177
- Chapter 10. Measurement of Protein Interaction Bioenergetics. Application to Structural Variants of207
- Chapter 11. Analysis of Interaction of Regulatory Protein TyrR with DNA231
- Chapter 12. Proteolytic Footprinting Titrations for Estimating Ligand-Binding Constants and Detectin254
- Chapter 13. Analysis of Reversibly Interacting Macromolecular Systems by Time Derivative Sedimentati302
- Chapter 14. Kinetic, Equilibrium, and Thermodynamic Analysis of Macromolecular Interactions with BIA325
- Chapter 15. Structure–Function Relationships in Two-Component Phospholipid Bilayers: Monte Carlo S340
- Chapter 16. Parsing Free Energies of Drug–DNA Interactions373
- Chapter 17. Direct Measurement of Sodium Ion Release from DNA on Binding of Cationic Ligands406
- Chapter 18. Enthalpy–Entropy Compensations in Nucleic Acids. Contribution of Electrostriction and419
- Chapter 19. Time-Resolved Fluorescence Methods for Analysis of DNA–Protein Interactions442
- Chapter 20. Use of Fluorescence Spectroscopy as Thermodynamics Tool459
- Chapter 21. Microsecond Dynamics of Biological Macromolecules473
- Author Index511
- Subject Index531
- Chapter 22. Errata545
Volume 323 of Methods in Enzymology is dedicated to the energetics of biological macromolecules. Understanding the molecular mechanisms underlying a biological process requires detailed knowledge of the structural relationships within the system and an equally detailed understanding of the energetic driving forces that control the structural interactions. This volume presents modern thermodynamic techniques currently being utilized to study the energetic driving forces in biological systems. It will be a useful reference source and textbook for scientists and students whose goal is to understand the energetic relationships between macromoleculer structures and biological functions.
This volume supplements Volumes 259 and Volume 295 of Methods in Enzymology.
Key Features
* Probing Stability of Helical Transmembrane Proteins
* Energetics of Vinca Alkaloid Interactions with Tubulin
* Deriving Complex Ligand Binding Formulas
* Mathematical Modeling of Cooperative Interactions in Hemoglobin
* Analysis of Interactions of Regulatory Protein TyrR with DNA
* Parsing Free Energy of Drug-DNA Interactions
* Use of Fluorescence as Thermodynamics Tool
This volume supplements Volumes 259 and Volume 295 of Methods in Enzymology.
Key Features
* Probing Stability of Helical Transmembrane Proteins
* Energetics of Vinca Alkaloid Interactions with Tubulin
* Deriving Complex Ligand Binding Formulas
* Mathematical Modeling of Cooperative Interactions in Hemoglobin
* Analysis of Interactions of Regulatory Protein TyrR with DNA
* Parsing Free Energy of Drug-DNA Interactions
* Use of Fluorescence as Thermodynamics Tool