Elsevier S & T

Energy Metabolism and Lifespan Determination

Mattson, M.P.

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Table of contents
  • Cover
  • Energy Metabolism and Lifespan Determinationi
  • Copyright Pageiv
  • Table of Contentv
  • Prefacevii
  • Chapter 1. The Search for Energy: A Driving Force in Evolution and Aging1
  • Chapter 2. Insulin Signaling, Glucose Metabolism Oxidative Stress, and Aging13
  • Chapter 3. Oxidative Phosphorylation, Mitochondrial Proton Cycling, Free-radical Production and Agin35
  • Chapter 4. Protein Turnover, Energy Metabolism, Aging, and Caloric Restriction69
  • Chapter 5. Cellular and Molecular Mechanisms Whereby Dietary Restriction Extends Healthspan: A Benef87
  • Chapter 6. Mitochondrial Oxidative Stress and Caloric Restriction105
  • Chapter 7. Understanding the Aging Fly Through Physiological Genetics123
  • Chapter 8. Metabolism and Life span Determination in C. elegans143
  • Chapter 9. Electron Transport and Life span in C. elegans177
  • Chapter 10. Cellular Glucose Sensing, Energy Metabolism, and Aging in Saccharomyces cerevisiae197
  • List of Contributors215
Book details
  • Vendor Elsevier S & T
  • SKU 9780444514929
  • ISBN-13 9780080494760
  • Author Mattson, M.P.
  • Category Medical
  • Subject Geriatrics

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Experts in the fields of energy metabolism, aging and oxidative stress provide an integrated view of how mechanisms involved in regulating energy metabolism are linked to fundamental processes of aging including cellular stress resistance and free radical production.



During evolution signal transduction pathways and organ systems have been optimised for the efficient seeking, ingestion, storing and using of energy. These signalling pathways play prominent roles in lifespan determination with insulin and related signalling pathways being prime examples. The authors consider how lifespan and healthspan can be extended through knowledge of energy metabolism with the experimental model of dietary restriction being one example. The information in this volume of ACAG will foster novel approaches and experiments for further understanding the roles of energy metabolism in aging and disease.