Engineering Biosensors: Kinetics and Design Applications
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Table of contents
- Cover
- Contentsvii
- Prefacexi
- Chapter 1. Introduction1
- 1.1 Background, Definition, and the Need for Biosensors1
- 1.2 Assay Formats10
- 1.3 Difficulties with Biosensor Applications12
- 1.4 Newer Applications for Biosensors13
- 1.5 Commercially Avialable Biosoensors17
- 1.6 Biomedical Applications17
- 1.7 Overview19
- Chapter 2. Influence of Diffusional Limitations and Reaction Order on Antigen–Antibody Binding Kin23
- 2.1 Introduction23
- 2.2 Theory24
- Chapter 3. Influence of Diffusional Limitations and Lateral Interactions on Antigen–Antibody Bindi45
- 3.1 Introduction45
- 3.2 Theory46
- 3.3 Conclusions63
- Chapter 4. Fractal Reaction Kinetics67
- 4.1 Introduction67
- 4.2 Fractal Kinetics69
- Chapter 5. Influence of Different Parameters on Fractal Dimension Values During the Binding Phase83
- 5.1 Introduction83
- 5.2 Theory85
- 5.3 Results89
- 5.4 Summary and Conclusions122
- Chapter 6. Fractal Dimension and the Binding Rate Coefficient127
- 6.1 Introduction127
- 6.2 Theory130
- 6.3 Results133
- 6.4 Conclusions183
- Chapter 7. Fractal Dimension and the Dissociation Rate Coefficient187
- 7.1 Introduction187
- 7.2 Theory190
- 7.3 Results195
- 7.4 Conclusions216
- Chapter 8. Influence of Nonspecific Binding on the Rate and Amount of Specific Binding: A classical221
- 8.1 Introduction221
- 8.2 Theory230
- Chapter 9. Influence of Nonspecific Binding on the Rate and Amount of Specific Binding: A Fractal A253
- 9.1 Introduction253
- 9.2 Theory255
- 9.3 Results257
- 9.4 Other Examples of Interest265
- 9.5 Conclusions269
- Chapter 10. Fractal Dimension and Hybridization273
- 10.1 Introduction273
- 10.2 Theory275
- 10.3 Results276
- 10.4 Conclusions307
- Chapter 11. Fractal Dimension and Analyte-Receptor Binding in Cells311
- 11.1 Introduction311
- 11.2 Theory313
- 11.3 Results315
- 11.4 Conclusions341
- Chapter 12. Surface Plasmon Resonance Biosensors345
- 12.1 Introduction345
- 12.2 Theory347
- 12.3 Results349
- 12.4 Conclusions379
- Chapter 13. Economics and Market for Biosensors385
- 13.1 Introduction385
- 13.2 Market Size and Economics386
- 13.3 Development Cost of a Biosensor393
- 13.4 Cost Reduction Methods395
- Index399
Biosensors are becoming increasingly important bioanalytical tools in the pharmaceutical, biotechnology, food, and other consumer oriented industries. The technology, though well developed in Europe, is slowly developing and has begun to generate interest in the United States only over the past couple of years. Research is now being directed toward the development of biosensors that are versatile, economical, and simple to use.
Engineering Biosensors is a comprehensive introduction to biosensors that includes numerous illustrations to further explain the main concepts and practical examples from existing literature. It describes what biosensors are, where they are used, and how their performance is affected by existing surface characteristics.
A better understanding of biosensors, as provided by this book, will greatly assist in the design of new as well as the improvement of existing biosensors. Readers are also provided with invaluable and hard-to-find data on the economics of the biosensor market to assist them in better understanding the market and where it is heading.
Engineering Biosensors is a comprehensive introduction to biosensors that includes numerous illustrations to further explain the main concepts and practical examples from existing literature. It describes what biosensors are, where they are used, and how their performance is affected by existing surface characteristics.
A better understanding of biosensors, as provided by this book, will greatly assist in the design of new as well as the improvement of existing biosensors. Readers are also provided with invaluable and hard-to-find data on the economics of the biosensor market to assist them in better understanding the market and where it is heading.