Enzyme Kinetics and Mechanisms, Part E, Energetics of Enzyme Catalysis
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Table of contents
- Table of Contentsv
- Contributors to Volume 308vii
- Prefaceix
- Volumes in Seriesxi
- Section I: Energetic Coupling in Enzymatic Reactions1
- Chapter 1. Energetics of Substrate Binding, Catalysis, and Product Release3
- Chapter 2. Energy Coupling Through Molecular Discrimination: Nicotinate Phosphoribosyltransferase28
- Chapter 3. On the Advantages of Imperfect Energetic Linkage48
- Chapter 4. Reaction Dynamics of G-Protein Catalyzed Hydrolysis of GTP as Viewed by X-Ray Crystallogr70
- Chapter 5. Energetics of Nucleotide Hydrolysis in Polymer Assembly/Disassembly: The Cases of Actin a93
- Chapter 6. Fundamental Mechanisms of Substrate Channeling111
- Section II: Intermediates and Complexes in Catalysis147
- Chapter 7. Intermediates and Energetics in Pyruvate Phosphate Dikinase149
- Chapter 8. Raman Spectroscopic Studies of the Structures, Energetics, and Bond Distortions of Substr176
- Chapter 9. Crystallographic Analysis of Solvent-Trapped Intermediates of Chymotrypsin201
- Section III: Detection and Properties of Low-Barrier Hydrogen Bonds217
- Chapter 10. Nuclear Magnetic Resonance Methods for the Detection and Study of Low-Barrier Hydrogen B219
- Chapter 11. Hydrogen Bonding in Enzymatic Catalysis: Analysis of Energetic Contributions246
- Chapter 12. Application of Marcus Rate Theory to Proton Transfer in Enzyme-Catalyzed Reactions276
- Section IV: Transition State Determination and Inhibitors299
- Chapter 13. Enzymatic Transition-State Analysis and Transition-State Analogues301
- Chapter 14. Determining Transition States from Kinetic Isotope Effects355
- Chapter 15. Computational Methods for Transition State and Inhibitor Recognition398
- Author Index427
- Subject Index447
- Color Plate SectionColor Plate-1
This volume supplements Volumes 63, 64, 87, and 249 of Methods in Enzymology. These volumes provide a basic source for the quantitative interpretation of enzyme rate data and the analysis of enzyme catalysis. Among the major topics covered are Engergetic Coupling in Enzymatic Reactions, Intermediates and Complexes in Catalysis, Detection and Properties of Low Barrier Hydrogen Bonds, Transition State Determination, and Inhibitors.
The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.
The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.