Eukaryotic Transcription Factors
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Table of contents
- Cover
- Contentsvii
- List of Tablesxiii
- About the authorxv
- Prefacexvii
- Preface to the third editionxx
- Preface to the second editionxxii
- Preface to the first editionxix
- Acknowledgementsxxv
- Chapter 1. DNA Sequences, Transcription Factors and Chromatin Structure1
- 1.1 The importance of transcription1
- 1.2 Chromatin structure and its remodelling2
- 1.3 DNA sequence elements7
- 1.4 Conclusions19
- Chapter 2. Methods for Studying Transcription Factors23
- 2.1 Introduction23
- 2.2 Methods for studying DNA–protein interactions23
- 2.3 Methods for purifying and/or cloning transcription factors34
- 2.4 Use of cloned genes41
- 2.5 Conclusions50
- Chapter 3. RNA Polymerases and the Basal Transcriptional Complex55
- 3.1 RNA polymerases55
- 3.2 The stable transcriptional complex57
- 3.3 RNA polymerase I58
- 3.4 RNA polymerase III60
- 3.5 RNA polymerase II63
- 3.6 TBP, the universal transcription factor?67
- 3.7 Conclusions73
- Chapter 4. Families of DNA Binding Transcription Factors77
- 4.1 Introduction77
- 4.2 The homeodomain78
- 4.3 The two cysteine two histidine zinc finger102
- 4.4 The multi-cysteine zinc finger107
- 4.5 The basic DNA binding domain117
- 4.6 Other DNA-binding motifs124
- 4.7 Conclusions125
- Chapter 5. Activation of Gene Expression by Transcription Factors135
- 5.1 Activation domains135
- 5.2 Nature of activation domains136
- 5.3 Interaction of activation domains with the basal transcriptional complex142
- 5.4 Interaction of activation domains with other regulatory proteins149
- 5.5 Other targets for transcriptional activators162
- 5.6 Conclusions174
- Chapter 6. Repression of Gene Expression by Transcription Factors183
- 6.1 Repression of transcription183
- 6.2 Indirect repression183
- 6.3 Direct repression191
- 6.4 Other targets for transcriptional repressors200
- 6.5 Conclusions205
- Chapter 7. Regulation of Transcription Factor Synthesis211
- 7.1 Transcription factor regulation211
- 7.2 Regulated synthesis of transcription factors211
- 7.3 Mechanisms regulating the synthesis of transcription factors229
- 7.4 Conclusions240
- Chapter 8. Regulation of Transcription Factor Activity245
- 8.1 Evidence for the regulated activity of transcription factors245
- 8.2 Regulation by protein–ligand binding247
- 8.3 Regulation by protein–protein interactions255
- 8.4 Regulation by protein modification265
- 8.5 Regulation by protein degradation and processing281
- 8.6 Role of regulated activity283
- 8.7 Conclusions285
- Chapter 9. Transcription Factors and Human Disease293
- 9.1 Diseases caused by transcription factor mutations293
- 9.2 Cancer297
- 9.3 Cellular oncogenes and cancer299
- 9.4 Anti-oncogenes and cancer314
- 9.5 Conclusions331
- Chapter 10. Conclusions and Future Prospects341
- Index345
- Color Plate Section361
Now in two-colour throughout, the fourth edition of Eukaryotic Transcription Factors has been completely rewritten and restructured to take into account the tremendous advances in our understanding of transcription factors and the mechanisms by which they act. Considerable emphasis has been given to the interaction between transcription factors and chromatin structure. Also included is an entirely new section on the mediator complex and expansion of the space devoted to co-activators and co-repressors.
This book is essential reading for all those who wish to understand the impact of molecular biology on medicine, whatever their speciality.
* Major families of eukaryotic transcription factors described
* Mechanisms of gene activation and repression analysed
* Structure-function relationships indicated
* Interaction between transcription factors and chromatin structure described
* Roles in inducible and cell type-specific gene expression
* Roles in development, differentiation and human diseases including cancer
* Methods of study in vitro and in vivo
This book is essential reading for all those who wish to understand the impact of molecular biology on medicine, whatever their speciality.
* Major families of eukaryotic transcription factors described
* Mechanisms of gene activation and repression analysed
* Structure-function relationships indicated
* Interaction between transcription factors and chromatin structure described
* Roles in inducible and cell type-specific gene expression
* Roles in development, differentiation and human diseases including cancer
* Methods of study in vitro and in vivo