From Molecules to Networks: An Introduction to Cellular and Molecular Neuroscience
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Table of contents
- Copyright Pageiv
- Full Contentsvii
- Contributorsxi
- Prefacexiii
- Chapter 1. Cellular Components of Nervous Tissue1
- The Neuron1
- The Neuroglia13
- The Cerebral Vasculature22
- Chapter 2. Subcellular Organization of the Nervous System: Organelles and Their Functions31
- Axons and Dendrites: Unique Structural Components of Neurons31
- Protein Synthesis in Nervous Tissue36
- The Cytoskeletons of Neurons and Glial Cells47
- Molecular Motors in the Nervous System55
- Building and Maintaining Nervous System Cells58
- Chapter 3. Brain Energy Metabolism67
- Energy Metabolism of the Brain as a Whole Organ67
- Tight Coupling of Neuronal Activity, Blood Flow, and Energy Metabolism70
- Energy-Producing and Energy-Consuming Processes in the Brain73
- Brain Energy Metabolism at the Cellular Level77
- Glutamate and Nitrogen Metabolism: A Coordinated Shuttle Between Astrocytes and Neurons84
- The Astrocyte–Neuron Metabolic Unit87
- Chapter 4. Electrotonic Properties of Axons and Dendrites91
- Spread of Steady-State Signals93
- Spread of Transient Signals98
- Electrotonic Properties Underlying Propagation in Axons100
- Electrotonic Spread in Dendrites102
- Dynamic Properties of Passive Electrotonic Structure106
- Relating Passive to Active Potentials111
- Chapter 5. Membrane Potential and Action Potential115
- The Membrane Potential116
- The Action Potential121
- Chapter 6. Molecular Properties of Ion Channels141
- Families of Ion Channels141
- Channel Gating144
- Ion Permeation149
- Ion Channel Distribution154
- Summary157
- Chapter 7. Dynamical Properties of Excitable Membranes161
- The Hodgkin–Huxley Model161
- A Geometric Analysis of Excitability179
- Chapter 8. Release of Neurotransmitters197
- Organization of the Chemical Synapse197
- Excitation–Secretion Coupling202
- The Molecular Mechanisms of the Nerve Terminal208
- Quantal Analysis221
- Short-Term Synaptic Plasticity235
- Chapter 9. Pharmacology and Biochemistry of Synaptic Transmission: Classic Transmitters245
- Diverse Modes of Neuronal Communication245
- Chemical Transmission246
- Classic Neurotransmitters250
- Summary276
- Chapter 10. Nonclassic Signaling in the Brain279
- Peptide Neurotransmitters279
- Neurotensin as an Example of Peptide Neurotransmitters285
- Unconventional Transmitters287
- Synaptic Transmitters in Perspective295
- Chapter 11. Neurotransmitter Receptors299
- Ionotropic Receptors299
- G Protein-Coupled Receptors319
- Chapter 12. Intracellular Signaling335
- Signaling Through G-Protein-Linked Receptors335
- Modulation of Neuronal Function by Protein Kinases and Phosphatases353
- Chapter 13. Regulation of Neuronal Gene Expression and Protein Synthesis371
- Intracellular Signaling Affects Nuclear Gene Expression371
- Role of cAMP and Ca2+ in the Activation Pathways of Transcription380
- Summary388
- Chapter 14. Mathematical Modeling and Analysis of Intracellular Signaling Pathways391
- Methods for Modelling Intracellular Signaling Pathways393
- General Issues in the Modeling of Biochemical Systems408
- Specific Modeling Methods411
- Summary426
- Chapter 15. Cell–Cell Communication: An Overview Emphasizing Gap Junctions431
- Chemical and Electrical Synapses Differ in Functional Characteristics435
- Biophysical and Pharmacological Properties of Gap Junctions in the Nervous System439
- Role of Gap Junctions in Functions of Nervous Tissue442
- Gap Junction-Related Neuropathologies448
- Chapter 16. Postsynaptic Potentials and Synaptic Integration459
- Ionotropic Receptors: Mediators of Fast Excitatory and Inhibitory Synaptic Potentials459
- Metabotropic Receptors: Mediators of Slow Synaptic Potentials472
- Integration of Synaptic Potentials475
- Chapter 17. Information Processing in Complex Dendrites479
- Strategies for Studying Complex Dendrites480
- Summary: The Dendritic Tree as a Complex Information Processing System495
- Chapter 18. Learning and Memory: Basic Mechanisms499
- Long-Term Synaptic Potentiation and Depression499
- Paradigms Have Been Developed To Study Associative and Nonassociative Learning529
- Invertebrate Studies: Key Insights From Aplysia Into Basic Mechanisms of Learning531
- Classical Conditioning in Vertebrates: Discrete Responses and Fear as Models of Associative Learning543
- How Does a Change in Synaptic Strength Store Complex Memory?560
- Summary562
- Index575
An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. This book provides the solid foundation of the morphological, biochemical, and biophysical properties of nerve cells that is needed by advanced undergraduates and graduate students, as well as researchers in need of a thorough reference.
* Highly referenced for readers to pursue topics of interest in greater detail
* Unique coverage of the application of mathematical modeling and simulation approaches not found in other textbooks
* Richly illustrated, four color presentation throughout
* Includes CD-ROM of all of the illustrations
* Highly referenced for readers to pursue topics of interest in greater detail
* Unique coverage of the application of mathematical modeling and simulation approaches not found in other textbooks
* Richly illustrated, four color presentation throughout
* Includes CD-ROM of all of the illustrations