From NEUROSCIENCE To NEUROLOGY: Neuroscience, Molecular Medicine, and the Therapeutic Transformation of Neurology
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Table of contents
- Cover
- Contentsv
- Prefacevii
- Contributorsix
- Part I: Clinical Rewards From Neuroscience, Molecular Medicine, and Translational Research1
- Chapter 1. Seeing the Brain So We Can Save It: The Evolution of Magnetic Resonance Imaging as a Clin3
- Chapter 2. Advances in the Acute Treatment and Secondary Prevention of Stroke21
- Chapter 3. Preserving Function in Acute Nervous System Injury35
- Chapter 4. Slowing the Progression of Multiple Sclerosis61
- Chapter 5. The Emergence of Neurosurgical Approaches to the Treatment of Epilepsy81
- Chapter 6. The Neurobiology of Migraine and Transformation of Headache Therapy107
- Chapter 7. Botulinum Toxins: Transformation of a Toxin into a Treatment125
- Chapter 8. Prospects for Slowing the Progression of Parkinson’s Disease141
- Chapter 9. Current Neurosurgical Treatments for Parkinson’s Disease: Where Did They Come From?159
- Chapter 10. Treatable Peripheral Neuropathies: Plasma Exchange, Intravenous Immunoglobulin, and Othe175
- Chapter 11. Molecular Pharmacology and the Treatment of Tourette’s Syndrome and Attention Deficit-183
- Chapter 12. Neuroscience, Molecular Medicine, and New Approaches to the Treatment of Depression and193
- Part II: Moving Toward The Clinic: Evolving Themes and Technologies215
- Chapter 13. Genomics, Proteomics, and Neurology217
- Chapter 14. Neuroprotection: Where Are We Going?237
- Chapter 15. Prospects for Gene Therapy for Central Nervous System Disease267
- Chapter 16. Therapeutics Development for Hereditary Neurological Diseases285
- Chapter 17. Inherited Channelopathies of the CNS: Lessons for Clinical Neurology293
- Chapter 18. Inherited Channelopathies of Muscle: Implications for Therapy303
- Chapter 19. Transcriptional Channelopathies of the Nervous System: New Targets for Molecular Medicin319
- Chapter 20. New Molecular Targets for the Treatment of Neuropathic Pain339
- Chapter 21. Therapeutic Transfer and Regeneration of Neural Progenitors or Neurons in Gray Matter of357
- Chapter 22. Cellular Plasticity of the Adult Human Brain375
- Chapter 23. Harnessing Endogenous Stem Cells for Central Nervous System Repair387
- Chapter 24. Neuropathies„Translating Causes into Treatments405
- Chapter 25. Therapeutic Potential of Neurotrophic Factors419
- Chapter 26. Promoting the Regeneration of Axons within the Central Nervous System433
- Chapter 27. Alzheimer’s Disease: Clinical Features, Neuropathological and Biochemical Abnormalitie445
- Chapter 28. Behavioral Intervention and Recovery from CNS Damage459
- Chapter 29. What Functional Brain Imaging Will Mean for Neurology471
- Index493
- Color Plate Section515
The field of neurology is being transformed, from a therapeutically nihilistic discipline with few effective treatments, to a therapeutic specialty which offers new, effective treatments for disorders of the brain and spinal cord. This remarkable transformation has bridged neuroscience, molecular medicine, and clinical investigation, and represents a major triumph for biomedical research. This book, which contains chapters by more than 29 internationally recognized authorities who have made major contributions to neurotherapeutics, tells the stories of how new treatments for disabling disorders of the nervous system, such as stroke, multiple sclerosis, Parkinson’s disease, and migraine, were developed, and explores evolving themes and technologies that offer hope for even more effective treatments and ultimately cures for currently untreatable disorders of the brain and spinal cord.
The first part of this book reviews the development of new therapies in neurology, from their inception in terms of basic science to their introduction into the clinical world. It also explores evolving themes and new technologies. This book will be of interest to everyone – clinicians and basic scientists alike – interested in diseases of the brain and spinal cord, and in the quest for new treatments for these disorders.
* Presents the evolution of the field of neurology into a therapeutic discipline
* Discusses lessons learned from past successes and applications to ongoing work
* Explores the future of this field
The first part of this book reviews the development of new therapies in neurology, from their inception in terms of basic science to their introduction into the clinical world. It also explores evolving themes and new technologies. This book will be of interest to everyone – clinicians and basic scientists alike – interested in diseases of the brain and spinal cord, and in the quest for new treatments for these disorders.
* Presents the evolution of the field of neurology into a therapeutic discipline
* Discusses lessons learned from past successes and applications to ongoing work
* Explores the future of this field