Elsevier S & T

Gene Therapy Methods

Phillips, M. Ian

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Table of contents
  • Table of Contentsv
  • Contributors to Volume 346xi
  • Prefacexix
  • Volumes in Seriesxxi
  • Section I: Nonviral1
  • Chapter 1. Gene Therapy for Hypertension: The Preclinical Data3
  • Chapter 2. Oligonucleotide-Mediated Site-Directed Gene Repair14
  • Chapter 3. Stabilized Plasmid-Lipid Particles: A Systemic Gene Therapy Vector36
  • Chapter 4. Enhancing Direct in Vivo Transfection with Nuclease Inhibitors and Pulsed Electrical Fiel72
  • Chapter 5. Hydrodynamics-Based Transfection: Simple and Efficient Method for Introducing and Express92
  • Chapter 6. Bioplex Technology: Novel Synthetic Gene Delivery System Based on Peptides Anchored to Nu106
  • Chapter 7. Surgical Procedures for Intravascular Delivery of Plasmid DNA to Organs125
  • Chapter 8. Direct Gene Transfer into Mouse Heart134
  • Section II: Adenovirus143
  • Chapter 9. Myoblast-Mediated Gene Transfer for Therapeutic Angiogenesis145
  • Chapter 10. Use of Phage Display to Identify Novel Peptides for Targeted Gene Therapy157
  • Chapter 11. Helper-Dependent Adenoviral Vectors177
  • Chapter 12. Gene Transfer Methods for Transplantation199
  • Chapter 13. Generation and Growth of Gutted Adenoviral Vectors224
  • Chapter 14. Adenovirus-Mediated Gene Transfer for Cardiovascular and Renal Diseases247
  • Chapter 15. Gene Transfer to Blood Vessels Using Adenoviral Vectors263
  • Chapter 16. Rearrangements in Adenoviral Genomes Mediated by Inverted Repeats277
  • Chapter 17. High-Capacity, Helper-Dependent, GutlessŽ AdenoviralVectors for Gene Transfer into Br292
  • Chapter 18. Gene Therapy Methods in Cardiovascular Diseases311
  • Section III: Adeno-Associated Virus321
  • Chapter 19. Gene Delivery to Cardiac Muscle323
  • Chapter 20. Recombinant AAV-Mediated Gene Delivery Using Dual Vector Heterodimerization334
  • Chapter 21. Designing and Characterizing Hammerhead Ribozymes for Use in AAV Vector-Mediated Retinal358
  • Chapter 22. Adeno-Associated Viral Vector-Mediated Gene Therapy of Ischemia-Induced Neuronal Death378
  • Chapter 23. Recombinant Adeno-Associated Viral Vector Production Using Stable Packaging and Producer393
  • Chapter 24. Streamlined Large-Scale Production of Recombinant Adeno-Associated Virus (rAAV) Vectors413
  • Section IV: Lentivirus431
  • Chapter 25. Gene Transfer to the Brain Using Feline Immunodeficiency Virus-Based Lentivirus Vectors433
  • Chapter 26. Generation of HIV-1 Derived Lentiviral Vectors454
  • Chapter 27. Design, Production, Safety, Evaluation, and Clinical Applications of Nonprimate Lentivir466
  • Chapter 28. Gene Transfer to Airway Epithelia Using Feline Immunodeficiency Virus-Based Lentivirus V500
  • Chapter 29. Transduction of a Gene Expression Cassette Using Advanced Generation Lentiviral Vectors514
  • Chapter 30. Construction, Purification, and Characterization of Adenovirus Vectors Expressing Apopto529
  • Section V: Retrovirus549
  • Chapter 31. Ligand-Inducible Transgene Regulation for Gene Therapy551
  • Chapter 32. Large-Scale Production of Retroviral Vectors for Systemic Gene Delivery562
  • Chapter 33. Oncoretroviral and Lentiviral Vector-Mediated Gene Therapy573
  • Section VI: Other Strategies591
  • Chapter 34. HSV-1 Amplicon Vectors593
  • Chapter 35. Microencapsulation of Genetically Engineered Cells for Cancer Therapy603
  • Chapter 36. HVJ (Hemagglutinating Virus of Japan; Sendai Virus)-Liposome Method619
  • Chapter 37. Gene Transfer with Foamy Virus Vectors628
  • Chapter 38. Infectious Epstein–Barr Virus Vectors for Episomal Gene Therapy649
  • Author Index661
  • Subject Index711
Book details
  • Vendor Elsevier S & T
  • SKU 9780121822477
  • ISBN-13 9780080496948
  • Author Phillips, M. Ian
  • Category Science
  • Subject Research & Methodology

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Description eBook delivery & access Reviews
This volume in the prestigious Methods in Enzymology series discusses methods currently used in preclinical and clinical gene therapy. Subjects covered in this book, such as the use of adeno-associated virus delivery for treatment of Parkinson's disease, are topical and are presented in the methods-oriented style popularized by this series.

This volume in the prestigious Methods in Enzymology series discusses methods currently used in preclinical and clinical gene therapy. Subjects covered in this book, such as the use of adeno-associated virus delivery for treatment of Parkinson's disease, are topical and are presented in the methods-oriented style popularized by this series.