Genetic Recombination in Cancer
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Table of contents
- Cover
- Contentsv
- Prefaceix
- Abbreviationsxi
- Chapter 1. Introduction1
- Chapter 2. Genetic integrity, DNA repair and recombination3
- Base excision and nucleotide excision repair system5
- RAD genes and their operation in DNA replication checkpoint5
- DNA recombination repair pathway8
- VDJ recombination, the immune system and haematological malignancy9
- SET domain proteins in genetic transcription, growth regulation and myeloma12
- Ku protein in cell function15
- Chapter 3. Replication error (RER) and genetic instability24
- Microsatellite instability and cancer progression25
- Effects of microsatellite instability on p53 and growth factor gene expression28
- Influence of microsatellite instability on invasive behaviour of tumours31
- Microsatellite instability and metastasis suppressor nm23 gene abnormalities33
- Chromosomal fragile sites and the RER phenotype34
- Sister chromatid recombination and fragile sites35
- Microsatellite instability and sister chromatid recombination39
- Genomic stability and chromosome structural dynamics39
- Chapter 4. DNA repeats, genetic recombination and the pathogenesis of genetic disorders41
- CAG repeat expansion and genetic instability42
- Microsatellite dinucleotide repeats in insulin-dependent diabetes mellitus and autoimmune thyroid di49
- Alu repeats in genetic recombination50
- LINE repeats in genetic rearrangement62
- Cognate elements associated with recombination64
- Chapter 5. Chromosomal recombination in cancer67
- Karyotypic abnormalities in cancer67
- DNA aneuploidy and cancer progression68
- DNA ploidy, cell proliferation and growth factor expression70
- Association of DNA ploidy with p53 abnormalities75
- Chapter 6. Chromosomal translocation and its phenotypic effects76
- Chromosomal translocation and signal transduction76
- Chromosomal translocation and the dynamics of cell population expansion in cancer89
- The PI-3 kinase/Akt pathway of signal transduction in cell proliferation, apoptosis and differentiat96
- Chromosomal translocation and genetic transcription104
- Chromosomal translocation, fusion proteins and tumour vascularisation117
- Chromosomal translocations, fusion proteins and immunity119
- The association of chromosomal translocation with fragile sites120
- Chromosomal fragility, genetic loss and tumour suppressor genes121
- Gene amplification and its relationship to genetic instability126
- Chromosomal fragility and micronuclei128
- Chapter 7. DNA methylation and genetic instability133
- DNA methylation in normal and neoplastic development133
- Abnormal DNA methylation in ICF and Rett syndromes134
- DNA methylation and genetic instability135
- The CpG Island Methylator Phenotype (CIMP)136
- Influence of DNA methylation on recombination139
- Methylation-associated chromosomal recombination and genetic transcription in childhood leukaemias140
- The dynamics of histone acetylation in cell differentiation, cell proliferation and neoplasia140
- The effects of p53 methylation on chromosome stability149
- DNA methylation in fragile X syndrome151
- Chapter 8. Telomeric DNA and genetic instability154
- Telomeres and cell proliferation, apoptosis and cell senescence154
- Telomeres in DNA repair158
- Telomere function and ATM kinase158
- Telomeric association159
- The incidence of telomeric association in cancer159
- Telomeric association and gene expression161
- Telomere position effect162
- Epilogue164
- References170
- Index237
Genetic recombination is a process of combining genes that leads to the generation of cell variants that possess different characteristics. This process is important to the evolution of a species and to embryonic growth and differentiation. However, this process can also lead to the development of abnormal, cancerous cells. This book reviews the role of genetic recombination in the generation of various cancers and how genetic alterations have been or could be employed to elicit clinically useful information.
* Provides detailed discussion of the genetic mechanisms that result in the generation of normal and abnormal cells
* Examines the role of genetic recombination in cancer including cancer invasion and metastasis
* Information is presented in a manner that is useful and accessible to everyone from graduate students to established cancer researchers
* Provides detailed discussion of the genetic mechanisms that result in the generation of normal and abnormal cells
* Examines the role of genetic recombination in cancer including cancer invasion and metastasis
* Information is presented in a manner that is useful and accessible to everyone from graduate students to established cancer researchers