Genomic Regulatory Systems: In Development and Evolution
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Table of contents
- Contentsv
- Prefaceix
- Chapter 1. Regulatory Hardwiring: A Brief Overview of the Genomic Control Apparatus and its Causal R1
- The Regulatory Apparatus Encoded in the DNA2
- Gene Regulatory Functions in Development11
- Genomic Regulatory Sequence and the Evolution of Morphological Features18
- Chapter 2. Inside the cis-Regulatory Module: Control Logic, and How Regulatory Environment is Transd25
- Operating Principles for cis -Regulatory Systems that Mediate Developmental Specification Events26
- Spatial Repression in cis -Regulatory specification28
- Downstream of Specification44
- The "Power" of the cis -Regulatory Module49
- Chapter 3. Regulation of Direct Cell-Type Specification in Early Development63
- The Basic Package for Bilaterian Embryogenesis: Type 1 Specification Processes64
- Regulatory Mechanism in Territorial Specification of the Sea Urchin Embryo66
- Regulatory Mechanisms Controlling Specification in Ascidian Embryos81
- Caenorhabditis elegans: The Genomic Apparatus for Endoderm Specification92
- Short Summary: Quality of Type 1 Regulatory Networks101
- Chapter 4. The Secret of the Bilaterians: Abstract Regulatory Design in Building Adult Body Parts103
- The Evolutionary Significance of "Pattern Formation"103
- The First Step: Transcriptional Definition of the Domain of the Body Part105
- Morphological Pieces and Regulatory Subpatterns110
- Glimpses of How It Works122
- The Last Routines: Calling in Differentiation Programs146
- Concluding Remark153
- Chapter 5. Changes that Make New Forms: Gene Regulatory Systems and the Evolution of Body Plans157
- Some Examples: Evolutionary Cooption of Genes to New Pattern Formation Functions158
- box Gene Functions and Cooptions of the box Cluster Patterning System164
- Small Changes183
- Evolutionary Origins of Body Parts188
- Concluding Comment: Conceiving Evolution as a Process of Change in Regulatory Gene Networks201
- References203
- Index245
The interaction between biology and evolution has been the subject of great interest in recent years. Because evolution is such a highly debated topic, a biologically oriented discussion will appeal not only to scientists and biologists but also to the interested lay person. This topic will always be a subject of controversy and therefore any breaking information regarding it is of great interest.
The author is a recognized expert in the field of developmental biology and has been instrumental in elucidating the relationship between biology and evolution. The study of evolution is of interest to many different kinds of people and Genomic Regulatory Systems: In Development and Evolution is written at a level that is very easy to read and understand even for the nonscientist.
* Contents Include
* Regulatory Hardwiring: A Brief Overview of the Genomic Control Apparatus and Its Causal Role in Development and Evolution
* Inside the Cis-Regulatory Module: Control Logic and How the Regulatory Environment Is Transduced into Spatial Patterns of Gene Expression
* Regulation of Direct Cell-Type Specification in Early Development
* The Secret of the Bilaterians: Abstract Regulatory Design in Building Adult Body Parts
* Changes That Make New Forms: Gene Regulatory Systems and the Evolution of Body Plans
The author is a recognized expert in the field of developmental biology and has been instrumental in elucidating the relationship between biology and evolution. The study of evolution is of interest to many different kinds of people and Genomic Regulatory Systems: In Development and Evolution is written at a level that is very easy to read and understand even for the nonscientist.
* Contents Include
* Regulatory Hardwiring: A Brief Overview of the Genomic Control Apparatus and Its Causal Role in Development and Evolution
* Inside the Cis-Regulatory Module: Control Logic and How the Regulatory Environment Is Transduced into Spatial Patterns of Gene Expression
* Regulation of Direct Cell-Type Specification in Early Development
* The Secret of the Bilaterians: Abstract Regulatory Design in Building Adult Body Parts
* Changes That Make New Forms: Gene Regulatory Systems and the Evolution of Body Plans