Elsevier S & T

Growth and Lactogenic Hormones

Matera, L.; Rapaport, R.

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Table of contents
  • Cover
  • Contentsxix
  • Foreword: The Neuroimmune Biology of Growth and Lactogenic Hormonesv
  • Prefacexv
  • List of Corresponding Authorsxvii
  • Part I: Introduction1
  • Chapter 1. Immunoregulation by Prolactin – An Introduction3
  • Part II: GLH Biology, Development & Receptors7
  • Chapter 2. The Growth Hormone – Insulin-Like Growth Factor – I Axis and Immunity9
  • Chapter 3. Reciprocal Interactions between the GH/IGF-1 System and Cytokines27
  • Chapter 4. Biological Significance of Insulin-Like Growth Factor Binding Proteins37
  • Chapter 5. The Expression and Function of GH/IGF-I Receptors in the Immune System67
  • Chapter 6. Growth Hormone and Insulin-Like Growth Factor-1 Production by Cells of the Immune System87
  • Chapter 7. Potential Applications of Growth Hormone in Promoting Immune Reconstitution101
  • Chapter 8. Signal Transduction by PRL Receptors111
  • Chapter 9. Signal Transduction and Modulation of Gene Expression by Prolactin in Human Leukocytes123
  • Chapter 10. Regulation of PRL Release by Ccytokines and Immunomodifiers: Interrelationship between l137
  • Chapter 11. Prolactin Expression in the Immune Cells147
  • Part III: Hemopiesis and development161
  • Chapter 12. Prolactin as a Promoter of Growth and Differentiation of Hemopoietic Cells163
  • Chapter 13. Growth Hormone/Insulin-like Growth Factors and Hematopoiesis177
  • Chapter 14. Uteroplacental Prolactin Family: Immunological Regulators of Viviparity187
  • Part IV: GLH and the immune response203
  • Chapter 15. Effect of Prolactin on Natural Killer and MHC-restricted Cytotoxic Cells205
  • Chapter 16. In Vivo Changes of PRL Levels During the T-cell Dependent Immune Response219
  • Chapter 17. Prolactin regulates Macrophage and NK Cell Mediated Inflammation and Cytotoxic Response227
  • Part V: GLH and disease245
  • Chapter 18. Acromegaly and Immune Function247
  • Chapter 19. Growth Hormone and Insulin-Like Growth Factor-1 in Human Immunodeficiency Virus Infectio259
  • Chapter 20. Human Prolactin as an Immunohematopoietic Factor: Implications for the Clinic275
  • Chapter 21. Effectiveness of Bromocriptine in the Treatment of Autoimmune Diseases287
  • Chapter 22. The Pathogenic Role of Prolactin in Patients with Rheumatoid Arthritis297
  • Keyword index305
Book details
  • Vendor Elsevier S & T
  • SKU 9780444510518
  • ISBN-13 9780080507668
  • Author Matera, L.; Rapaport, R.
  • Category Medical
  • Subject Physiology

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For more than seventy years evidence has accumulated documenting the existence of a bi-directional communication network between growth hormone and the immune system. In the past twenty years there has been a tremendous proliferation of information detailing the workings of the growth hormone and insulin-like growth factor axis. A multitude of growth factors and binding proteins have been identified. More and more evidence supporting the important role of the growth hormone IGF network in the well functioning of the normal immune system has been documented. Clearly the challenge today is not to prove, but to understand, the neuroimmune regulatory role of GLH in its entire complexity.


The ultimate goal of this volume and of all the other volumes of this series is to promote the understanding of the science and to ease human suffering.