Elsevier S & T

Handbook of Stress and the Brain Part 1: The Neurobiology of Stress: The Neurobiology of Stress

Steckler, Thomas; Kalin, N.H.; Reul, J.M.H.M.

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Table of contents
  • Contentsxv
  • List of Contributorsv
  • Prefacexi
  • A Memorial for David de Wied (1925–2004)xiii
  • Section 1: Concepts of Stress1
  • Chapter 1.1. Stress: an historical perspective3
  • Chapter 1.2. The neuropsychology of stress25
  • Chapter 1.3. An introduction to the HPA axis43
  • Chapter 1.4. Hormones of the pituitary67
  • Chapter 1.5. Molecular biology of the HPA axis79
  • Chapter 1.6. The hypothalamic–pituitary–adrenal axis as a dynamically organized system: lessons95
  • Section 2: Hypothalamic Hormones Involved in Stress Responsivity113
  • Chapter 2.1. Novel CRF family peptides and their receptors: an evolutionary analysis115
  • Chapter 2.2. Molecular regulation of the CRF system133
  • Chapter 2.3. Behavioral consequences of altered corticotropin-releasing factor activation in brain:155
  • Chapter 2.4. The roles of urocortins 1, 2, and 3 in the brain179
  • Chapter 2.5. Vasopressin and oxytocin205
  • Chapter 2.6. The role of vasopressin in behaviors associated with aversive stimuli231
  • Section 3: Stress and the HPA Axis263
  • Chapter 3.1. Corticosteroid receptors and HPA-axis regulation265
  • Chapter 3.2. Glucocorticoid effects on gene expression295
  • Chapter 3.3. The role of 11β-hydroxysteroid dehydrogenases in the regulation of corticosteroid acti313
  • Chapter 3.4. Corticosteroids and the blood-brain barrier329
  • Chapter 3.5. Glucocorticoids and motivated behaviour341
  • Chapter 3.6. Effects of glucocorticoids on emotion and cognitive processes in animals359
  • Chapter 3.7. Glucocorticoids: effects on human cognition387
  • Section 4: Neurotransmitter Systems Involved in Stress Responsivity403
  • Chapter 4.1. Neurocircuit regulation of the hypothalamo–pituitary–adrenocortical stress response405
  • Chapter 4.2. Sympatho-adrenal activity and hypothalamic–pituitary–adrenal axis regulation419
  • Chapter 4.3. The locus coeruleus–noradrenergic system and stress: modulation of arousal state and437
  • Chapter 4.4. Functional interactions between stress neuromediators and the locus coeruleus–norepin465
  • Chapter 4.5. Regional specialisation in the central noradrenergic response to unconditioned and cond487
  • Chapter 4.6. Stress, corticotropin-releasing factor and serotonergic neurotransmission503
  • Chapter 4.7. Modulation of glutamatergic and GABAergic neurotransmission by corticosteroid hormones525
  • Chapter 4.8. Neuroactive steroids545
  • Chapter 4.9. Endogenous opioids, stress, and psychopathology561
  • Chapter 4.10. Acetylcholinesterase as a window onto stress responses585
  • Chapter 4.11. Pathways and transmitter interactions mediating an integrated stress response609
  • Section 5: Neuroplasticity and Stress641
  • Chapter 5.1. The intracellular signaling cascade and stress643
  • Chapter 5.2. The role of neurotrophic factors in the stress response665
  • Chapter 5.3. Transcription factors as modulators of stress responsivity679
  • Chapter 5.4. Experience, structural plasticity and neurogenesis699
  • Chapter 5.5. Adult neurogenesis in rodents and primates: functional implications711
  • Chapter 5.6. Cellular and molecular analysis of stress-induced neurodegeneration – methodological729
  • Chapter 5.7. Enhancing resilience to stress: the role of signaling cascades751
  • Section 6: The Stressed Brain773
  • Chapter 6.1. Psychological and physiological stressors775
  • Chapter 6.2. Involvement of the amygdala in the neuroendocrine and behavioral consequences of stress793
  • Chapter 6.3. Role of prefrontal cortex in stress responsivity807
  • Subject Index819
Book details
  • Vendor Elsevier S & T
  • SKU 9780444511737
  • ISBN-13 9780080553245
  • Author Steckler, Thomas; Kalin, N.H.; Reul, J.M.H.M.
  • Category Medical
  • Subject Neuroscience

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The Handbook of Stress and the Brain focuses on the impact of stressful events on the functioning of the central nervous system; how stress affects molecular and cellular processes in the brain, and in turn, how these brain processes determine our perception of and reactivity to, stressful challenges - acutely and in the long-run.
Written for a broad scientific audience, the Handbook comprehensively reviews key principles and facts to provide a clear overview of the interdisciplinary field of stress. The work aims to bring together the disciplines of neurobiology, physiology, immunology, psychology and psychiatry, to provide a reference source for both the non-clinical and clinical expert, as well as serving as an introductory text for novices in this field of scientific inquiry.



Part 1 addresses basic aspects of the neurobiology of the stress response including the involvement of neuropeptide, neuroendocrine and neurotransmitter systems and its corollaries regarding gene expression and behavioural processes such as cognition, motivation and emotionality.

* Provides an overview of recent advances made in stress research
* Includes timely discussion of stress and its effect on the immune system
* Presents novel treatment strategies targeting brain processes involved in stress processing and coping mechanisms