Elsevier S & T

Handbook of Stress and the Brain Part 2: Stress: Integrative and Clinical Aspects: Stress: Integrative and Clinical Aspects

Steckler, Thomas; Kalin, N.H.; Reul, J.M.H.M.

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Table of contents
  • Cover
  • Contents, Part 2xi
  • List of Contributors, Part 2v
  • Prefaceix
  • Section 1: Environmental and Genetic Factors Influencing Stress Reactivity1
  • Chapter 1.1. Hypothalamic–pituitary–adrenal axis in postnatal life3
  • Chapter 1.2. Early-life environmental manipulations in rodents and primates:23
  • Chapter 1.3. Gene targeted animals with alterations in corticotropin pathways: new insights into all51
  • Chapter 1.4. Rat strain differences in stress sensitivity75
  • Chapter 1.5. Glucocorticoid hormones, individual differences, and behavioral and dopaminergic respon89
  • Chapter 1.6. Social hierarchy and stress113
  • Section 2: Stress and the Immune System133
  • Chapter 2.1. Stress-induced hyperthermia135
  • Chapter 2.2. Cytokine activation of the hypothalamo–pituitary–adrenal axis157
  • Chapter 2.3. Glucocorticoids and the immune response175
  • Chapter 2.4. The molecular basis of fever193
  • Section 3: Stress and Psychiatric Disorders229
  • Chapter 3.1. Animal models of posttraumatic stress disorder231
  • Chapter 3.2. Neuroendocrine aspects of PTSD251
  • Chapter 3.3. Depression and effects of antidepressant drugs on the stress systems273
  • Chapter 3.4. A contemporary appraisal of the role of stress in schizophrenia287
  • Chapter 3.5. Atypical antipsychotic drugs and stress301
  • Chapter 3.6. The role of stress in opiate and psychostimulant addiction: evidence from animal models315
  • Chapter 3.7. Stress and drug abuse333
  • Chapter 3.8. Stress and dementia357
  • Section 4: Novel Treatment and Strategies Targeting Stress-related Disorders371
  • Chapter 4.1. CRF antagonists as novel treatment strategies for stress-related disorders373
  • Chapter 4.2. Nonpeptide vasopressin Vlb receptor antagonists409
  • Chapter 4.3. Substance P (NK1 receptor) antagonists423
  • Chapter 4.4. Glucocorticoid antagonists and depression437
  • Subject Index451
Book details
  • Vendor Elsevier S & T
  • SKU 9780444518231
  • ISBN-13 9780080553313
  • Author Steckler, Thomas; Kalin, N.H.; Reul, J.M.H.M.
  • Category Medical
  • Subject Neuroscience

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The Handbook of Stress and the Brain focuses on the impact of stressful events on the functioning of the central nervous system; how stress affects molecular and cellular processes in the brain, and in turn, how these brain processes determine our perception of and reactivity to, stressful challenges - acutely and in the long-run.
Written for a broad scientific audience, the Handbook comprehensively reviews key principles and facts to provide a clear overview of the interdisciplinary field of stress. The work aims to bring together the disciplines of neurobiology, physiology, immunology, psychology and psychiatry, to provide a reference source for both the non-clinical and clinical expert, as well as serving as an introductory text for novices in this field of scientific inquiry.



Part 2 treats the complexity of short-term and long-term regulation of stress responsivity, the role of stress in psychiatric disorders as based on both preclinical and clinical evidence, and the current status with regard to new therapeutic strategies targetting stress-related disorders.