Hormones
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Table of contents
- Cover
- Contentsv
- Preface to the First Editionxiii
- Preface to the Second Editionxvii
- Chapter 1. General Considerations of Hormones1
- I. Overview of Hormones, Receptors, and Endocrinology1
- II. Biosynthesis of Hormones9
- III. Hormone Receptors17
- IV. Mechanism of Hormonal Action33
- V. Summary46
- Chapter 2. Steroid Hormones: Chemistry, Biosynthesis, and Metabolism49
- I. Introduction49
- II. Chemistry of Steroids51
- II. Biosynthesis of Cholesterol57
- IV. Biosynthesis of Steroids65
- V. Properties of Enzymes Involved in Steroid Metabolism75
- VI. Plasma Transport, Catabolism, and Excretion of Steroid Hormones81
- Chapter 3. Hypothalamic Releasing Hormones87
- I. Introduction87
- II. Anatomical, Morphological, and Physiological Relationships90
- III. Chemistry92
- IV. Biochemistry96
- V. Clinical Aspects104
- Chapter 4. Posterior Pituitary Hormones109
- I. Introduction109
- II. Anatomy and Development of the Posterior Pituitary111
- III. Chemistry111
- IV. Biochemistry114
- V. Biological and Molecular Actions118
- VI. Clinical Aspects128
- Chapter 5. Anterior Pituitary Hormones133
- I. Introduction133
- II. Anatomical, Morphological, and Physiological Relationships135
- III. Chemistry137
- IV. Biochemistry142
- V. Prolactin142
- VI. Growth Hormone149
- VII. B-Lipotropin159
- VIII. Thyrotropic Hormone161
- IX. ACTH162
- X. Gonadotropic Hormones LH and FSH162
- XI. ACTH Receptor164
- XII. Clinical Aspects166
- Chapter 6. Thyroid Hormones169
- I. Introduction169
- II. Anatomical and Morphological Relationships170
- III. Chemistry171
- IV. Biochemistry172
- V. Biological and Molecular Actions183
- VI. Clinical Aspects189
- Chapter 7. Pancreatic Hormones: Insulin and Glucagon193
- I. Introduction193
- II. Anatomical, Morphological, and Physiological Relationships197
- III. Chemistry201
- IV. Biochemistry206
- V. Biological and Molecular Actions217
- VI. Clinical Aspects224
- Chapter 8. Gastrointestinal Hormones229
- I. Introduction229
- II. Anatomical, Morphological, and Physiological Relationships231
- III. Chemistry and Biochemistry236
- IV. Biological and Molecular Actions243
- V. Clinical Aspects247
- Chapter 9. Calcium-Regulating Hormones: Vitamin D, Parathyroid Hormone, and Calcitonin251
- I. Introduction251
- II. Anatomical, Morphological, and Physiological Relationships253
- III. Chemistry and Biochemistry258
- IV. Biology and Physiological Significance262
- V. Clinical Aspects275
- Chapter 10. Adrenal Corticoids281
- I. Introduction281
- II. Anatomy, Development, and Cellular Fine Structure of the Adrenal Cortex283
- III. Chemistry and Biochemistry285
- IV. Biological and Molecular Actions295
- V. Glucocorticoid Receptor306
- VI. Zona Reticularis and Dehydroepiandrosterone310
- VII. Mineralocorticoid Hormone310
- VIII. Clinical Aspects315
- Chapter 11. Hormones of the Adrenal Medulla319
- I. Introduction319
- II. Anatomical, Morphological, and Physiological Relationships320
- III. Chemistry321
- IV. Hormone Action and Biochemistry323
- V. Actions of Epinephrine328
- VI. Enkephalins337
- VII. Clinical Aspects338
- Chapter 12. Androgens341
- I. Introduction341
- II. Anatomical and Morphological Relationships of the Male Reproductive System342
- III. Chemistry, Biochemistry, and Biological Responses345
- IV. Physiological Relationships350
- V. Molecular Actions355
- VI. Clinical Aspects358
- Chapter 13. Estrogens and Progestins361
- I. Introduction361
- II. Anatomical and Morphological Relationships of the Female Reproductive System362
- III. Chemistry, Biochemistry, and Biological Responses367
- IV. Physiological Relationships369
- V. Biological and Molecular Actions373
- VI. Clinical Aspects380
- Chapter 14. Hormones of Pregnancy and Lactation387
- I. Introduction387
- II. Anatomical and Morphological Relationships388
- III. Chemistry, Biochemistry, and Biological Responses391
- IV. Cell Biology and Molecular Actions400
- V. Clinical Aspects409
- Chapter 15. Hormones Related to the Kidney and Cardiovascular System413
- I. Introduction413
- II. Anatomical, Morphological, and Physiological Relationships414
- III. Homeostasis of Fluid, Electrolytes, and Blood Pressure420
- IV. Hormones and Blood Cell Production434
- V. Hormones and Inflammation439
- VI. Clinical Aspects440
- Chapter 16. Prostaglandins445
- I. Introduction445
- II. Chemistry450
- III. Biochemistry450
- IV. Biological Actions454
- V. Leukotrienes (LTs)459
- VI. Clinical Aspects467
- Chapter 17. Thymus Hormones471
- I. Introduction471
- II. Anatomical and Morphological Relationships474
- III. Cell Biology475
- IV. Chemistry and Biochemistry476
- V. Biological and Molecular Actions482
- VI. Clinical Aspects483
- Chapter 18. Pineal Hormones485
- I. Introduction485
- II. Development486
- III. Anatomy and Cell Biology487
- IV. Chemistry488
- V. Biochemistry488
- VI. Biological and Molecular Actions490
- VII. Clinical Aspects494
- Chapter 19. Cell Growth Factors497
- I. Growth Factor Signal Transduction497
- II. Growth Hormone (GH) and Somatomedins (IGFs)498
- III. Interaction of IGFs with Receptors498
- IV. Signal Transduction of Receptors for GH, IGFs, and Insulin499
- V. Epidermal Growth Factor (EGF) Family500
- VI. Transforming Growth Factor-B (TGF-B) Family501
- VII. Platelet-Derived Growth Factor (PDGF)503
- VIII. Fibroblast Growth Factor (FGF)505
- IX. Nerve Growth Factor (NGF)506
- X. Hepatocyte Growth Factor (HGF, Scatter Factor)509
- Chapter 20. Hormones and Cancer513
- I. Introduction513
- II. Relation of Some Hormones to Carcinogens and Development of Cancer from Inappropriate Hormonal T513
- III. Hormone-Related Treatment of Cancer514
- IV. Hormone Receptor Status of Breast Cancers517
- V. Ectopic Production of Hormones by Tumor Cells519
- VI. Oncogenes and Hormonal Functions520
- VII. Conclusion523
- Appendix A. Compilation of Most Known Hormones in Higher Mammals and Humans525
- Appendix B. Human Blood Concentrations of Major Hormones531
- Appendix C. Clinically Relevant Endocrine Disorders535
- Appendix D. The Genetic Code539
- Appendix E. Amino Acid Abbreviations541
- Appendix F. Units of Measurement in Biological Systems543
- Index545
The newly revised and updated Hormones, Second Edition provides a comprehensive treatment of human hormones, viewed in light of modern theories of hormone action and in the context of current understanding of subcellular and cellular architecture and classical organ physiology. Each chapter presents a physiological description of the hormone system under consideration, followed by a listing of the mode-of-action of the hormone. This book includes significant advances in the molecular biology of receptors, hormones, and studies of hormone action that have transpired over the past five years. The text updates the material on enzymes related to steroid metabolism and new hormone systems, as well as providing a new chapter on hormones and cancer.
Key Features
* Completely updates the material, covering new discoveries and significant advances since the First Edition was published in 1987
* Contains new information regarding steroid hormones, the role of hormones in cancer, and a comprehensive introductory chapter
* Presents an overview of virtually all important hormones
* Provides detailed physiological, cellular, and molecular descriptions of classical human endocrine systems
* Streamlines the presentation of the First Edition, making the book easier to use and read
Key Features
* Completely updates the material, covering new discoveries and significant advances since the First Edition was published in 1987
* Contains new information regarding steroid hormones, the role of hormones in cancer, and a comprehensive introductory chapter
* Presents an overview of virtually all important hormones
* Provides detailed physiological, cellular, and molecular descriptions of classical human endocrine systems
* Streamlines the presentation of the First Edition, making the book easier to use and read