Elsevier S & T

Hormones and Signaling

August, J. Thomas

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Table of contents
  • Title Pageiii
  • Contentsix
  • Contents of Previous Volumes391
  • Contributorsv
  • Chapter 1. New Insights into Glucocorticoid and Mineralocorticoid Signaling: Lessons from Gene Targe1
  • I. Generation of Mutant Mice by Gene Targeting Provides a Valuable Tool to Study Nuclear Receptor Ac1
  • II. Targeted Disruption of the Glucocorticoid Receptor Gene in Mice Reveals Essential Functions in M2
  • III. Mice Carrying a Dna-Binding Defective Gr (Grdim) Demonstrate the Importance of Receptor Cross-t7
  • IV. Disruption of the Mineralocorticoid Receptor Gene Offers a Tool for the Molecular Analysis of It13
  • V. Outlook and Perspectives17
  • References19
  • Chapter 2. Orphan Nuclear Receptors: An Emerging Family of Metabolic Regulators23
  • I. Introduction24
  • II. Orphan Nuclear Receptors Regulate Carbohydrate and Lipid Metabolism27
  • IV. Orphan Nuclear Receptors Regulate Sterol and Steroid Hormone Metabolism43
  • V. Other Orphan Nuclear Receptors with Proposed Roles in Metabolic Control52
  • VI. Models for Nuclear Receptor Control of Metabolic Target Genes54
  • VII. Summary and Perspective65
  • Acknowledgments67
  • References67
  • Chapter 3. Nuclear Receptor Coactivators89
  • I. Nuclear Receptor Structure and Function89
  • II. Nuclear Receptor Coactivators92
  • III. Mechanisms of Coactivator Interaction101
  • IV. Coactivator Complexes105
  • V. Conclusions107
  • References108
  • Chapter 4. Cytokines and Stat Signaling113
  • I. Introduction113
  • II. Stat Domains114
  • III. Cytokine Receptors Signal through Stats119
  • IV. Receptor-Dependent Stat Activation134
  • V. Stat Nuclear Translocation142
  • VI. STATs as Transcriptional Activators144
  • VII. Negative Regulation of STAT Signaling148
  • VIII. ‘‘Nonclassical’’ Stat Functions151
  • IX. Concluding Comments153
  • References153
  • Chapter 5. Coordination of camp Signaling Events through Pka Anchoring175
  • I. Introduction175
  • II. The cAMP-Dependent Protein Kinase176
  • III. Akaps177
  • IV. Conclusions and Perspectives200
  • Acknowledgments201
  • References201
  • Chapter 6. G Protein-Coupled Extracellular Ca2+ (Ca2+ o)-Sensing Receptor (CaR): Roles in Cell Sign209
  • I. Introduction209
  • II. Cloning of a G Protein-Coupled Ca2+ o-Sensing Receptor (Car) from Bovine Parathyroid212
  • III. Disorders Caused by Inactivating or Activating Mutations of the Car215
  • IV. Signal Transduction Pathways and Biological Responses Regulated by the Car220
  • V. Tissue Distribution of the Car223
  • VI. Roles of Car in Tissues Regulating Mineral Ion Homeostasis224
  • VII. Role of the Car in Cells Uninvolved in Systemic Mineral Ion Homeostasis232
  • VIII. What Are the Signals Recognized by Cars in Nonhomeostatic Tissues?237
  • IX. Are There Subtypes of the Car or Additional Forms of Ca2+ o-Sensors/Receptors240
  • X. Conclusion242
  • References243
  • Chapter 7. Pancreatic Islet Development255
  • I. Introduction255
  • II. Development of the Endocrine Pancreas268
  • III. Signals Influencing Pancreas Development293
  • IV. Summary and Perspective300
  • Acknowledgments302
  • References302
  • Chapter 8. Genetic Analysis of Androgen Receptors in Development and Disease317
  • I. Introduction317
  • II. Androgen Receptor Functional Domains323
  • III. Functional Posttranslational Modifications of the Androgen Receptor330
  • IV. An Androgen Receptor Mutation in a Prostate Cancer Cell Line333
  • V. Concluding Remarks335
  • Acknowledgments336
  • References336
  • Chapter 9. An Antiprogestin Regulable Gene Switch for Induction of Gene Expression in Vivo343
  • I. Introduction343
  • II. Construction of Ru486 Inducible Gene Expression System344
  • III. Summary of Characteristics of the Ru486 Inducible System346
  • IV. Optimization of Inducible Gene Expression347
  • V. Protocol for Transient Transfection of Cell Cultures348
  • VI. Combining the Inducible Transactivator and Reporter into One Vector349
  • VII. Generation of a More Potent Gene Switch349
  • VIII. Construction of an Inducible Repressor351
  • IX. Regulable and Tissue-Specific Gene Expression in Transgenic Mice352
  • Acknowledgments355
  • References355
  • Chapter 10. Steroid Receptor Knockout Models: Phenotypes and Responses Illustrate Interactions betwe357
  • I. Introduction357
  • II. Mammalian Reproduction358
  • III. Phenotypes of Erko Illustrate the Normal Roles of Estradiol359
  • IV. Nuclear/Membrane Receptor Cross-Talk373
  • V. Conclusions376
  • References376
  • Index381
Book details
  • Vendor Elsevier S & T
  • SKU 9780120329489
  • ISBN-13 9780080522395
  • Author August, J. Thomas
  • Category Medical
  • Subject Pharmacology

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Hormones and Signaling focuses on the mechanisms of gene regulation at the cellular level. It also describes the actions of hormones in modulating gene regulation and animal development.

Key Features
* Glococorticoid and mineralcorticoid signaling
* Orphan nuclear receptors
* Nuclear receptor coactivators
* Cytokines and STAT signaling
* Coordination of cAMP signaling events through PKA anchoring
* G protein-coupled extracellular Ca2+ (Ca2+0)-sensing receptor (CaR)
* Pancreatic islet development
* Genetic analysis of androgen receptors in development and disease
* Antioprogestin regulable gene switch for induction of gene expression in vivo
* Steroid receptor knockout model