Elsevier S & T

Hormones and Signaling

Birnbaumer, Lutz; Darnell, James; Evans, Ronald; Hunter, Tony; Means, Anthony R.; Wylie, Vale; O'Mal

In stock
No reviews
43.000 KD inc. VAT
License
Table of contents
  • Contentsv
  • Contributorsxi
  • Prefacexiii
  • Chapter 1. Glucocorticoids and Oxysterols in Lymphoid Apoptosis1
  • I. Introduction2
  • II. Mechanisms of Action of the Glucocorticoid Receptor3
  • III. Actions of Oxysterols on Lymphoid Cells6
  • IV. Apoptosis7
  • V. Glucocorticoids and Oxysterols Cause Apoptosis of CEM Cells12
  • VI. Conclusions31
  • References32
  • Chapter 2. RAGE: A Receptor with a Taste for Multiple Ligands and Varied Pathophysiologic States41
  • I. Introduction42
  • II. Identification and Characterization of RAGE42
  • III. Expression and Functions of RAGE: Endothelial Cells and Mononuclear Phagocytes47
  • IV. RAGE and Diabetes51
  • V. RAGE and Amphoterin55
  • VI. RAGE and Alzheimer's Disease56
  • VII. Hypothesis60
  • References61
  • Chapter 3. The Function and Regulation of the G-Protein-Coupled Receptor Kinases65
  • I. Introduction66
  • II. The Regulation of Cellular Signaling66
  • III. The G-Protein-Coupled Receptor Kinases69
  • IV. The Regulation of the G-Protein-Coupled Receptor Kinases71
  • V. Kinase Enzymology76
  • VI. Receptor-Kinase Specificity76
  • VII. Animal Models79
  • VIII. Physiological Significance81
  • IX. Conclusions83
  • References83
  • Chapter 4. Characteristics and Function of the Novel Estrogen Receptor β89
  • I. Introduction90
  • II. Cloning of ERβ cDNA91
  • III. Ligand-Binding Characteristics of ERβ Protein95
  • IV. Transactivation Function of ERβ Protein99
  • V. Expression of ERβ mRNA101
  • VI. Physiological Role of ER/3 Protein103
  • VII. Concluding Remarks106
  • References107
  • Chapter 5. EGF Family Receptors and Their Ligands in Human Cancer113
  • I. Introduction114
  • II. EGF Family Receptors114
  • III. EGF-like Growth Factors121
  • IV. Activation of EGF Family Receptors130
  • V. Clinical Significance of EGF Family Receptors136
  • VI. Potential Clinical Application by Targeting of EGF Family Receptor Members and Ligands139
  • VII. Conclusion145
  • References146
  • Chapter 6. Fertilization: Common Molecular Signaling Pathways across the Species167
  • I. Introduction167
  • II. Oviductal Transport168
  • III. Motility Modulation170
  • IV. Gamete Adhesion183
  • V. Acrosome Reaction185
  • VI. Egg Plasma Membrane Interactions and Egg Activation192
  • References195
  • Chapter 7. The JNK Family of MAP Kinases: Regulation and Function209
  • I. Introduction210
  • II. Regulation of c-Jun Expression and Activity212
  • III. Phosphorylation of the c-Jun Amino-Terminal Sites by JNK213
  • IV. Signal Transduction Pathways Leading to Activation of JNK and Other MAP Kinases216
  • V. Other Substrates for the JNKs222
  • VI. Biological Functions of JNK and Other MAP Kinase Pathways224
  • VII. Conclusions and Future Considerations227
  • References228
  • Chapter 8. PPARα: Tempting Fate with Fat235
  • I. PPARα as a Ligand-Activated Transcription Factor236
  • II. Lipid Homeostasis: How Complex Can It Be?237
  • III. PPARα Expression during Development and Adulthood242
  • IV. PPARα and Its Activators: Open Relationships?243
  • V. PPARα Ligands251
  • VI. PPARα Functions251
  • VII. Conclusion255
  • References255
  • Chapter 9. Molecular Mechanisms of Neuronal Survival and Apoptosis257
  • I. The Neurotrophic Theory259
  • II. Apoptosis„A Means of Neuronal Death261
  • III. Activity, Intracellular Calcium, and Survival262
  • IV. The Calcium Set-Point Hypothesis263
  • V. Mechanisms of Survival: Neurotrophin Receptors and Second Messengers264
  • VI. The Ras-MAPK Pathway266
  • VII. The Phosphatidylinositide-3'-OH Kinase/Akt Pathway270
  • VIII. Protein Kinase C273
  • IX. Neurotrophin-Dependent Pathway Cross-Talk274
  • X. Calcium-Dependent Kinase Pathways274
  • XI. Interaction of Calcium and Neurotrophin Signaling in Survival276
  • XII. Mechanisms of Death278
  • XIII. Upstream Events in Neuronal Death and p75278
  • XIV. Death and Second Messengers: Ceramide and JNK/p38281
  • XV. Signal Integration: The Balance between Life and Death285
  • XVI. Caspases and the Bcl-2 Family288
  • XVII. Cell-Extrinsic Signaling Meets Cell-Intrinsic Survival and Death Mechanisms291
  • XVIII. Frontiers in Neuronal Survival and Death292
  • References292
  • Chapter 10. Nuclear Orphan Receptors: The Search for Novel Ligands and Signaling Pathways307
  • I. Introduction308
  • II. Discovery of Orphan Receptor Ligands315
  • III. Orphan Receptors That Function as RXR Heterodimers319
  • IV. Orphan Receptors That Function Independently of Dimerization with RXR327
  • V. Summary and Perspective340
  • References342
  • Index359
Book details
  • Vendor Elsevier S & T
  • SKU 9780123124111
  • ISBN-13 9780080534145
  • Author Birnbaumer, Lutz; Darnell, James; Evans, Ronald; Hunter, Tony; Means, Anthony R.; Wylie, Vale; O'Mal
  • Category Medical
  • Subject Endocrinology & Metabolism

Do you have questions about this book?

Ask an expert!

Description eBook delivery & access Reviews
Hormones and Signaling focuses on the mechanism of gene regulation at the cellular level. It also covers the way hormones act to modulate gene regulation and animal development.

Key Features
* Includes information on:
* Nuclear receptors, coactivators, and corepressors
* Membrane receptors, kinases, and phosphorylation on cascades
* Hormonal regulation of development
* Calcium channels and neurotransmitters
* Chromatin, transcription factors, and regulation of gene expression
* JAK/STAT pathways
* Hormone-regulated development and gene "knock-out"