Immunology: The Making of a Modern Science: The Making of a Modern Science
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Table of contents
- Contentsv
- Introduction1
- Foreword3
- Chapter 1. The Historical Origins of Modern Immunology5
- Theories of Immunity21
- Chapter 2. Origins of the Cell Selection Theories of Antibody Formation23
- Chapter 3. One Cell – One Antibody39
- Chapter 4. Roots of and Routes to Autoimmunity49
- The Cellular Basis of Immunity63
- Chapter 5. The Mysterious Lymphocyte65
- Chapter 6. The Discovery of Thymus Function75
- Chapter 7. About the Discovery of MHC-restricted T Cell Recognition85
- Chapter 8. Two-signal Models of Lymphocyte Activation95
- Chapter 9. Ontogeny of the Immune Response103
- The Molecular Basis of Immunity109
- Chapter 10. The HLA Story111
- Chapter 11. Early Investigations on Antibody Structure and Idiotypy121
- Chapter 12. The Contribution of the Cytokine Concept to Immunology133
- Chapter 13. Somatic Generation of Antibody Diversity145
- Chapter 14. Tracking an Imaginary Monster: Isolating T Cell Receptor Genes163
- Immunology and Medicine177
- Chapter 15. Organ Transplantation and the Revitalization of Immunology179
- Chapter 16. Immediate Hypersensitivity: A Brief History191
- Chapter 17. Tumour Immunology203
- Chapter 18. Hepatitis B Virus and Vaccine223
- Chapter 19. Studies of Thyroid Autoimmunity: Their Role in Shaping Modern Immunology231
- Index237
Immunology has progressed in spectacular fashion in the last four decades. Studies of the response to infectious agents, transplanted organs and tumours (and the potential to manipulate that response), and the study of the immune system as a model system in molecular cell biology have yielded dramatic advances in our understanding of the mechanisms of immunity.
The field has attracted a continuous stream of the brightest theoretical and experimental scientists for over forty years. This book conveys the philosophies and approaches of sixteen of the most successful of these scientists in the form of a series of narratives that describe the circumstances that led to a major discovery in immunology. Contributors not only recall an exciting period of research that helped shape modern immunology, but set it in the personal context of place and time. Jacques Miller, for example, describes the discovery of the function of the thymus, Rolf Zinkernagel explains how experiments on viral immunity led to the discovery of MHC restriction and Susumu Tonegawa provides an account of how antibody gene structure was defined. Medically-important discoveries include descriptions of early studies of autoimmunity by Noel Rose and of tumour immunology by George and Eva Klein.
Far from being a collection of disinterested, historical accounts, this volume comprises a series of passionately biographical, personal essays that provide an unusually intimate insight into the scientific process. This book will be essential, and fascinating, reading for all those with an interest in immunology, and in the life sciences in general. For students and teachers, this will provide the background necessary for a true understanding of immunology, and to place subsequent discoveries in perspective.
The field has attracted a continuous stream of the brightest theoretical and experimental scientists for over forty years. This book conveys the philosophies and approaches of sixteen of the most successful of these scientists in the form of a series of narratives that describe the circumstances that led to a major discovery in immunology. Contributors not only recall an exciting period of research that helped shape modern immunology, but set it in the personal context of place and time. Jacques Miller, for example, describes the discovery of the function of the thymus, Rolf Zinkernagel explains how experiments on viral immunity led to the discovery of MHC restriction and Susumu Tonegawa provides an account of how antibody gene structure was defined. Medically-important discoveries include descriptions of early studies of autoimmunity by Noel Rose and of tumour immunology by George and Eva Klein.
Far from being a collection of disinterested, historical accounts, this volume comprises a series of passionately biographical, personal essays that provide an unusually intimate insight into the scientific process. This book will be essential, and fascinating, reading for all those with an interest in immunology, and in the life sciences in general. For students and teachers, this will provide the background necessary for a true understanding of immunology, and to place subsequent discoveries in perspective.