International Review of Cell and Molecular Biology
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Table of contents
- Contentsv
- Contributorsvii
- Chapter 1: Transgenic Mouse Models of Angiogenesis and Lymphangiogenesis1
- 1. Introduction2
- 1.1. Angiogenesis2
- 1.2. Lymphangiogenesis4
- 2. Factors Involved in Abnormal Embryonic Vascular and Lymphatic Development6
- 2.1. VEGF family8
- 2.2. Growth factors12
- 2.3. Angiopoietins, Tie-1, and Tie-215
- 2.4. Hypoxia-inducible factor 118
- 2.5. Other factors18
- 3. Concluding Remarks25
- Acknowledgments26
- References26
- Chapter 2: Morphogenesis in Giant-Celled Algae37
- 1. Introduction38
- 2. Biological Features of Giant-Celled Algae39
- 2.1. Taxonomic and ecological aspects39
- 2.2. Cellular organization39
- 2.3. Motility of organelles42
- 3. Cytoskeletal Organization During Morphogenesis44
- 3.1. Vegetative morphogenesis45
- 3.2. Reproductive morphogenesis54
- 3.3. Wound-healing reaction55
- 4. Physiological and Molecular Biological Aspects of Morphogenesis59
- 4.1. Physiological factors controlling morphogenesis59
- 4.2. Expression of genes controlling morphogenesis in Acetabularia70
- 5. Concluding Remarks72
- References73
- Chapter 3: Plasmodium in the Postgenomic Era: New Insights into the Molecular Cell Biology of Malari85
- 1. Introduction86
- 2. Cellular and Molecular Biology of Red Blood Cell Invasion87
- 2.1. Structure of merozoites88
- 2.2. Merozoite assembly92
- 2.3. Merozoite exit from infected red blood cells93
- 2.4. Invasion93
- 3. Proteases100
- 3.1. Invasion-related proteases100
- 3.2. Proteases of intracellular stages101
- 4. Protein Trafficking106
- 4.1. Trafficking to intracellular compartments of parasites107
- 4.2. Export to infected red blood cell cytoplasm and surface109
- 4.3. Cytoadherence111
- 5. Cellular Calcium Dynamics113
- 5.1. Fluorescent and chemiluminescent probes to study Ca2+ in living cells113
- 5.2. Calcium-handling mechanisms in Plasmodium115
- 5.3. From genome to cell physiology115
- 5.4. Parasite organelles as intracellular Ca2+ pools116
- 5.5. Surviving in low-[Ca2+] parasitophorous vacuoles118
- 5.6. Circadian rhythms, malarial infection, and Ca2+ signaling: modulation of Plasmodium cell cycle119
- 5.7. Signal transduction-handling machinery in Plasmodium120
- 6. Molecular Biological Approaches to Plasmodium Studies123
- 6.1. Transfection technology123
- 6.2. Transfection in Plasmodium species124
- 6.3. Knockout125
- 6.4. Analysis of Transcription in Plasmodium126
- 7. Concluding Remarks134
- Acknowledgments134
- References134
- Chapter 4: Role of Nuclear Lamins in Nuclear Organization, Cellular Signaling, and Inherited Disease157
- 1. Introduction158
- 2. Structure and Organization of Lamins160
- 2.1. Genes and expression of lamin isoforms160
- 2.2. Lamin structure, assembly, and dynamics162
- 2.3. Lamin-binding proteins165
- 3. Genetic Diseases Associated with Mutations in Lamins and Nuclear Envelope Proteins169
- 3.1. Diseases caused by mutations in lamin A169
- 3.2. Diseases caused by mutations in lamin B174
- 3.3. Disorders associated with mutations in other nuclear envelope proteins175
- 3.4. Animal models for laminopathies175
- 4. Role of Lamins in Nuclear Organization and Cellular Functions177
- 4.1. Nuclear morphology and chromatin organization177
- 4.2. Regulation of mitosis179
- 4.3. DNA replication180
- 4.4. Transcription and gene regulation181
- 4.5. Nuclear–cytoskeletal interactions182
- 4.6. Apoptotic events involving lamins182
- 5. Cellular Signaling Pathways Involving Lamins183
- 5.1. Muscle differentiation183
- 5.2. Adipocyte differentiation186
- 5.3. DNA repair pathways187
- 5.4. Transforming growth factor-beta-mediated signaling pathways188
- 5.5. Cellular proliferation188
- 6. Concluding Remarks189
- Acknowledgments190
- References190
- Chapter 5: New Insights into the Mechanisms of Macroautophagy in Mammalian Cells207
- 1. Introduction208
- 2. Autophagy Proteins and Their Known Functions212
- 2.1. Atg12–Atg5213
- 2.2. Atg8/LC3213
- 2.3. Beclin 1 and Vps34217
- 2.4. Atg9219
- 2.5. Atg15219
- 3. Maturation of Autophagosomes into Autolysosomes219
- 3.1. Multistep maturation process219
- 3.2. Factors required for autophagosome maturation in mammalian cells222
- 4. Functions and Regulation of Autophagy228
- 4.1. Functions228
- 4.2. Regulation232
- 5. Concluding Remarks236
- Acknowledgments236
- References236
- Index249
International Review of Cell & Molecular Biology presents current advances and comprehensive reviews in cell biology – both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Articles in this volume include Transgenic Mouse Models in Angiogenesis and Lymphangiogenesis,
Morphogenesis in Giant-celled Algae,
Plasmodium in the Post-Genomic Era: New Insight into the Molecular Cell Biology of Malaria Parasites, Role of Nuclear Lamins in Nuclear Organization, Cellular Signalling and Inherited Diseases, New Insights into the Mechanisms of Macroautophagy in Mammalian Cells.
*Covers the latest on transgenic mouse models in angiogenesis and lymphangiogenesis.
*Includes information on morphogenesis in giant-celled algae.
*Provides new insights into the mechanisms of macroautophagy in mammalian cells.
Morphogenesis in Giant-celled Algae,
Plasmodium in the Post-Genomic Era: New Insight into the Molecular Cell Biology of Malaria Parasites, Role of Nuclear Lamins in Nuclear Organization, Cellular Signalling and Inherited Diseases, New Insights into the Mechanisms of Macroautophagy in Mammalian Cells.
*Covers the latest on transgenic mouse models in angiogenesis and lymphangiogenesis.
*Includes information on morphogenesis in giant-celled algae.
*Provides new insights into the mechanisms of macroautophagy in mammalian cells.