International Review Of Cytology: A Survey of Cell Biology
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Table of contents
- Title pageiii
- Copyright Pageiv
- Contentsv
- Contributorsvii
- Chapter 1: Cell Proliferation in Pathogenesis of Esophagogastric Lesions in Pigs1
- I. Introduction2
- II. Morphofunctional Features of Swine Stomach3
- III. Esophagogastric Ulcer in Swine10
- A. Etiology and Pathogenesis10
- B. Pathomorphological Findings15
- C. Clinical Picture and Differential Diagnosis22
- D. Therapy and Prophylaxis23
- E. Forensic Evaluation24
- IV. Concluding Remarks27
- References27
- Chapter 2: Molecular Mechanism of Phase I and Phase II Drug-Metabolizing Enzymes: Implications for D35
- I. Introduction35
- II. Phase I: NADPH-Cytochrome P450 Reductase (P450R)/Cytochrome P450 (P450) System36
- A. Historical Perspectives37
- B. P450R/P450 Electron Transfer System38
- C. Antley-Bixler Syndrome/Missense Mutations of P450R55
- III. Phase II: UDP-Glucuronosyltransferase (UGT)56
- A. Historical Perspective57
- B. UGT59
- C. Hyperbilirubinemia67
- IV. Coordinated Biotransformation by P450 and UGT73
- A. Subcellular Localization of the P450R/P450 System and UGT73
- B. Functional Interaction of P450s and UGTs in the ER75
- C. Broad Substrate Specificity81
- D. Biotransformation of Phenol Compounds84
- V. Concluding Remarks88
- Acknowledgments89
- References89
- Further Reading112
- Chapter 3: Effects of Growth Factors on Testicular Morphogenesis113
- I. Introduction113
- II. Comparative Testicular Morphogenesis114
- III. Cell Migration118
- A. Germ Cells118
- B. Peritubular Myoid Cells/Endothelial Cells/Mesonephric Cells120
- IV. Vascular Development125
- A. Vascular Endothelial Growth Factor127
- B. Follistatin and Bmp2127
- V. Proliferation128
- A. Germ Cells128
- B. Somatic Cells132
- VI. Control of Cell Phenotype/Differentiation139
- A. Germ Cell Control139
- B. Sertoli Cell Control/Testicular Cord Formation144
- C. Leydig Cell Control150
- D. Peritubular Myoid Cell Control152
- VII. Experimental Manipulations In Vitro153
- VIII. Concluding Remarks158
- Acknowledgments161
- References161
- Further Reading173
- Chapter 4: Flagellar Length Control in Chlamydomonas-A Paradigm for Organelle Size Regulation175
- I. Introduction175
- II. Size of Organelles176
- A. Size Control176
- B. Flagella and Cilia179
- C. Phenomenological Studies of Flagellar Length Control182
- D. Genetic Analysis of Flagellar Length Control188
- III. Models for Flagellar Length Control System192
- A. Molecular Ruler192
- B. Quantal Production194
- C. Cumulated Strain Model195
- D. Feedback Model197
- E. Balance Point Model198
- IV. Conclusion: What Have We Learned from Flagellar Length Control?203
- A. Length Control as Pharmacological Target for Ciliary Disease203
- B. Flagellar Length Control as Paradigm for General Organelles204
- C. Lenght Control in Nanotechnology207
- References207
- Chapter 5: Molecular Mechanism and Evolutional Significance of Epithelial-Mesenchymal Interactions i213
- I. Introduction214
- A. Region-Dependent Progression of Skin Remodeling in Anuran Metamorphosis214
- B. Evolutional Significance of Anuran Skin Metamorphosis216
- C. Regulation of Metamorphosis by Thyroid Hormone216
- II. Anuran Skin Remodeling and Metamorphosis217
- A. Development of Anuran Skin from the Late Embryonic Stage to the Adult217
- B. Molecular Probes for Anuran Epidermal Cells220
- C. Evidence That Basal Cells Include Epidermal Stem Cells and Larval Basal Cells Possess the Potenti224
- D. Skin Transformation Center230
- III. Epithelial-Mesenchymal Interactions and Larval Skin Remodeling234
- A. Tail- and Body-Dependent Metamorphic Fate of Larval Skin234
- B. Platelet-Derived Growth Factor (PDGF)-A Signaling as a Molecular Cue in TH-Induced Skin Remodelin235
- C. The Skin of Vertebrates: Evolutional Significance of Anuran Skin Metamorphosis239
- IV. Genes Involved in Anuran Tissue Remodeling243
- A. Unique Utilization of TH Response Element in Metamorphosis-Associated Genes243
- B. Regulation of Gene Expression in Larval Tissue Remodeling248
- V. Concluding Remarks252
- Acknowledgment253
- References253
- Further Reading260
- Index261
International Review of Cytology presents current advances and comprehensive reviews in cell biology – both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Articles in this volume include Cell Proliferation in pathogenesis of Oesophagogastric Lesions in Pigs; Molecular Mechanism of Phase-I and Phase-II Drug-Metabolizing Enzymes: Implications for Detoxification; Effects of Growth Factors on Testicular Morphogenesis; Flagellar Length Control in Chlamydomonas – a Paradigm for Organelle Size Regulation; and Molecular Mechanism and Evolutional Significance of Epithelial-mesenchymal Interactions in the Body- and Tail-Dependent Metamorphic Transformation of Anuran Larval Skin.