International Review Of Cytology: A Survey of Cell Biology
Regular price
88.750 KD
inc. VAT
Couldn't load pickup availability
Table of contents
- Copyright Pageiv
- Contentsv
- Contributorsvii
- Chapter 1: Mechanisms of Gradient Detection: A.Comparison of Axon Pathfinding with Eukaryotic Cell M1
- 1. Introduction2
- 2. Mechanisms of Gradient Detection in Selected Eukaryotic Cell Types4
- 2.1. Chemotaxis of Dictyostelium4
- 2.2. Chemotaxis of mammalian neutrophils10
- 2.3. Chemotaxis of mammalian fibroblasts14
- 2.4. Pathfinding of neuronal growth cones19
- 3. Common Grounds and Diversity41
- 3.1. Signaling pathways41
- 3.2. Signal amplification47
- 3.3. Adjustment of sensitivity/adaptation49
- 3.4. Biological and functional context50
- 4. Concluding Remarks51
- Acknowledgments52
- References52
- Chapter 2: Leptin and the Regulation of the Hypothalamic-Pituitary-Adrenal Axis63
- 1. Introduction64
- 2. Biology of Leptin and Its Receptors65
- 2.1. Leptin65
- 2.2. Leptin receptors68
- 3. Expression of Leptin and Its Receptors in the Hypothalamic-Pituitary-Adrenal Axis69
- 3.1. Hypothalamus69
- 3.2. Anterior pituitary70
- 3.3. Adrenal gland73
- 4. Effects of Leptin on the Central Branch of the Hypothalamic-Pituitary-Adrenal Axis76
- 4.1. Hypothalamus and CRH secretion76
- 4.2. Anterior pituitary and ACTH secretion77
- 5. Effects of Leptin on the Peripheral Branch of the Hypothalamic-Pituitary-Adrenal Axis78
- 5.1. Adrenal cortex78
- 5.2. Other steroid-secreting cells83
- 5.3. Adrenal medulla84
- 6. Involvement of Leptin in the Pathophysiology of the Hypothalamic-Pituitary-Adrenal Axis85
- 6.1. Response to stresses85
- 6.2. Pituitary adenomas86
- 6.3. Adrenocortical tumors and pheochromocytomas86
- 6.4. Macronodular adrenal hyperplasia87
- 6.5. Hyperreninemic hypoaldosteronism87
- 7. Concluding Remarks88
- Acknowledgments89
- References89
- Chapter 3: Focal Adhesion Kinase and p53 Signaling in Cancer Cells103
- 1. Introduction104
- 2. Structure and Function of Focal Adhesion Kinase Protein105
- 2.1. FAK structure105
- 2.2. FAK functioning in cells111
- 2.3. FAK-protein binding partners114
- 3. FAK in Tumorigenesis122
- 3.1. Overexpression in tumors122
- 3.2. FAK and stem cells128
- 4. FAK and p53 Association129
- 4.1. Structure and function of the p53 protein130
- 4.2. p53 mutations in cancer cells132
- 4.3. p53 binds the FAK promoter132
- 4.4. Direct FAK and p53 protein binding133
- 4.5. Cytoplasmic-nuclear protein shuttling133
- 4.6. Feedback model of FAK-p53 protein interaction134
- 5. FAK and p53 Targeted Therapy136
- 5.1. Downregulation of FAK136
- 5.2. FAK inhibitors136
- 5.3. Targeting protein-protein interactions137
- 5.4. p53 therapy137
- 6. Summary138
- Acknowledgments138
- References138
- Chapter 4: Cell and Molecular Biology of the Spindle Matrix155
- 1. Introduction156
- 2. Microtubule Spindle Dynamics and Force Production157
- 3. Evidence for a Spindle Matrix161
- 3.1. Early indications of abundant nonmicrotubule components of the spindle and spindle remnants163
- 3.2. Chromosome movement after UV microbeam severing of microtubules164
- 3.3. Molecular identification of a multiprotein spindle matrix complex in Drosophila165
- 3.4. Spindle length and the spindle matrix173
- 3.5. Membranes and the spindle matrix174
- 3.6. Other molecular candidates for an internal spindle matrix structural element175
- 3.7. Spindle assembly factors (SAFs) and the spindle matrix184
- 4. Concluding Remarks188
- Acknowledgments190
- References190
- Chapter 5: Mitochondrial Biology and Disease in Dictyostelium207
- 1. Introduction208
- 2. Mitochondrial Biology209
- 2.1. Mitochondrial genetics209
- 2.2. Protein import into mitochondria215
- 2.3. Mitochondrial morphology and division217
- 2.4. Mitochondria and programmed cell death in Dictyostelium221
- 3. Mitochondrial Disease223
- 3.1. Mitochondrial disease in humans223
- 3.2. Genetic methods for creating mitochondrial disease in Dictyostelium225
- 3.3. Mitochondrial disease phenotypes and associated signaling pathways229
- 3.4. Phenotypic thresholds in mitochondrial disease in Dictyostelium235
- 3.5. Phenotypes associated with mitochondrial defects not known to affect respiration236
- 3.6. AMPK-the missing link between phenotype and genotype in mitochondrial disease238
- 3.7. Implications241
- 4. Concluding Remarks242
- References243
- Chapter 6: Oxytocin and the Human Prostate in Health and Disease253
- 1. Introduction254
- 2. The Human Prostate254
- 2.1. Structure254
- 2.2. Functions257
- 3. Oxytocin and Oxytocin Receptor259
- 3.1. Regulation and structure260
- 3.2. Signaling pathways used by the oxytocin receptor262
- 4. Oxytocin and the Prostate264
- 4.1. Overview of oxytocin and neurophysin in the male reproductive tract264
- 4.2. Local production of oxytocin and neurophysin in the prostate267
- 4.3. Functions of oxytocin in the prostate270
- 4.4. Oxytocin and prostate disease272
- 5. Possible Roles of Oxytocin in the Pathophysiology of Prostate Disease274
- 5.1. Benign prostatic hyperplasia275
- 5.2. Carcinoma of the prostate275
- 5.3. Problems with animal models of human prostate disease276
- 5.4. Possible therapeutic roles for oxytocin277
- 6. Concluding Remarks278
- References278
- Index287
International Review of Cytology presents current advances and comprehensive reviews in cell biology – both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Articles in this volume include Mechanisms of Gradient Detection: A Comparison of Axon Pathfinding with Eukaryotic Cell Migration; Leptin and the Regulation of Hypothalamic-Pituitary-Adrenal Axis; Focal Adhesion and p53 Signaling in Cancer Cells; Cell and Molecular Biology of the Spindle Matrix; Mitochondrial Biology and Disease in Dictyostelium; Oxytocin and the Human Prostate in Health and Disease.