INTERNATIONAL REVIEW OF CYTOLOGY V162A
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Table of contents
- Structural and Functional Organization of the Nuclear Matrixiii
- Copyright Pageiv
- Contentsv
- Contributorsxi
- Prefacexv
- List of Abbreviationsxviii
- Chapter 1. The Nuclear Matrix: A Structural Mileu for Nuclear Genomic Function1
- I. Introduction2
- II. The in Situ Nuclear Matrix3
- Ill. The Isolated Nuclear Matrix10
- IV. Nuclear Matrix Proteins23
- V. Nuclear Matrix Functions36
- VI. The Nuclear Matrix and DNA Replication39
- VII. Concluding Remarks53
- References54
- Chapter 2. The Architectural Organization of Nuclear Metabolism67
- I. Introduction67
- II. Function Domains of the Nucleus69
- III. The Nuclear Matrix: History and Definition81
- IV. Ultrastructure of the Nuclear Matrix86
- V. The Core Filaments of the Nuclear Matrix91
- VI. Role for RNA in Nuclear Structure97
- VII. Architectural Organization of RNA Metabolism on the Nuclear Matrix99
- VIII. Nuclear Matrix and Phenotype105
- IX. Nuclear Matrix in Malignancy106
- X. Concluding Remarks110
- References111
- Chapter 3. The Structural Basis of Nuclear Function125
- I. Introduction125
- II. Nucleoskeletons and Chromatin Loops129
- III. Attached Polymerases131
- IV. Replication and Transcription139
- V. Repair Replication139
- VI. Attachment Sites in a Model Loop140
- VII. Mitotic Chromosomes141
- VIII. Relationship to Studies on Other Structures142
- IX. Conclusion143
- References144
- Chapter 4. Nuclear Domains and the Nuclear Matrix151
- I. Introduction151
- II. Transcription Machinery and Transcripts153
- III. RNA Processing Machinery159
- IV. DNA Synthesis Machinery165
- V. Nuclear Domains with Unknown Function167
- VI. Chromosome Domains170
- VII. Concluding Remarks173
- Reference175
- Chapter 5. The Nuclear Matrix and the Regulation of Chromatin Organization and Function191
- I. Introduction191
- II. Organization of DNA within the Nucleus192
- III. Core Histone Variants202
- IV. Modifications of the Core Histones203
- V. Histone H1214
- VI. High Mobility Group Proteins217
- VII. Chromatin Domain218
- VIII. Concluding Remarks234
- References235
- Chapter 6. Contributions of Nuclear Architecture to Transcriptional Control251
- I. Introduction251
- II. Control of the Cell Cycle-Regulated Histone Genes and the Bone-Specific Osteocalcin Gene during253
- III. Nuclear Structure and Cell Cycle Stage-Specific Expression of Histone Genes in Proliferating O263
- IV. Nuclear Structure and Developmental and Steroid the Hormone-Responsive Expression of the Osteoca265
- V. Conclusions269
- References271
- Chapter 7. Chromatin Domains and Prediction of MAR Sequences279
- I. Introduction280
- II. Methods for MAR Identification and Matrix Isolation281
- III. Identification of MAR Sequences within Various Genes289
- IV. Proteins of the Nuclear Matrix293
- V. MARs as Transcription Enhancers309
- VI. Replication and Matrix313
- VII. Repair Occurs on the Nuclear Matrix316
- VIII. Rules Diagnostic for the Prediction of MAR/ORI Sequences317
- IX. Other Features of MAR/ORI DNA357
- X. The Project of Random Cloning of MARs362
- XI. Conclusions363
- References366
- Chapter 8. Scaffold/Matrix-Attached Regions: Structural Properties Creating Transcriptionally Active389
- I. Introduction389
- II. Human Interferon-ß: Does it From a Prototype Domain?390
- III. S/MAR Structural Features Leading to Scaffold Association: Superhelicity, Strand Separation, an411
- IV. S/MARs and Transcriptional Regulation417
- V. S/MARs as Domain Borders: Model Studies425
- VI. S/MARs as Integration Targets435
- VII. Creating and Reusing Artificial Domains438
- VIII. Understanding S/MAR Functions: How Far Are Results Supported by Theory?440
- References444
- Chapter 9. Origins of Replication and the Nuclear Matrix: The DHFR Domain as a Paradigm455
- I. Introduction455
- II. Functional Organization of the Eukaryotic Genome456
- III. Initiation of DNA Replication in Mammalian Cells463
- IV. Chromosomal Structure and Initiation of DNA Replication in the Chinese Hamster DHFR Domain: An A473
- References477
- Chapter 10. The Nuclear Matrix and Virus Function485
- I. Introduction485
- II. Methodological Aspects490
- III. Structural Topography of SV40 DNA Replication495
- IV. Stages of SV40 Virion Assembly520
- V. Concluding Remarks528
- References533
- Chapter 11. The Nuclear Matrix as a Site of Anticancer Drug Action539
- I. Introduction539
- II. Nuclear Matrix and Chromatin Organization541
- III. Alkylating Agents545
- IV. Ionizing Radiation547
- V. Antimetabolites549
- VI. Topoisomerase II-Active Durgs556
- VII. Concluding Remarks564
- References566
- Index577
INTERNATIONAL REVIEW OF CYTOLOGY V162A