Elsevier S & T

International Review of Neurobiology

Bradley, Ronald J.

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Table of contents
  • CONTENTSv
  • CONTRIBUTORSix
  • Chapter 1. Assembly and Intracellular Trafficking of GABAA Receptors1
  • I. Introduction1
  • II. Assembly of GABAA Receptors3
  • III. Surface Targeting and Intracellular Sorting of GABAA Receptors8
  • IV. GABAA Receptor-Clustering Proteins11
  • V. Endocytosis and Recycling of GABAA Receptors14
  • References23
  • Chapter 2. Subcellular Localization and Regulation of GABAA Receptors and Associated Proteins31
  • I. Introduction32
  • II. Functional Significance of GABAergic Inhibition in the Brain33
  • III. Structural Anatomy of GABAergic Synapses33
  • IV. Structure of GABAA Receptors34
  • V. Subcellular Localization of GABAA Receptor Subtypes35
  • VI. Factors Implicated in Exocytosis and Endocytosis of GABAA Receptors46
  • VII. Synaptic Anchoring of GABAC Receptors48
  • VIII. GABAA Receptor-Associated Signaling Proteins49
  • IX. Synaptic Plasticity50
  • X. Concluding Remarks54
  • References54
  • Chapter 3. D1 Dopamine Receptors65
  • I. Introduction66
  • II. Localization and Function of D1-like Receptors68
  • III. Development of Drugs for D1-like Receptors89
  • IV. Therapeutic and Functional Actions of D1 Receptor Agonists and Antagonists100
  • V. Conclusions and Future Goals116
  • References117
  • Chapter 4. Molecular Modeling of Ligand-Gated Ion Channels: Progress and Challenges141
  • I. The Challenge of Modeling Transmembrane Ion Channels141
  • II. Overview of Molecular Modeling Principles143
  • III. Experimental Data: Techniques and Results148
  • IV. Molecular Models155
  • V. Summary161
  • References162
  • Chapter 5. Alzheimer’s Disease: Its Diagnosis and Pathogenesis167
  • I. Introduction168
  • II. Diagnostic Issues169
  • III. Pathogenesis176
  • IV. Genetic Influences189
  • V. Inflammation and Anti-inflammatory Drugs194
  • VI. Estrogen Therapy197
  • VII. Vascular Pathology in AD197
  • References201
  • Chapter 6. DNA Arrays and Functional Genomics in Neurobiology219
  • I. Introduction219
  • II. DNA Array Formats and Technique221
  • III. Applications in Neurobiology232
  • IV. Caveats and Future Needs244
  • V. Conclusion248
  • References248
  • INDEX255
Book details
  • Vendor Elsevier S & T
  • SKU 9780123668486
  • ISBN-13 9780080544243
  • Author Bradley, Ronald J.
  • Category Medical
  • Subject Neuroscience

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Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.