International Review of Neurobiology
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Table of contents
- Contentsv
- Contributorsix
- Chapter 1. GABAA Receptor Structure–Function Studies: A Reexamination in Light of New Acetylcholin1
- I. Overview2
- II. Subunits, Cloning, Topology, and Assembly3
- III. Receptor Kinetics5
- IV. Channel Characteristics. Selectivity and Conductance6
- V. SCAM and Channel Structure–Function Relationships7
- VI. Overview of High-Resolution Structures of the Homologous ACh Receptor8
- VII. The Membrane-Spanning Domain Structure9
- VIII. AChBP Structure and the GABA Binding Sites24
- IX. The Interface Between the Extracellular and Membrane-Spanning Domains: How Does Transduction Wor28
- X. Conclusions30
- References31
- Chapter 2. Dopamine Mechanisms and Cocaine Reward45
- I. Introduction46
- II. Basic Pharmacology of Cocaine47
- III. Monoamine Transporters48
- IV. Nucleus Accumbens Dopamine53
- V. Prefrontal Cortex Dopamine55
- VI. Midbrain Dopamine Neurons59
- VII. Phasic and Tonic Dopamine Release60
- VIII. Dopamine Receptors61
- IX. Striatal Medium Spiny Neurons62
- X. Dopamine and Intracellular Cascades63
- XI. Neural Basis of Associative Learning65
- XII. Midbrain Dopamine Neurons and Associative Learning66
- XIII. Drug Addiction and Learning68
- XIV. Cocaine-Associative Learning69
- XV. Summary77
- References80
- Chapter 3. Proteolytic Dysfunction in Neurodegenerative Disorders95
- I. Introduction95
- II. Proteolysis in the Central Nervous System98
- III. Parkinson’s Disease101
- IV. Alzheimer’s Disease106
- V. Amyotrophic Lateral Sclerosis108
- VI. Polyglutamine Repeat Diseases109
- VII. Prion Diseases110
- VIII. Conclusion111
- References112
- Chapter 4. Neuroimaging Studies in Bipolar Children and Adolescents121
- I. Introduction121
- II. Background122
- III. Methodology123
- IV. Neuropsychological Abnormalities in Bipolar Disorder123
- V. Brain Imaging Findings in Adult Patients125
- VI. Brain Imaging Findings in Children and Adolescents133
- VII. Summary136
- References137
- Chapter 5. Chemosensory G-Protein-Coupled Receptor Signaling in the Brain147
- I. Introduction147
- II. Chemosensing G-Protein-Coupled Receptors in the Brain148
- References154
- Chapter 6. Disturbances of Emotion Regulation after Focal Brain Lesions159
- I. Definitions160
- II. The Neuroanatomy of Emotions and Feelings161
- III. Disturbances of Emotional Experience After Focal Brain Damage163
- IV. Developmental Versus Adult-Onset Brain Damage173
- V. Neural Mechanisms of Emotional Control175
- VI. Emotion, Cognition, and Social Behavior177
- VII. Conclusion187
- References189
- Chapter 7. The Use of Caenorhabditis elegans in Molecular Neuropharmacology195
- I. Ivermectin200
- II. Fluoxetine203
- III. Alcohol205
- References208
- Index213
- Contents of Recent Volumes219
Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.