Ion Channel Regulation
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Table of contents
- Contentsv
- Contributing Authorsvii
- Prologueix
- Part I: Protein Phosphorylation1
- Chapter 1. Modulation of Ion Channels by Protein Phosphorylation: How the Brain Works3
- Chapter 2. Regulation of Voltage-Sensitive Sodium and Calcium Channels by Phosphorylation23
- Chapter 3. Regulation of Ligand-Gated Ion Channels by Protein Phosphorylation49
- Chapter 4. Regulation of CFTR C1–Ion Channels by Phosphorylation and Dephosphorylation79
- Chapter 5. Ion Channels as Physiological Effectors for Growth Factor Receptor and Ras/ERK Signaling107
- Part II: Closely Associated Proteins129
- Chapter 6. Voltage-Dependent Modulation of N-Type Calcium Channels: Role of G Protein Subunits131
- Chapter 7. L-Type Calcium Channel Modulation153
- Chapter 8. G Protein Gated Potassium Channels179
- Chapter 9. The Company They Keep: Ion Channels and Their Intracellular Regulatory Partners203
- Part III: Second Messengers229
- Chapter 10. Cyclic Nucleotide Gated Channels231
- Chapter 11. Cyclic GMP and Ion Channel Regulation251
- Chapter 12. Store-Operated Calcium Channels279
- Subject Index309
Volume 33 reviews the current understanding of ion channel regulation by signal transduction pathways. Ion channels are no longer viewed simply as the voltage-gated resistors of biophysicists or the ligand-gated receptors of biochemists. They have been transformed during the past 20 years into signaling proteins that regulate every aspect of cell physiology. In addition to the voltage-gated channels, which provide the ionic currents to generate and spread neuronal activity, and the calcium ions to trigger synaptic transmission, hormonal secretion, and muscle contraction, new gene families of ion channel proteins regulate cell migration, cell cycle progression, apoptosis, and gene transcription, as well as electrical excitability. Even the genome of the lowly roundworm Caenorhabditis elegans encodes almost 100 distinct genes for potassium-selective channels alone. Most of these new channel proteins are insensitive to membrane potential, yet in humans, mutations in these genes disrupt development and increase individual susceptibility to debilitating and lethal diseases.
How do cells regulate the activity of these channels? How might we restore their normal function? In Ion Channel Regulation, many of the experts who pioneered these discoveries provide detailed summaries of our current understanding of the molecular mechanisms that control ion channel activity.
Key Features
* Reviews brain functioning at the fundamental, molecular level
* Describes key systems that control signaling between and within cells
* Explains how channels are used to stimulate growth and changes to activity of the nucleus and genome
How do cells regulate the activity of these channels? How might we restore their normal function? In Ion Channel Regulation, many of the experts who pioneered these discoveries provide detailed summaries of our current understanding of the molecular mechanisms that control ion channel activity.
Key Features
* Reviews brain functioning at the fundamental, molecular level
* Describes key systems that control signaling between and within cells
* Explains how channels are used to stimulate growth and changes to activity of the nucleus and genome