Elsevier S & T

Laboratory Animal Medicine

Fox, James G.; Anderson, Lynn C.; Loew, Franklin M.; Quimby, Fred W.; Fox, James G.

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Table of contents

Contentsv
Bennett J. Cohenix
List of Contributorsxi
Prefacexv
List of Reviewers for Chapters in This Volumexvii
Chapter 1. Laboratory Animal Medicine: Historical Perspectives1
I. Introduction1
II. Origins of Animal Experimentation2
III. Early Veterinarians in Laboratory Animal Science and Medicine3
IV. The Organizations of Laboratory Animal Science7
V. Education and Training in Laboratory Animal Medicine13
VI. Impact of Laws, Regulations, and Guidelines on Laboratory Animal Medicine14
VII. Regulation of Animal Research in the United Kingdom and Canada15
VIII. Commercial and Academic Breeding of Rodents15
IX. Conclusion15
References16
Chapter 2. Laws, Regulations, and Policies Affecting the Use of Laboratory Animals19
I. Introduction19
II. Animal Welfare20
III. Importation and Exportation of Animals and Animal Products29
IV. Hazardous Substances31
V. Recombinant DNA Research Guidelines31
References32
Chapter 3. Biology and Diseases of Mice35
I. Introduction35
II. Biology41
III. Diseases53
References113
Chapter 4. Biology and Diseases of Rats121
I. Introduction121
II. Biology123
III. Diseases134
References158
Chapter 5. Biology and Diseases of Hamsters167
I. Introduction168
II. Biology173
III. Diseases180
I. Introduction190
II. Biology190
III. Diseases191
I. Introduction193
II. Biology194
III. Diseases194
I. Introduction194
II. Biology194
III. Diseases195
I. Introduction196
II. Biology196
III. Diseases196
References197
Chapter 6. Biology and Diseases of Guinea Pigs203
I. Introduction203
II. Biology206
III. Diseases212
References241
Chapter 7. Biology and Diseases of Other Rodents247
I. Introduction248
II. Ground Squirrels or Susliks: Spermophilus250
III. Prairie Dogs: Cynomys254
IV. Pocket Gophers: Geomyidae257
V. Kangaroo Rats: Dipodomys259
VI. Wood Rats or Pack Rats: Neotoma261
VII. Grasshopper Mice: Onychomys263
VIII. White-Footed Mice or Deer Mice: Peromyscus265
IX. Rice Rats: Oryzomys267
X. Cane Mice: Zygodontomys268
XI. Cotton Rats: Sigmodon270
XII. White-Tailed Rats: Mystromys272
XIII. Gerbils and Jirds: Meriones275
XIV. Voles and Meadow Mice: Microtus279
XV. Multimammate Rats: Mastomys281
XVI. Degus or Trumpet-Tailed Rats: Octodon284
XVII. Chinchillas: Chinchilla286
References291
Chapter 8. Woodchucks as Laboratory Animals309
I. Introduction309
II. Biology312
III. Diseases319
References327
Chapter 9. Biology and Diseases of Rabbits329
I. Introduction329
II. Biology331
III. Diseases339
References358
Chapter 10. Microbiological Quality Control for Laboratory Rodents and Lagomorphs365
I. Overview365
II. Introduction366
III. Biosecurity366
IV. Microbiological (Health) Surveillance372
References387
Chapter 11. Biology and Diseases of Dogs395
I. Introduction395
II. Biology397
III. Diseases405
References454
Chapter 12. Domestic Cats as Laboratory Animals459
I. Introduction460
II. Sources of Cats462
III. Housing463
IV. Breeding Colony Management466
V. Nutrition and Feeding474
VI. Infectious Disease Exclusion and Control475
References480
Chapter 13. Biology and Diseases of Ferrets483
I. Introduction483
II. Biology485
III. Diseases490
References513
Chapter 14. Biology and Diseases of Ruminants: Sheep, Goats, and Cattle519
I. Introduction519
II. Biology525
III. Diseases537
References611
Chapter 15. Biology and Diseases of Swine615
I. Introduction615
II. Biology618
III. Diseases629
References665
Chapter 16. Nonhuman Primates675
I. Introduction676
II. Taxonomy677
III. Biology680
IV. Principles of Colony Management715
V. Medical Management724
VI. Diseases730
References777
Chapter 17. Biology and Diseases of Amphibians793
I. Introduction793
II. Biology801
III. Diseases814
References823
Chapter 18. Biology and Diseases of Reptiles827
I. Introduction827
II. Biology837
III. Diseases848
References857
Chapter 19. Biology and Management of the Zebrafish861
I. Introduction862
II. Experimental Model in Biomedical Research863
III. Health Management in the Aquatic Animal Facility866
IV. Environmental Factors Important to Health866
V. Nutrition and Feeding874
VI. Acquisition875
VII. Infectious Diseases875
References882
Chapter 20. Biology and Health of Laboratory Fishes885
I. Introduction886
II. Facility Design886
III. Management and Husbandry893
IV. Medical Protocols894
V. Zoonotic Considerations898
VI. Diseases899
References907
Chapter 21. Design and Management of Animal Facilities909
I. Introduction909
II. Facility Planning and Design910
III. Equipment931
IV. Commissioning and Validation946
V. Management946
VI. Conclusions947
References948
Chapter 22. Preanesthesia, Anesthesia, Analgesia, and Euthanasia955
I. Introduction956
II. Rodents956
III. Rabbits966
IV. Dogs973
V. Swine979
VI. Small Ruminants986
VII. Nonhuman Primates990
References997
Chapter 23. Techniques of Experimentation1005
I. Introduction1006
II. Identification Methods1006
III. Blood Collection and Intravenous Injection1008
IV. Vascular Cannulation1013
V. Intraperitoneal Injection1015
VI. Subcutaneous and Intramuscular Injection1015
VII. Digestive System1015
VIII. Urinary System Techniques1019
IX. Respiratory System Techniques1021
X. Reproductive System1023
XI. Cardiovascular Techniques1027
XII. Endocrine System Techniques1028
XIII. Orthopedic Procedures for Laboratory Animals1029
XIV. Neurosurgical Techniques1029
XV. Tumor Transplantation1032
XVI. Imaging Techniques1033
XVII. Radiotelemetry1034
References1034
Chapter 24. Control of Biohazards Associated with the Use of Experimental Animals1047
I. Introduction1047
II. Risk Assessment1048
III. Managing Facilities in Which Biohazards Are Used1048
IV. Other Considerations1053
V. Responsibility for Reviewing and Approving Protocols Involving Biohazards1056
VI. Summary1056
References1056
Chapter 25. Selected Zoonoses1059
I. Introduction1060
II. Viral Diseases1060
III. Rickettsial Diseases1074
IV. Chlamydial Infections1076
V. Bacterial Diseases1077
VI. Fungal Diseases1088
VII. Protozoal Diseases1089
VIII. Helminth Infections1093
IX. Arthropod Infestations1098
References1098
Chapter 26. Xenozoonoses: The Risk of Infection after Xenotransplantation1107
I. Introduction1107
II. Lessons from Allotransplantation1107
III. Xenotransplantation1109
References1113
Chapter 27. Genetic Monitoring1117
I. Introduction1117
II. The Need for Genetically Defined Animals1118
III. Sources and Monitoring of Genetic Variability1119
IV. Colony Management1121
V. Monitoring Methods1122
VI. Summary1126
References1127
Chapter 28. Transgenic and Knockout Mice1129
I. Introduction1129
II. Choice of Mouse Strains for Transgenic Programs1130
III. Production of Transgenic Mice: Animal Requirements1131
IV. Management of the Transgenic Mouse Colony1134
References1140
Chapter 29. Factors That May Influence Animal Research1143
I. Introduction1143
II. Intrinsic Considerations1143
III. Extrinsic Considerations1147
References1165
Chapter 30. Animal Models in Biomedical Research1185
I. What Is an Animal Model?1185
II. The Nature of Research1200
III. History of Animal Use in Biomedical Research1206
References1214
Chapter 31. Research in Laboratory Animal and Comparative Medicine1227
I. Introduction1228
II. The Research Process1229
III. Research Training1231
IV. Research Resources1234
V. Support for Research1235
VI. Summary1237
References1237
Chapter 32. Laboratory Animal Behavior1239
I. Introduction1240
II. Rodents1241
III. Rabbits1245
IV. Laboratory Dogs and Cats1246
V. Nonhuman Primates1248
VI. Farm Animals1252
References1256
Index1265

Book details

Vendor Elsevier S & T
SKU 9780122639517
ISBN-13 9780080535333
Author Fox, James G.; Anderson, Lynn C.; Loew, Franklin M.; Quimby, Fred W.; Fox, James G.
Edition 2nd
Category Medical
Subject Research

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A volume in the American College of Laboratory Animal Medicine series, this second edition has over 40% new material, including the addition of six new topics and many others that are completely rewritten. The book comprehensively covers the biological and disease aspects of laboratory animal medicine while examining other aspects such as the biohazards associated with the use of animal experimentation and factors complicating the bioethics of animal research.

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