Macromolecular Crystallography, Part C

Carter, Jr., Charles W.

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Table of contents
  • Table of Contentsv
  • Contributor to Volume 368vii
  • Prefaceix
  • Volumes in Seriesxi
  • Section I: Reminiscences on Methods1
  • Chapter 1. Transformations in Structural Biology: Personal View3
  • Chapter 2. Origins11
  • Chapter 3. Personal X-ray Reflections21
  • Section II: Crystals43
  • Chapter 4. Robotics for Automated Crystal Formation and Analysis45
  • Chapter 5. Use of Limited Proteolysis to Identify Protein Domains Suitable for Structural Analysis77
  • Chapter 6. Solvent Entropy Effects in the Formation of Protein Solid Phases84
  • Chapter 7. Controlling Biomolecular Crystallization by Understanding the Distinct Effects of PEGs an105
  • Chapter 8. Counter-diffusion Methods for Macromolecular Crystallization130
  • Chapter 9. Growth Sectors and Crystal Quality154
  • Chapter 10. Molecular Mechanisms of Defect Formation170
  • Chapter 11. Cryocooling of Macromolecular Crystals: Optimization Methods188
  • Chapter 12. The Well-Tempered Protein Crystal:Annealing Macromolecular Crystals217
  • Section III: Data237
  • Chapter 13. What Can I Have As a Source of X-Ray Synchrotron Radiation? A Primer for Potential Users239
  • Chapter 14. Protein Crystal Structure Analysis from High- Resolution X-Ray Powder-Diffraction Data254
  • Chapter 15. Macromolecular Crystal Quality268
  • Chapter 16. Protein Structures at Atomic Resolution288
  • Author Index339
  • Subject Index363
  • Color Plates SectionColor Plete-1
Book details
  • Vendor Elsevier S & T
  • SKU 9780121822712
  • ISBN-13 9780080497099
  • Author Carter, Jr., Charles W.
  • Category Science
  • Subject Biochemistry

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Accurate molecular structures are vital for rational drug design and for structure-based functional studies directed toward the development of effective therapeutic agents and drugs. Crystallography can reliably predict structure, both in terms of folding and atomic details of bonding.

* Methodological methods in crystals
* Methodological methods data analysis