Matrix Metalloproteinases
Regular price
57.500 KD
inc. VAT
Couldn't load pickup availability
Table of contents
- Cover
- Contentsv
- Contributorsix
- Prefacexi
- Chapter 1. The Matrix Metalloproteinase Family1
- I. Introduction1
- II. The Position of MMPs within the Class of Metalloproteases3
- III . The Matrixin Subfamily4
- IV. The Domain Structure of the Matrixins7
- V. The Biological Role of the Matrixins9
- VI. What the Future Might Hold12
- References13
- Chapter 2. Interstitial Collagenases15
- I. Introduction15
- II. Matrix Metalloproteinase - 1: The Original Interstitial Collagenase16
- III ." Nontraditional " Interstitial Collagenases35
- IV. Summary and Future Perspectives37
- References38
- Chapter 3. Stromelysins 1 and 243
- I. Introduction43
- II. Structure and Substrate Specificity44
- III . Activation Mechanisms51
- IV. Inhibitors54
- V. Regulation of Gene Expression56
- VI. Biological and Pathological Roles60
- VII. Conclusions and Future Prospects67
- References68
- Chapter 4. 72-kDa Gelatinase (Gelatinase A): Structure, Activation, Regulation, and Substrate Specif85
- I. Introduction85
- II. Matrix Metalloproteinase Family86
- III. Multilevel Regulation of Gelatinase A88
- IV. Substrate Specificity97
- V. Role of Gelatinase A in Cellular Processes99
- VI. Role of Gelatinase A in Platelet Aggregation105
- VII. Perspectives105
- References106
- Chapter 5. Gelatinase B: Structure, Regulation, and Function115
- I. Introduction115
- II. Gene Structure116
- III. Protein Structure and Activation119
- IV. Substrates and Inhibitors122
- V. Regulation of Expression124
- VI. Function128
- VII. Conclusion and Future Directions136
- References137
- Chapter 6. Matrilysin149
- I. Introduction149
- II. Amino Acid Sequence and Gene Organization149
- III. Regulation of Expression152
- IV. Protein Structure and Proteolytic Activities157
- V. Expression in Cancer and Other Diseases164
- VI. Role in Normal Tissue Remodeling and Homeostasis169
- VII. Summary and Concluding Remarks174
- References177
- Chapter 7. Macrophage Elastase (MMP-12)185
- I. Introduction185
- II. The Gene for Macrophage Elastase and Its Expression187
- III. Activation and Processing187
- IV. Protein Preparation188
- V. Catalytic Features188
- VI. Inhibition190
- VII. Biological Aspects190
- VIII. Summary195
- References196
- Chapter 8. Membrane-Type Matrix Metalloproteinases and Cell Surface- Associated Activation Cascades199
- I. Introduction199
- II. Potential Activation Routes for Matrix Metalloproteinases200
- III. Structure of Membrane-Type Matrix Metalloproteinases202
- IV. Cellular Sources of MT-MMPs and Regulation of Expression204
- V. Activation of MT-MMPs206
- VI. Activation of Progelatinase A by MT1-MMP and MT2-MMP207
- VII. Activation of Procollagenase-3 by MT1-MMP210
- VIII. Substrate Specificity of MT-MMPs211
- IX. Summary212
- References214
- Chapter 9. Substrate Specificity and Mechanisms of Substrate Recognition of the Matrix Metalloprotei219
- I. Introduction219
- II. Peptide Sequence Specificity221
- III. Protein Substrate Specificity228
- IV. Mechanisms of Substrate Recognition233
- References238
- Chapter 10. Synthetic Inhibitors of Matrix Metalloproteinases243
- I. Introduction243
- II. Design of Synthetic Inhibitors244
- III. Role of Matrix Metalloproteinases in Cancer247
- IV. Effects of Matrix Metalloproteinase Inhibitors in Cancer Models249
- V. Clinical Trials253
- VI. Proteinase Inhibition as Therapy255
- References256
- Chapter 11. Matrix Metalloproteinases in Tissue Repair263
- I. Introduction: Studying the Regulation and Function of Metalloproteinases263
- II. Collagenase-1 in Tissue Repair266
- III. The Role of Collagenase-1 in Reepithelialization277
- IV. Expression of Other Metalloproteinases in Wound Repair283
- V. Regulation of Collagenase-1 in Wound Fibroblasts286
- VI. Metalloproteinases in Chronic Wounds288
- VII. Summary289
- References290
- Chapter 12. Regulation of Matrix Metalloproteinase Gene Expression299
- I. Introduction300
- II. Collagenase302
- III . Stromelysins321
- IV. Gelatinase B327
- V. Gelatinase A334
- VI. Summary and Future Perspectives338
- References339
- Index357
The chapters in this book thoroughly cover the structure, regulation, and function of matrix metalloproteinases, and provide information on the latest strategies to inhibit enzyme activity. This work will be an indispensable reference tool for investigators with an interest in extracellular matrix biology, matrix turnover, enzymology and biochemistry of proteinases, developmental biology, pathology, and therapeutic interventions.
Key Features
* Provides state-of-the-art information on a field with broad implications to many areas of biology
* Includes detailed coverage of the structure and regulation of all major matrix metalloproteinases
* Chapters focus on a timely and expanding field
* Topics have direct relevance to understanding human disease pathology of cancer, arthritis, and vascular disease
* Discusses latest strategies used in the development of new therapeutics to inhibit metalloproteinase activity
Key Features
* Provides state-of-the-art information on a field with broad implications to many areas of biology
* Includes detailed coverage of the structure and regulation of all major matrix metalloproteinases
* Chapters focus on a timely and expanding field
* Topics have direct relevance to understanding human disease pathology of cancer, arthritis, and vascular disease
* Discusses latest strategies used in the development of new therapeutics to inhibit metalloproteinase activity