Elsevier S & T

Mechanisms of Memory

Sweatt, J. David

In stock
No reviews
38.250 KD inc. VAT
License
Table of contents
  • Cover
  • Contentsvii
  • Forewordxi
  • Prefacexiii
  • Acknowledgmentsxvii
  • Chapter 1. Introduction„The Basics of Psychological Learning and Memory Theory3
  • I. Introduction3
  • II. Unconscious Learning12
  • III. Conscious Learning„Subject to Conscious and Unconscious Recall23
  • IV. Final Note„Will Molecular Studies Change the Way We Think about Learning Behavior?26
  • References27
  • Chapter 2. Rodent Behavioral Learning and Memory Models29
  • I. Introduction29
  • II. Behavioral Assessments in Rodents30
  • III. Modern Experimental Uses of Rodent Behavioral Models44
  • IV. Control Experiments53
  • V. Summary58
  • References58
  • Chapter 3. The Hippocampus Serves a Role in Multimodal Information Processing, and Memory Consolidat61
  • I. Introduction61
  • II. Studying the Hippocampus62
  • III. Hippocampal Function in Cognition65
  • IV. Summary87
  • References87
  • Chapter 4. Long-Term Potentiation as a Physiological Phenomenon91
  • I. Synapses in the Hippocampus„The Hippocampal Circuit93
  • II. A Breakthrough Discovery„LTP in the Hippocampus94
  • III. NMDA Receptor-Dependence of LTP102
  • IV. NMDA Receptor-Independent LTP110
  • V. A Role for Calcium Influx in NMDA Receptor-Dependent LTP112
  • VI. Summary114
  • References114
  • Chapter 5. Complexities of Long-Term Potentiation117
  • I. Introduction117
  • II. Presynaptic Versus Postsynaptic Mechanisms118
  • III. LTP Can Include an Increased AP Firing Component127
  • IV. Temporal Integration in LTP Induction130
  • V. LTP Can Be Divided into Phases131
  • VI. Spine Anatomy and Biochemical Compartmentalization142
  • VII. Summary144
  • References144
  • Chapter 6. The Biochemistry of LTP Induction147
  • I. Introduction148
  • II. LTP Induction Component 1„ Mechanisms Upstream of the NMDA Receptor That Directly Regulate NMD150
  • III. LTP Induction Component 2„ Mechanisms Upstream of the NMDA Receptor That Control Membrane Dep154
  • IV. LTP Induction Component 3„The Components of the Synaptic Infrastructure That Are Necessary for163
  • V. LTP Induction Component 4„ Feed-Forward and Feedback Mechanisms That Regulate the Level of Calc174
  • VI. LTP Induction Component 5„Extrinsic Signals That Regulate the Response to the Calcium Influx177
  • VII. LTP Induction Component 6„The Mechanisms for the Generation of the Actual Persisting Biochemi181
  • VIII. Summary„Models for Biochemical Information Processing in LTP Induction182
  • References184
  • Chapter 7. Biochemical Mechanisms for Short-Term Information Storage at the Cellular Level189
  • Chapter Overview189
  • I. Targets of the Calcium Trigger192
  • II. Targets of the Persisting Signals212
  • III. Dendritic Protein Synthesis221
  • IV. Chapter Summary226
  • References226
  • Chapter 8. Biochemical Mechanisms for Long-Term Information Storage at the Cellular Level233
  • Introduction233
  • I. The Case for Altered Gene Expression in L-LTP235
  • II. Signaling Mechanisms240
  • III. Summary„Altered Genes and Altered Circuits257
  • References258
  • Chapter 9. LTP Does Not Equal Memory263
  • I. LTP Does Not Equal Memory264
  • II. Roles for LTP285
  • III. Summary298
  • References298
  • Chapter 10. Inherited Disorders of Human Memory„Mental Retardation Syndromes307
  • I. Neurofibromatosis, Coffin-Lowry Syndrome, and the ras/ERK Cascade308
  • II. Angelman Syndrome316
  • III. Fragile X Syndromes325
  • IV. Summary332
  • References333
  • Chapter 11. Aging-Related Memory Disorders„ Alzheimers Disease337
  • I. Aging-Related Memory Decline338
  • II. What Is AD?339
  • III. Genes„Familial and Late-Onset AD352
  • IV. Apolipoprotein E in the Nervous System355
  • V. Mouse models for AD355
  • VI. Summary360
  • References360
  • Chapter 12. The Chemistry of Perpetual Memory367
  • I. Short-, Long-, and Ultralong-Term Forms of Learning372
  • II. Use of Invertebrate Preparations to Study Simple Forms of Learning373
  • III. Short-Term Facilitation in Aplysia is Mediated by Changes in the Levels of Intracellular Second377
  • IV. Intermediate-Term Facilitation in Aplysia Involves Altered Gene Expression and Persistent Protei378
  • V. Long-Term Synaptic Facilitation in Aplysia Involves Changes in Gene Expression and Resulting Anat379
  • VI. Three Attributes of Chemical Reactions Mediating Memory384
  • VII. Summary: A General Chemical Model for Memory388
  • References389
  • Index391
Book details
  • Vendor Elsevier S & T
  • SKU 9780126789577
  • ISBN-13 9780080521961
  • Author Sweatt, J. David
  • Category Medical
  • Subject Neuroscience

Do you have questions about this book?

Ask an expert!

Description eBook delivery & access Reviews
This book stands as the first unified overview of the cellular and molecular mechanisms underlying higher-order learning and memory. It integrates modern discoveries concerning learning and memory disorders such as mental retardation syndromes and Alzheimer's Disease, while also emphasizing the results gained from the cutting-edge research methodologies of genetic engineering, complex behavioral characterization, proteomics, and molecular biology. This book provides a foundation of experimental design that will be useful to all students pursuing an interest in laboratory research. This book is an enlightening and invaluable resource for anyone concerned with memory mechanisms.

* Presents a unified view of memory mechanisms from behavior to genes and drawing examples from many different brain regions, types of learning, and various animal model systems
* Includes numerous practical examples for the new investigator on how to implement research program in the area of learning and memory
* Provides a balanced treatment of the strengths and weaknesses in modern experimental design