Elsevier S & T

Membrane Lipid Signaling in Aging and Age-Related Disease

Mattson, M.P.

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Table of contents
  • Cover
  • TABLE OF CONTENTSv
  • Prefacevii
  • Chapter 1. Overview: Spatial Control of Signal Transduction by Caveolae and Lipid Rafts1
  • Chapter 2. Overview: Membrane Lipid Peroxidation11
  • Chapter 3. Regulation of Invertebrate Longevity by Inositol Phosphate Signaling27
  • Chapter 4. Ceramide-Driven Stress Signals in Cancer and Aging47
  • Chapter 5. Sphingolipid Metabolism and Signaling in Atherosclerosis71
  • Chapter 6. Sphingomyelin and Ceramide in Brain Aging, Neuronal Plasticity and Neurodegenerative Diso97
  • Chapter 7. The Eicosanoid Pathway and Brain Aging117
  • Chapter 8. Cellular Cholesterol, Membrane Signaling, and Disease137
  • Chapter 9. Cholesterol, β-amyloid, and Alzheimer’s Disease163
  • Chapter 10. Phospholipase A2 in the Pathogenesis of Cardiovascular Disease177
  • Chapter 11. Retinal Docosahexaenoic Acid, Age-Related Diseases, and Glaucoma205
  • List of Contributors223
Book details
  • Vendor Elsevier S & T
  • SKU 9780444512970
  • ISBN-13 9780080522500
  • Author Mattson, M.P.
  • Category Social Science
  • Subject Gerontology

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The lipids of cellular membranes not only serve roles in controlling the structure and fluidity of the membrane, but are increasingly recognized for their roles as signalling molecules and modifiers of membrane protein function. Recent studies described in this volume reveal striking changes in membrane lipids during aging and in age-related diseases such as cancer, cardiovascular disease and neurodegenerative disorders. Lipids including inositol phospholipids, cholesterol, sphingolipids and ceramides play important roles in signalling cellular responses to stress and specific stimuli such as growth factors, cytokines and neurotransmitters. One or more of these lipid mediators has been linked to the pathogenesis of age-related diseases.



This book provides a comprehensive review of specific membrane lipid mediators and their roles in aging and age-related disease.