Membrane Proteins
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Table of contents
- CONTENTSv
- PREFACExi
- Chapter 1. Membrane Protein Assembly in Vivo1
- I. Introduction1
- II. Overview of Membrane Protein Assembly Pathways in Prokaryotic and Eukaryotic Cells2
- III. Membrane Protein Assembly in the ER3
- IV. Membrane Protein Assembly in Escherichia coli9
- V. Membrane Protein Assembly in Mitochondria10
- VI. Membrane Protein Assembly in Chloroplasts12
- VII. Membrane Protein Assembly in Peroxisomes12
- VIII. Conclusions12
- References13
- Chapter 2. Construction of Helix-Bundle Membrane Proteins19
- I. Introduction19
- II. Transmembrane Helix Structure20
- III. Thermodynamic Studies24
- IV. The Contribution of Loops versus Transmembrane Helices28
- V. Forces That Stabilize Transmembrane Helix Interactions29
- VI. Conclusions42
- References43
- Chapter 3. Transmembrane β-Barrel Proteins47
- I. Introduction47
- II. Structures49
- III. Construction Principles55
- IV. Functions59
- V. Folding and Stability61
- VI. Channel Engineering63
- VII. Conclusions65
- References66
- Chapter 4. Length, Time, and Energy Scales of Photosystems71
- I. Introduction71
- II. Overview of Length Scales in Bioenergetic Membranes72
- III. Managing Lengths in Natural Redox Protein Design75
- IV. Managing Length and Size in Natural Light-Harvesting Design78
- V. Managing Distance in Electron Transfer82
- VI. Managing Proton Reactions in Photosynthesis93
- VII. Managing Diffusion in Photosynthesis103
- VIII. Summary105
- References106
- Chapter 5. Structural Clues to the Mechanism of Ion Pumping in Bacteriorhodopsin111
- I. Introduction111
- II. The Ground, or Resting, State115
- III. Early Photocycle Intermediates (K and L)118
- IV. M Intermediates121
- V. Large-Scale Conformational Changes in the M, N, and O Intermediates123
- VI. Protonation Pathways in the M to N and the N to O Reactions125
- References127
- Chapter 6. The Structure of Wolinella succinogenes Quinol: Fumarate Reductase and Its Relevance to131
- I. Introduction131
- II. Overall Description of the Structure134
- III. The Hydrophilic Subunits134
- IV. Subunit C, the Integral Membrane Diheme Cytochrome b137
- V. General Comparison of Membrane-Integral Diheme Cytochrome b Proteins139
- VI. Relative Orientation of Soluble and Membrane-Embedded QFR Subunits141
- VII. The Site of Menaquinol Oxidation/Menaquinone Reduction141
- VIII. Electron and Proton Transfer and the Wolinella succinogenes Paradox142
- IX. The E-Pathway HypothesisŽ of Coupled Transmembrane Electron and Proton Transfer145
- X. Concluding Remarks146
- References147
- Chapter 7. Structure and Function of Quinone Binding Membrane Proteins151
- I. Introduction151
- II. Structure of Cytochrome bc1 Complex from Bovine Heart Mitochondria153
- III. The Structure of Cytochrome bo3 Ubiquinol Oxidase from Escherichia coli165
- IV. Conclusion174
- References174
- Chapter 8. Prokaryotic Mechanosensitive Channels177
- I. Introduction177
- II. MscL: Structure and Mechanism185
- III. MscS and Other Prokaryotic Mechanosensitive Channels200
- IV. What Makes a Mechanosensitive Channel Mechanosensitive?204
- V. Concluding Remarks205
- References206
- Chapter 9. The Voltage Sensor and the Gate in Ion Channels211
- I. Introduction211
- II. The Voltage Sensor212
- III. The Channel Gate228
- References238
- Chapter 10. Rhodopsin Structure, Dynamics, and Activation: A Perspective from Crystallography, Site-243
- I. Introduction to Rhodopsin and Visual Signal Transduction243
- II. The Rhodopsin Crystal Structure: The Inactive State249
- III. Structure and Dynamics of Rhodopsin in Solutions of Dodecyl Maltoside: The Cytoplasmic Surface253
- IV. Location of the Membrane–Aqueous Interface and the Structure of the Disk Membrane274
- V. Photoactivated Conformational Changes: The Rhodopsin Activation Switch277
- VI. Summary: The Mechanism of Rhodopsin Activation and Future Directions285
- References286
- Chapter 11. The Glycerol Facilitator GlpF, Its Aquaporin Family of Channels, and Their Selectivity291
- I. An Ancient and Long Recognized Channel291
- II. Three-Dimensional Structure of GlpF with Glycerol in Transit295
- III. The Basis for Selectivity through the Channel299
- IV. Roles of Conserved Residues: Functional and Structural301
- V. Stereoselective Preferences of GlpF among Linear Alditols303
- VI. Simulations and Rates of Glycerol Passing through the Channel304
- VII. Simulation and Rates of Water Passage through the GlpF (an AQP) Channel305
- VIII. Insulation against Proton Conduction in AQPs307
- IX. Quaternary Structure of GlpF (and AQPs)307
- X. The Ion Channel in AQP6; a Possible Pore on the Fourfold Axis of AQPs?309
- XI. GlpF Channel Selectivity for Antimonite309
- XII. Selectivity against Passing Ions or an Electrochemical Gradient309
- XIII. The Various Contributions to Rejection of Proton Conductance310
- XIV. Selectivity for Glycerol versus Water311
- XV. Regulated Ion Channels Formed by Members of the AQP Family312
- References313
- AUTHOR INDEX317
- SUBJECT INDEX337
This volume covers 2 major topics: Foundations and Membrane Protein Structures.
Key Features
* Foundations
* Bioenergetic Processes
* Channels and Receptors
Key Features
* Foundations
* Bioenergetic Processes
* Channels and Receptors