Molecular Genetics, Gene Transfer, and Therapy
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Table of contents
- Contentsv
- Contributorsix
- Prefacexi
- Chapter I. From Molecular Genetics to Diagnosis and Gene Therapy1
- I. Introduction to Molecular Genetics2
- II. Gene Manipulation7
- III. Studies of Metabolic and Gene Regulation18
- IV. Diagnosis of Genetic Disease21
- V. Therapy of Genetic Diseases33
- VI. Use of Recombinant DNA Methods to Improve Domestic Animals35
- VII. Legal and Ethical Aspects of Patenting Biotechnology39
- References41
- Chapter II. Genes Involved in Oncogenesis51
- I. Introduction52
- II. Detection of Genes Involved in Oncogenesis53
- III. Mapping and Cloning Genes Involved in Oncogenesis66
- IV. Animal Model Systems Used to Study Gene Function69
- V. Identity and Function of Genes Involved in Oncogenesis73
- VI. Applications of Oncogene Research86
- VII. Conclusion93
- References93
- Chapter III. Diagnostic Molecular Genetics103
- I. Introduction103
- II. Methods104
- III. Linkage Analysis107
- IV. Single-Gene Disorders110
- V. Future Directions114
- Acknowledgments115
- References115
- Chapter IV. Gene Therapy for the Hemophilias119
- I. Introduction119
- II. Advantages of Gene Therapy as a Treatment for Hemophilia120
- III. Advantages of Hemophilia as a Model for Gene Therapy121
- IV. Choice of Vector122
- V. Factor IX126
- VI. Factor VIII129
- VII. Summary130
- References131
- Chapter V. Genes Controlling Retroviral Virulence135
- I. Introduction135
- II. Retrovirus Structure and Replication136
- III. Additional Retrovirus Genes140
- IV. Feline Acquired Immunodeficiency Syndrome144
- V. Murine AIDS145
- VI. Simian AIDS145
- VII. Murine Leukemia Virus146
- VIII. Endogenous Retroviruses148
- IX. Lentiviruses149
- References152
- Chapter VI. Mapping Animal Genomes157
- I. Introduction157
- II. Why Map Farm Animal Genomes158
- III. Methods for Animal Genome Mapping161
- IV. Current Status of Animal Genome Maps168
- V. Future Directions183
- References184
- Chapter VII. The Canine Genome191
- I. Introduction191
- II. Applications of a Canine Genetic Map193
- III. Organization of the Canine Genome196
- IV. Development of a Canine Genetic Map198
- V. Targeted Cloning of Canine Genes208
- VI. Considerations and Conclusions210
- References212
- Index217
Animal science is being transformed by advances in molecular genetics. This book covers this exciting transformation. Both the diagnosis and treatment of disease are discussed in seven chapters by a team of leading international authorities. From oncogenesis and hemophilia to retroviral virulence and genome mapping, this volume yields an understanding of fundamental mechanisms of action and insightful means of diagnosis and treatment. Practicing veterinarians and researchers in animal science will find this book useful.