Elsevier S & T

Multiple Sclerosis As A Neuronal Disease

Waxman, Stephen

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Table of contents
  • Cover
  • Contentsv
  • Prefacevii
  • Contributorsix
  • Part I: Structure, Molecular Organization, and Function of Myelinated Axons1
  • Chapter 1. The Structure of Myelinated Axons in the CNS1
  • Chapter 2. Dialogues: Communication Between Axons and Myelinating Glia29
  • Chapter 3. Molecular Specializations at the Glia-Axon Interface45
  • Chapter 4. Potassium Channel Organization of Myelinated and Demyelinated Axons57
  • Chapter 5. The Roles of Potassium and Calcium Channels in Physiology and Pathophysiology of Axons69
  • Part II: Neuronal Concomitants of Demyelination85
  • Chapter 6. The Conduction Properties of Demyelinated and Remyelinated Axons85
  • Chapter 7. Altered Distributions and Functions of Multiple Sodium Channel Subtypes in Multiple Scler101
  • Chapter 8. Na+ Channel Reorganization in Demyelinated Axons119
  • Chapter 9. Ion Currents and Axonal Oscillators: A Possible Biophysical Basis for Positive Signs and131
  • Chapter 10. Clinical Pharmacology of Abnormal Potassium Channel Organization in Demyelinated Axons145
  • Part III: Multiple Sclerosis as a Neurodegenerative Disease153
  • Chapter 11. Pathology of Neurons in Multiple Sclerosis153
  • Chapter 12. Axonal Degeneration in Multiple Sclerosis: The Histopathological Evidence165
  • Chapter 13. Natural History of Multiple Sclerosis: When Do Axons Degenerate?185
  • Part IV: Measurement of Neuronal Changes in the Clinical Domain201
  • Chapter 14. Brain Atrophy as a Measure of Neurodegeneration and Neuroprotection201
  • Chapter 15. MRI–Clinical Correlations in Multiple Sclerosis: Implications for Our Understanding of215
  • Chapter 16. Electrophysiological Correlates of Relapse, Remission, Persistent Sensorimotor Deficit,227
  • Part V: Cellular and Molecular Mechanisms of Axonal Degeneration in Multiple Sclerosis241
  • Chapter 17. Inflammation and Axon Degeneration241
  • Chapter 18. Nitric Oxide and Axonal Pathophysiology255
  • Chapter 19. Molecular Mechanisms of Calcium Influx in Axonal Degeneration275
  • Chapter 20. Axonal Damage and Neuron Death in Multiple Sclerosis and Experimental Autoimmune Encepha293
  • Chapter 21. Mutations of Myelination-Associated Genes That Affect Axonal Integrity305
  • Part VI: Other Aspects of Neuronal Injury in Multiple Sclerosis317
  • Chapter 22. Neuronal Blocking Factors in Demyelinating Diseases317
  • Chapter 23. Evidence for Neuronal Apoptosis in Demyelinating CNS Diseases327
  • Part VII: Lessons from the Peripheral Nervous System341
  • Chapter 24. Mechanisms Underlying Wallerian Degeneration341
  • Chapter 25. AMAN: What It Teaches Us about Mechanisms Underlying Axonal Injury355
  • Part VIII: Prognosis, Reparative Mechanisms, and Therapeutic Approaches373
  • Chapter 26. Axonal Degeneration as a Predictor of Outcome in Neurological Disorders373
  • Chapter 27. Remyelination as Neuroprotection389
  • Chapter 28. Transplantation of Peripheral-Myelin-Forming Cells to Repair Demyelinated Axons421
  • Chapter 29. Blocking the Axonal Injury Cascade: Neuroprotection in Multiple Sclerosis and Its Models435
  • Chapter 30. Functional Brain Reorganization and Recovery after Injury to White Matter451
  • Index467
Book details
  • Vendor Elsevier S & T
  • SKU 9780127387611
  • ISBN-13 9780080489414
  • Author Waxman, Stephen
  • Category Medical
  • Subject Neuroscience

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This book examines the role of neurons in multiple sclerosis (MS) and the changes that occur in neurons as a result of MS. It places MS in a new and important perspective that not only explains the basis for symptom production, remission, and progress in MS, but also promises to open up new therapeutic possibilities.

* Brings together the latest information from clinical, pathological, imaging, molecular, and pharmacological realms to explore the neurobiology of Multiple Sclerosis
* Places MS in a new and important perspective that promises to open up new therapeutic avenues
* Superbly illustrated and referenced