Elsevier S & T

Neurobiology of the Immune System

Clow, Angela; Hucklebridge, Frank

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Table of contents

Copyright Pageiv
Contentsv
Contributorsxi
Prefacexiii
Chapter 1. Neuroimmune Relationships in Perspective1
I. Introduction1
II. Innate and Acquired Immunity2
III. The Neuroendocrine System and the Balance of the Immune System9
IV. Conclusions14
Chapter 2. Sympathetic Nervous System Interaction with the Immune System17
I. Introduction17
II. Anatomy and Physiology18
III. Adrenergic Receptor Expression on Immune Cells21
IV. Effect of β2AR Stimulation on CD4+ T Lymphocytes25
V. Effect of β2AR Stimulation on B Lymphocytes28
VI. Conclusion31
References32
Chapter 3. Mechanisms by Which Cytokines Signal the Brain43
I. Introduction43
II. Interleukin-1 (IL-1)49
III. Conclusions58
References59
Chapter 4. Neuropeptides: Modulators of Immune Responses in Health and Disease67
I. Introduction67
II. CRH and Related Peptides68
III. Pro-opiomelanocortin (POMC) Peptides70
IV. Opioid Peptides Other Than β-Endorphin75
V. Trophic Peptides79
VI. Other Immunoneuropeptides80
VII. Quantitative Analysis of Immunoneuropeptides by MACS81
VIII. Conclusions82
References84
Chapter 5. Brain–immune Interactions in Sleep93
I. Sleep93
II. Microbial Products and Cytokines: A Brief Overview98
III. Effects of Microbial Products and Cytokines on Sleep102
IV. Effect of Sleep–Wake Activity on Cytokines and the Immune System111
V. Summary121
References123
Chapter 6. Neuroendocrinology of Autoimmunity133
I. Introduction133
II. The Hypothalamic-Pituitary-Adrenal (HPA) Axis134
III. The HPA Axis in Autoimmune Disease138
IV. Neurotransmitters in Disease151
V. Summary154
References155
Chapter 7. Systemic Stress-Induced Th2 Shift and Its Clinical Implications163
I. Introduction163
II. Th1/Th2 Paradigm: Role of Type 1 and Type 2 Cytokines164
III. Stress Hormones and Th1/Th2 Balance166
IV. Clinical Implications171
V. Conclusions179
References180
Chapter 8. Neural Control of Salivary S-IgA Secretion187
I. Introduction187
II. Nerve-Mediated Increases in Salivary Secretion of S-IgA189
III. Autonomimetic Stimulation of pIgR-Mediated IgA Transcytosis192
IV. Studies of Reflex IgA Secretion199
V. Long-Term Influences of Nerves on S-IgA Secretion204
VI. Effects of Nerves on Plasma Cell Production of IgA206
VII. Conclusion208
References208
Chapter 9. Stress and Secretory Immunity213
I. Introduction214
II. Saliva as a Model for Mucosal Secretory Defense215
III. An Outline of Secretory Immunity216
IV. The Neurobiological Basis for Stress-Induced Changes in Salivary Secretory Immunity218
V. Stress and Secretory IgA223
VI. Stress and Innate Secretory Immunity240
VII. Stress and Microbial Colonization Processes242
VIII. Future Perspectives243
References245
Chapter 10. Cytokines and Depression255
I. Introduction255
II. Depression and Immune System Dysregulation256
III. Neuroendocrine Dysregulation260
IV. Relationship between Immune and Neuroendocrine System Changes262
V. Effect of Cytokines on Mood263
VI. Role of Brain Monoamines264
VII. Conclusions267
References268
Chapter 11. Immunity and Schizophrenia: Autoimmunity, Cytokines, and Immune Responses275
I. Background275
II. Autoimmune Diseases and Schizophrenia277
III. T and B Lymphocytes in Schizophrenia281
IV. HLA Antigens in Schizophrenia288
V. HPA Axis in Schizophrenia289
VI. Effects of Antipsychotic Medication290
VII. Treatment of Schizophrenia with Immunosuppressants291
VIII. Vaccine Response291
IX. Th1/Th2 Imbalance in Schizophrenia292
X. Summary294
References294
Chapter 12. Cerebral Lateralization and the Immune System303
I. Introduction303
II. Opposite Effects of Left- and Right-Cortical Ablations on Immunity305
III. Association between Behavioral Lateralization and Immune Reactivity309
IV. General Conclusion and Perspectives317
References318
Chapter 13. Behavioral Conditioning of the Immune System325
I. Introduction325
II. Conditioned Immunosuppression Using Cyclosporin A332
III. Conditioned Immunopotentiation335
IV. Antigen as the Unconditioned Stimulus338
V. Human Studies342
VI. Conclusions347
References348
Chapter 14. Psychological and Neuroendocrine Correlates of Disease Progression353
I. Introduction353
II. Psychological Correlates Associated with Disease Progression355
III. Intervention Studies363
IV. Neuroendocrine and Immunological Correlates That Underpin Disease Progression364
V. Neuroimmune Alterations Associated with Psychological Interventions369
VI. Other Explanatory Mechanisms in Disease Progression372
References373
Chapter 15. The Role of Psychological Intervention in Modulating Aspects of Immune Function in Relat383
I. Introduction383
II. Relaxation Training384
III. Guided Imagery of the Immune System388
IV. Hypnosis and Immunity403
V. Research Directions406
References412
Index419
Contents of Recent Volumes433

Book details

Vendor Elsevier S & T
SKU 9780123668530
ISBN-13 9780080491608
Author Clow, Angela; Hucklebridge, Frank
Category Medical
Subject Neuroscience

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Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.

Key Features
*Provides solid scientific basis to our understanding of the associations between the brain and the immune system the importance of these connections
* Presents coherent development from cellular and molecular neuroimmune communication to social and health considerations, including psychological intervention
* Addresses the theory that there is a neurobiology of the immune system

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